Roflumilast alleviates adenine-induced chronic kidney disease by regulating inflammatory biomarkers

Multi-omics analysis of kidney tissue metabolome and proteome reveals the protective effect of sheep milk against adenine-induced chronic kidney disease in mice

“…62 Adenine also induces renal dysfunction, characterized by a considerable increase in creatinine, urea, and uric acid levels. 63,64 Furthermore, adenine-induced renal failure results in the enlargement of mouse kidneys, thereby increasing kidney index, a key indicator of renal health. 65 Interestingly, the current data suggest that sheep milk has a significant renal protective effect mediated by its ability to mitigate injury biomarkers.…”