Roentgenological Evaluation of Achilles-Tendon Xanthomatosis

Gattereau, A; Davignon, Jean; Lévesque, H

doi:10.1016/s0140-6736(71)92271-9

Cited by 13 publications

(9 citation statements)

References 2 publications

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“…Among the case–control papers, there were five studies that recruited the case group based on tendon structure or tendon pain, 6 29 32–34 and three studies that recruited the case group based on lipid abnormalities. 35–37 There were seven studies of FH where only the control group was included. 13 14 38–42 Two studies examined the cross-sectional relationship between tendon health and lipid profiles.…”

Section: Resultsmentioning

confidence: 99%

Is higher serum cholesterol associated with altered tendon structure or tendon pain? A systematic review

et al. 2015

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BackgroundTendon pain occurs in individuals with extreme cholesterol levels (familial hypercholesterolaemia). It is unclear whether the association with tendon pain is strong with less extreme elevations of cholesterol.ObjectiveTo determine whether lipid levels are associated with abnormal tendon structure or the presence of tendon pain.MethodsWe conducted a systematic review and meta-analysis. Relevant articles were found through an electronic search of 6 medical databases—MEDLINE, Cochrane, AMED, EMBASE, Web of Science and Scopus. We included all case–control or cross-sectional studies with data describing (1) lipid levels or use of lipid-lowering drugs and (2) tendon structure or tendon pain.Results17 studies (2612 participants) were eligible for inclusion in the review. People with altered tendon structure or tendon pain had significantly higher total cholesterol, low-density lipoprotein cholesterol and triglycerides, as well as lower high-density lipoprotein cholesterol; with mean difference values of 0.66, 1.00, 0.33, and −0.19 mmol/L, respectively.ConclusionsThe results of this review indicate that a relationship exists between an individual’s lipid profile and tendon health. However, further longitudinal studies are required to determine whether a cause and effect relationship exists between tendon structure and lipid levels. This could lead to advancement in the understanding of the pathoaetiology and thus treatment of tendinopathy.

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Section: Resultsmentioning

confidence: 99%

Is higher serum cholesterol associated with altered tendon structure or tendon pain? A systematic review

et al. 2015

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“…Previous studies [3,4,8,9,12,15,18,21] have used other techniques to visualize Achilles tendon xanthomas. Yuzawa et al [21] compared ultrasonography with conventional radiography and found a strong correlation; the mean thickness of the Achilles tendons of their patients was higher than that of their controls but it overlapped.…”

Section: Discussionmentioning

confidence: 99%

“…Imaging techniques like (xero)radiography, computed tomography, and ultrasonography (US) have been used to visualize Achilles tendon xanthomas [3,4,8,9,12,15,18,21]. In this study we compared magnetic resonance (MR) imaging features of Achilles tendon xanthomas in patients with familial hypercholesterolemia with images from a control group.…”

mentioning

confidence: 99%

Magnetic resonance imaging of Achilles tendon xanthomas in familial hypercholesterolemia

Liem

Leuven²,

Bloem

et al. 1992

Skeletal Radiol.

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The demonstration of tendon xanthomas is helpful in diagnosing heterozygous familial hypercholesterolemia, but in many patients lipid may accumulate without clinical abnormality being present. We investigated the possibility of detecting the lipid element with magnetic resonance (MR) imaging in seven patients with familial hypercholesterolemia and six controls. Although the mean relative signal intensities measured on long TR/TE spin echo sequences of the tendon were significantly higher in patients than in controls, the lack of such elevation does not rule out the presence of such lesions. In vitro measurements indicated that the signal intensity of triglycerides was quenched by cholesterolesters. The anatomic findings of MR imaging were compared with those of ultrasonography (US), showing excellent correlation in measurements between MR images and US [r(S) = 0.95 and 0.97 respectively]. MR imaging and US provide equal information on the anatomy of the Achilles tendon; as an abnormally increased signal intensity within the xanthoma on MRI was found in only a minority of our patients, the value of MRI in the demonstration of Achilles tendon xanthomas is limited when using conventional T1 and T2 spin echo sequences.

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“…They could demonstrate the enlargement of Achilles tendon. Unfortunately, detecting internal structural abnormalities before tendon enlargement occurs has not been successful 5 6…”

Section: Discussionmentioning

confidence: 99%

Multiple tendon xanthomas in patient with heterozygous familial hypercholesterolaemia: sonographic and MRI findings

et al. 2013

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Tendon xanthomas are a component of familial hypercholesterolaemia, which is a hereditary disease and characterised by elevated low-density lipo protein cholesterol plasma levels and premature coronary artery disease. Tendon xanthomas are diagnostic for heterozygous familial hypercholesterolaemia (HFH) and they mostly occur in Achilles tendon. Sonography and MRI are superior to clinical assessment and are useful in detecting tendon xanthomas. In this report, we present ultrasonographic and MRI findings of multiple tendon xanthomas in a case of HFH.

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Roentgenological Evaluation of Achilles-Tendon Xanthomatosis

Cited by 13 publications

References 2 publications

Is higher serum cholesterol associated with altered tendon structure or tendon pain? A systematic review

Is higher serum cholesterol associated with altered tendon structure or tendon pain? A systematic review

Magnetic resonance imaging of Achilles tendon xanthomas in familial hypercholesterolemia

Multiple tendon xanthomas in patient with heterozygous familial hypercholesterolaemia: sonographic and MRI findings

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