Roedores silvestres como modelos experimentais da esquistossomose mansônica: Akodon arviculoides (Rodentia: Cricetidae)

Abstract

A infecção experimental do A. arviculoides através de diferentes vias de penetração das cercárias de Schistosoma mansoni (transcutânea e subeutânea) foi estudada pela cinética de eliminação de ovos nas fezes, pela recuperação dos vermes adultos (no sistema porta e nos vasos mesentéricos) e pelo oograma quantitativo. Demonstrou-se que a infecção do A. arviculoides assemelha-se à dos camundongos albinos que serviram de controle, quanto a eficácia das vias de penetração, ao habitat dos vermes adultos e ao oograma. Esses resultados sugerem que se avaliem outros aspectos da relação parasito-hospedeiro para que o A. arviculoides possa ser indicado como modelo experimental alternativo, nos estudos sobre a esquistossomose.

The outcome of acute schistosomiasis infection in adult mice with postnatal exposure to maternal malnutrition

“…In our study, all infected groups had higher numbers of immature eggs in the distal small intestine, which corroborates other studies (Costa & Katz 1982, Machado e Silva et al 1991, Martinez et al 2003. Adult PR offspring had a higher total number of eggs in their faeces and intestinal portions, as well as a higher number of eggs in all stages of development.…”

“…removed (Machado e Silva et al 1991). Segments were opened, washed and crushed between two glass slides to obtain a thin preparation.…”

Parasitological characteristics of Schistosoma mansoni infection in swiss mice with underlying malnutrition

“…It is well established that in well-fed mice, S. mansoni eggs are trapped mainly in the small intestine (Nyndo & Farah 1999). In this regard, about 50% of the eggs lodge in the distal segment of the small intestine (Costa & Katz 1982, Machado-Silva et al 1991. Meanwhile, our results showed that malnourished mice had a higher egg count in the proximal segment.…”

“…From each segment a sample (1 cm long) was obtained. A same procedure was taken for colon segment (Machado-Silva et al 1991). All fragments were crushed between two glass slides.…”

Assessment of Akodon cursor (Rodentia, Sigmodontinae) as permissive host to Schistosoma mansoni infection: morphology of adult worms

“…For this reason, some species of wild rodents have been introduced for captive conditions and were employed as natural-hosts animal models for schistosomiasis studies (Machado e Silva et al 1991, Maldonado Jr. et al 1994, Lenzi et al 1995, Ribeiro et al 1998.…”