Roentgenographic Manifestations of Klinefelter’s Syndrome

Ohsawa, Tadashi; Furuse, Makoto; KIKUCHI, YUZO; SUDA, YOSHIO; Tamiya, Takahiro; Hikita, Masahiro

doi:10.2214/ajr.112.1.178

Cited by 9 publications

(2 citation statements)

References 5 publications

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“…Several authors have reported BMD deficiency in patients with Klinefelter's syndrome using x-ray pictures for diagnosis (Lauder et al, 1975;Myhre et al, 1970;Ohsawa et al, 1971). We were now able to quantify BMD deficiency exactly, by using single-photon absorptiometry for measurement.…”

Section: Discussionmentioning

confidence: 90%

“…These comprise of increased stature, eunuchoid body proportions, small testes, testicular hyalinization with fibrosis and azoospermia (Klinefelter et al, 1942;Myhre et al, 1970). Previous publications have shown a deficiency of bone mineral density (BMD) and of cortical thickness in these patients, but they could neither state the instance nor extent of bone mineral loss or the cause of it (Lauder et al, 1975;Myhre et al, 1970;Ohsawa et al, 1971). The testosterone deficiency and the extra x-chromosome have been said to account for this.…”

Section: Introductionmentioning

confidence: 99%

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The Influence of Testosterone Substitution on Bone Mineral Density in Patients with Klinefelter's Syndrome

Kübler

Schulz²,

Cordes³

et al. 2009

Exp Clin Endocrinol Diabetes

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The aim of this study was to clarify the extent of bone mineral deficiency in patients with Klinefelter's syndrome on the premise that testosterone substitution could prevent this deficiency. Bone mineral density was measured by single-photon absorptiometry in 42 patients with Klinefelter's syndrome, (21 patients without therapy, 10 with testosterone substitution before the age of 20 and 11 patients with testosterone substitution beginning after the age of 20). We found significantly lower bone mineral density in patients without therapy and in patients when the therapy began later compared to normal individuals. Patients with early therapy showed a high proportion of normal values of bone mineral density. We found a positive correlation between bone mineral density and plasma testosterone and a negative correlation between plasma testosterone and age for patients without therapy. These findings suggest that low testosterone levels before or during puberty cause inadequate bone development and low bone mineral density in Klinefelter's syndrome. Only early testosterone substitution may prevent bone mineral deficiency. Later substitution no longer affects bone mineral density.

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Section: Discussionmentioning

confidence: 90%