Roentgenographic-Histologic Patterns of Calcification in Thyroid Nodules

Fujimoto, Yoshihide; Akisada, Masayoshi

doi:10.1507/endocrj1954.17.263

Cited by 11 publications

(4 citation statements)

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“…Hazard 7 and Lindsay 8 subsequently mentioned this variant in their reviews of thyroid tumors. Fujimoto and colleagues 9 described it in 1970 during a study of psammoma bodies in thyroid lesions, and in 1972, described seven cases of this variant. 9 Few studies in the literature have analyzed DSV, and all underline the diagnostic difficulty from clinically diffuse thyroid enlargement.…”

Section: Discussionmentioning

confidence: 99%

“…Fujimoto and colleagues 9 described it in 1970 during a study of psammoma bodies in thyroid lesions, and in 1972, described seven cases of this variant. 9 Few studies in the literature have analyzed DSV, and all underline the diagnostic difficulty from clinically diffuse thyroid enlargement. 10,11 In 1988, Hedinger and other pathologists at the World Health Organization Collaborating Center for the Histological Classification of Thyroid Tumors 12 No.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic Importance of Sclerosing Variant in Papillary Thyroid Carcinoma

Falvo

Giacomelli

D'Andrea

et al. 2006

The American Surgeon™

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The diffuse sclerosing variant (DSV) of papillary thyroid carcinoma is known for its high aggressiveness, high incidence of lymph node metastases, and high incidence of pulmonary metastases, and thus its consequently poorer prognosis. In this study, we undertook a retrospective analysis of papillary thyroid carcinomas to assess whether DSV can be considered a predictive factor for prognosis. We performed a retrospective evaluation of the Department's database of patients with papillary thyroid carcinoma who had undergone total thyroidectomy from January 1992 to December 2000. Group I consisted of 83 DSV patients and Group II was 168 pure papillary carcinoma (PC) patients. A significant prevalence of multinodular thyroid disorder on diagnosis was found for PC (P < 0.05), whereas with DSV, there was a significantly higher prevalence of post-thyroiditis nodular thyroid disorder than with PC (P < 0.001). The incidence of laterocervical lymph node pathology on diagnosis was significantly higher for DSV (P < 0.05). In 3.6 per cent of PC patients and 15.7 per cent of DSV patients, we observed recurrences in the regional lymph nodes (P < 0.001). We found 1.2 per cent distant metastases in PC patients and 7.2 per cent in DSV patients (P < 0.05). One PC patient (0.6%) and three DSV patients (3.6%) died of tumor-related causes (P < 0.05). Our study demonstrated that diffuse sclerosing carcinoma leads to a poorer prognosis to the extent that its classification as an autonomous clinical pathological entity is justified. In conclusion, we can state that DSV is a form of papillary thyroid tumor characterized by its higher aggressiveness, diffuse intrathyroid growth, and high incidence of lymph node and pulmonary metastasis. Ultimately, this means a poorer prognosis. In the presence of risk factors indicating a possible increase in biological aggressiveness, adequate postoperative treatment and close follow-up become essential.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prognostic Importance of Sclerosing Variant in Papillary Thyroid Carcinoma

Falvo

Giacomelli

D'Andrea

et al. 2006

The American Surgeon™

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“…This situation, however, is not alarming. First, such pathology is well diagnosed by imaging techniques for decades . Second, if the calcification occurs the goiter has a tendency to shrink and usually is not large in size, the condition known as dystrophic calcification .…”

Section: Discussionmentioning

confidence: 99%

“…First, such pathology is well diagnosed by imaging techniques for decades. 33,34 Second, if the calcification occurs the goiter has a tendency to shrink and usually is not large in size, the condition known as dystrophic calcification. [35][36][37] We encountered with such condition in three cases (4.3%) but usually it was not a complete egg shell calcification but separate calcified areas of the capsule.…”

Section: Discussionmentioning

confidence: 99%

Surgical approach to the intrathoracic goiter

Vaiman

Bekerman

Jabarin

et al. 2018

Laryngoscope Investig Oto

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ObjectiveIn a retrospective study, the authors analyzed the surgical approach to the intrathoracic goiter to avoid sternotomy or thoracotomy.MethodsWe selected 70 intrathoracic cases of multinodular goiter out of 988 cases of thyroidectomy and compared them with cervical goiter cases. Surgical technique, results, and postsurgical complications were assessed.ResultsThe analyzed cases presented the retrosternal goiter (n = 53; 75.7%), the retrotracheal goiter (n = 9; 12.8%), and the retroesophageal goiter (n = 8; 11.4%). Complaining of chest pressure or discomfort was specific for intrathoracic cases (50%; 35 of 70). All goiters except one were removed via cervical incision. The surgeons used head reclination and isthmus dissection when removing sizable goiters. Mean weight of goiters was 180 g. The recurrent laryngeal nerve was more often temporarily damaged in intrathoracic cases in comparison with cervical cases (4.3% vs. 2.8%, P = .04), but the difference in permanent injury was less significant (P = .09). The incidence of temporary hypoparathyroidism was significantly higher in intrathoracic cases (P = .01).ConclusionIn cases of multinodular goiter the goiters of various extensions can be successfully removed via the cervical incision in most of the cases even if they occupy the retrosternal, retrotracheal, or retroesophageal position. The transthoracic approaches and sternotomy might be justified in malignant cases.Level of Evidence4.

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Diffuse sclerosing variant of papillary carcinoma of the thyroid: Clinical importance, surgical treatment, and follow-up study

Fujimoto

Obara

Ito

et al. 1990

Cancer

105

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A diffuse sclerosing variant is not very rare among papillary carcinomas of the thyroid when the patients are female and younger than 30 years of age. The variant is characterized by diffuse involvement of one or both thyroid lobes, with dense sclerosis, patchy lymphocytic infiltration, and abundant psammoma bodies. Controversy still exists concerning its prognosis. We reviewed our experience with 14 patients treated between 1958 and 1988. All patients were young females, their age being from 10 to 28 years with a mean of 19.6. Hashimoto's thyroiditis had been suspected in nine patients before they came to our clinic. Nowadays the diagnosis of this cancer is possible when we have this entity in mind and detect abundant psammoma bodies either by ultrasonography or by soft-tissue roentgenography of the neck. Total thyroidectomy with modified neck dissection was carried out in eight patients, subtotal thyroidectomy with neck dissection in five, and lobectomy with neck dissection in one. All of them are alive and well without distant metastasis at a mean follow-up of 16 years. Because most of the patients with this variant of papillary carcinoma are young women and the prognosis is favorable, a complete resection without causing later recurrence, but also cosmetic and complication-free surgery, should be considered.

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Roentgenographic-Histologic Patterns of Calcification in Thyroid Nodules

Cited by 11 publications

References 4 publications

Prognostic Importance of Sclerosing Variant in Papillary Thyroid Carcinoma

Prognostic Importance of Sclerosing Variant in Papillary Thyroid Carcinoma

Surgical approach to the intrathoracic goiter

Diffuse sclerosing variant of papillary carcinoma of the thyroid: Clinical importance, surgical treatment, and follow-up study

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