Roentgenography of Urinary Tract During Excretion of Sodium Iodid

Osborne, Earl D.

doi:10.1001/jama.1983.03340200082037

Cited by 29 publications

(22 citation statements)

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“…Intravenous urography has been the procedure of choice for evaluation of renal colic since it was first performed in 1923 1. It provides structural as well as functional information of the urinary tract.…”

Section: Discussionmentioning

confidence: 99%

Is spiral computed tomography the imaging modality of choice for renal colic?

2001

Postgraduate Medical Journal

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A 23 year old man presented to the casualty department with right periorbital oedema. A diagnosis of urticaria was made, antihistamines were prescribed, and he was discharged home. Within 24 hours he returned complaining of increased facial swelling and dysphagia, and a medical opinion was sought. He denied recent facial trauma, or insect stings. Further inquiry revealed that he had suVered a similar episode nine months earlier which had involved swelling of his hands and feet. These areas were not itchy or red. His past history included recurrent bouts of abdominal pain associated with distension and vomiting requiring numerous hospital admissions under the care of diVerent consultants over the previous 14 years. A diagnosis of abdominal migraine was frequently recorded. There were no obvious precipitating factors and the bouts resolved spontaneously over a period of a few days. Detailed family history uncovered several members with similar symptoms and an inheritance pattern along the maternal line. Examination revealed a slim built, normotensive 23 year old man with bilateral periorbital, perioral, and pharyngeal oedema. He was comfortable at rest with no drooling, dyspnoea, or wheeze (fig 1). Routine investigations showed a normal full blood count, urea and electrolytes, liver function tests, and chest x ray film. The suspected diagnosis of C1 esterase inhibitor (C1 INH) deficiency was confirmed with low C1 INH and C4 concentrations at 0.08 g/l (normal 0.15-0.35) and <0.06 g/l (normal 0.20-0.60) respectively.In view of the frequency and severity of his symptoms he was started on prophylactic treatment with danazol. He was advised that he would require intravenous infusions of C1 INH concentrate as prophylaxis before any future surgical intervention and review would be needed before future dental work. He was discharged with a Medic Alert bracelet and arrangements were made to screen other family members. To date, three years later, there have been no further relapses.

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Section: Discussionmentioning

confidence: 99%

Is spiral computed tomography the imaging modality of choice for renal colic?

2001

Postgraduate Medical Journal

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“…In 1923 a very important paper was published by Osborne et al [10]. They reported that inorganic iodides enhance renal and urinary tract X-ray images.…”

Section: Imaging Of Structure and Function Of The Urinary Systemmentioning

confidence: 99%

The Discovery of Renal Contrast Media in Berlin

Hierholzer

2002

Am J Nephrol

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After X-rays were detected and cystoscopes had become available, progress in nephrology depended on the development of contrast media which would permit imaging of the kidneys and the urinary system. We describe how A. Binz and C. Räth, two chemists at the Agricultural Academy in Berlin, synthesized iodinated derivatives which were potent chemotherapeutics. Moses Swick tested the substances in the clinics of L. Lichtwitz (Hamburg) and A. von Lichtenberg (Berlin) and discovered a rapid renal excretion. He also observed that an iodinated N-acetylated derivative, later named Uro-Selectan, amplified X-ray contrast after intravenous application. With this substance and other derivatives which were produced by Schering-Kahlbaum AG, the door was open for excretion urography.

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“…He apparently met Alexis Carrel [18,19], who had moved from Lyon to New York, and it is possible that this contact stimulated Unger to focus his interest on kidney transplantation and even tually to test its therapeutic usefulness. [26]; for details see text. 444 Hierholzer/Winau Pioneer Nephrologists of Berlin…”

Section: Development Of Kidney Transplantmentioning

confidence: 99%

“…The situation changed when Os borne treated syphilic patients with large doses of iodides (oral and intravenous administration) and observed that the compounds were rapidly excreted by the kidneys. In 1923 he reported -together with Rowntree -that in cer tain cases the contours of the ureters and bladder and even the outlines of the kidneys could be visualized [26]. Roseno [27] tried to detoxify Na iodide by coupling to urea (Pyelognost) and reported somewhat better results.…”

Section: Excretion Urographymentioning

confidence: 99%