Rodent Species Distribution and Hantavirus Seroprevalence in Residential and Forested areas of Sarawak, Malaysia

Hamdan, Nur Elfieyra Syazana; Ng, Y.L; Lee, Wei Bin; Tan, Cheng Siang; Khan, Faisal Ali Anwarali; Chong, Yee Ling

doi:10.21315/tlsr2017.28.1.11

Cited by 9 publications

(7 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our model predicted low zoonotic capacity for Mus musculus (0.11), corresponding with in vivo experiments suggesting this species is not susceptible to infection by the initial human variant of SARS-CoV-2 [19], although notably, more recent experiments have confirmed the susceptibility of M. musculus to two newer human-derived variants [20]. Also in the top 10% were two rodent species considered to be human commensals whose geographic ranges are expanding due to human activities: Rattus argentiventer (0.84) and R. tiomanicus (0.79) (Supplementary File 1) [119][120][121]. Additional common rodent species with relatively high probabilities of zoonotic capacity include domesticated guinea pigs (Cavia porcellus), gerbils (Gerbillus gerbillus, Meriones tristrami), and several common mouse species (Apodemus peninsulae, A. flavicollis, and A. sylvaticus), all of which are known reservoirs for other zoonotic diseases [122][123][124].…”

Section: Discussionmentioning

confidence: 99%

Predicting the zoonotic capacity of mammals to transmit SARS-CoV-2

Fischhoff

Castellanos

Rodrigues

et al. 2021

Preprint

View full text Add to dashboard Cite

Spillback transmission from humans to animals, and secondary spillover from animal hosts back into humans, have now been documented for SARS-CoV-2. In addition to threatening animal health, virus variants arising from novel animal hosts have the potential to undermine global COVID-19 mitigation efforts. Numerous studies have therefore investigated the zoonotic capacity of various animal species for SARS-CoV-2, including predicting both species' susceptibility to infection and their capacities for onward transmission. A major bottleneck to these studies is the limited number of sequences for ACE2, a key cellular receptor in chordates that is required for viral cell entry. Here, we combined protein structure modeling with machine learning of species' traits to predict zoonotic capacity of SARS-CoV-2 across 5,400 mammals. High accuracy model predictions were strongly corroborated by in vivo empirical studies, and identify numerous mammal species across global COVID-19 hotspots that should be prioritized for surveillance and experimental validation.

show abstract

Section: Discussionmentioning

confidence: 99%

Predicting the zoonotic capacity of mammals to transmit SARS-CoV-2

Fischhoff

Castellanos

Rodrigues

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Experimental infection, viral shedding and sustained intraspecific transmission of SARS-CoV-2 were recently confirmed for P. maniculatus [65,66]. Also in the top 10% were two rodents considered to be human commensals whose geographic ranges are expanding due to human activities: Rattus argentiventer (0.84) and R. tiomanicus (0.79) (electronic supplementary material, file S1) [85][86][87]. It is notable that many of these rodent species are preyed upon by carnivores, such as the red fox (Vulpes vulpes) or domestic cats (Felis catus) who themselves were predicted to have high zoonotic capacity by our model.…”

Section: (D) Rodentsmentioning

confidence: 91%

Predicting the zoonotic capacity of mammals to transmit SARS-CoV-2

et al. 2021

View full text Add to dashboard Cite

Back and forth transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) between humans and animals will establish wild reservoirs of virus that endanger long-term efforts to control COVID-19 in people and to protect vulnerable animal populations. Better targeting surveillance and laboratory experiments to validate zoonotic potential requires predicting high-risk host species. A major bottleneck to this effort is the few species with available sequences for angiotensin-converting enzyme 2 receptor, a key receptor required for viral cell entry. We overcome this bottleneck by combining species' ecological and biological traits with three-dimensional modelling of host-virus protein–protein interactions using machine learning. This approach enables predictions about the zoonotic capacity of SARS-CoV-2 for greater than 5000 mammals—an order of magnitude more species than previously possible. Our predictions are strongly corroborated by in vivo studies. The predicted zoonotic capacity and proximity to humans suggest enhanced transmission risk from several common mammals, and priority areas of geographic overlap between these species and global COVID-19 hotspots. With molecular data available for only a small fraction of potential animal hosts, linking data across biological scales offers a conceptual advance that may expand our predictive modelling capacity for zoonotic viruses with similarly unknown host ranges.

show abstract

“…Nanopore sequencing of SARV positive samples has revealed partial genome sequences of 671, 1326, and 677 nucleotides of the S, M, and L segments, respectively. To date, our results give the first molecular evidence of the presence of bat-related hantaviruses in the country, although mostly serological data are available, suggesting the presence of hantaviruses other than Mobatviruses in Malaysia [21,22,23].…”

Section: Resultsmentioning

confidence: 99%

Molecular Identification of a Novel Hantavirus in Malaysian Bronze Tube-Nosed Bats (Murina aenea)

Zana

Kemenesi

Buzás

et al. 2019

Viruses

View full text Add to dashboard Cite

In the past ten years, several novel hantaviruses were discovered in shrews, moles, and bats, suggesting the dispersal of hantaviruses in many animal taxa other than rodents during their evolution. Interestingly, the coevolutionary analyses of most recent studies have raised the possibility that nonrodents may have served as the primordial mammalian host and harboured the ancestors of rodent-borne hantaviruses as well. The aim of our study was to investigate the presence of hantaviruses in bat lung tissue homogenates originally collected for taxonomic purposes in Malaysia in 2015. Hantavirus-specific nested RT-PCR screening of 116 samples targeting the L segment of the virus has revealed the positivity of two lung tissue homogenates originating from two individuals, a female and a male of the Murina aenea bat species collected at the same site and sampling occasion. Nanopore sequencing of hantavirus positive samples resulted in partial genomic data from S, M, and L genome segments. The obtained results indicate molecular evidence for hantaviruses in the M. aenea bat species. Sequence analysis of the PCR amplicon and partial genome segments suggests that the identified virus may represent a novel species in the Mobatvirus genus within the Hantaviridae family. Our results provide additional genomic data to help extend our knowledge about the evolution of these viruses.

show abstract

Rodent Species Distribution and Hantavirus Seroprevalence in Residential and Forested areas of Sarawak, Malaysia

Cited by 9 publications

References 19 publications

Predicting the zoonotic capacity of mammals to transmit SARS-CoV-2

Predicting the zoonotic capacity of mammals to transmit SARS-CoV-2

Predicting the zoonotic capacity of mammals to transmit SARS-CoV-2

Molecular Identification of a Novel Hantavirus in Malaysian Bronze Tube-Nosed Bats (Murina aenea)

Contact Info

Product

Resources

About