Rola brodawczaka ludzkiego w patologii jamy ustnej — przegląd piśmiennictwa

Radzki, Dominik; Baiduk, Karolina; Burzyńska, Martyna; Lisai, Anhelina; Pańszczyk, Katarzyna; Bochniak, Mariusz; Kusiak, Aida

doi:10.20883/df.2018.9

Cited by 2 publications

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“…Oral leukoplakia, which is the most common multifactorial premalignant lesion of the oral mucosa, may be induced by the inveterate use of tobacco in either smoked or smokeless form [ 114 ]; it has been shown that tobacco users have higher epithelial expression of MMPs, which imply their involvement in tobacco carcinogenesis [ 115 ]. High-risk human papillomavirus (HR-HPV) infection may be another cause of leukoplakia and carcinoma development [ 116 , 117 , 118 ]; HR-HPV E6 and E7 oncoproteins have an impact on cell homeostasis through inactivation of the p53 and pRB tumor suppressors, which leads to cellular immortalization [ 114 ], but it is not enough to explain the occurrence of cancer. Modification of the ECM by MMPs may represent another factor necessary for the establishment and progression of tumors [ 119 ].…”

Section: A Brief Glance At the Role Of Matrix Metalloproteinases In T...mentioning

confidence: 99%

Matrix Metalloproteinases in the Periodontium—Vital in Tissue Turnover and Unfortunate in Periodontitis

Radzki,

Negri,

Kusiak

et al. 2024

IJMS

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The extracellular matrix (ECM) is a complex non-cellular three-dimensional macromolecular network present within all tissues and organs, forming the foundation on which cells sit, and composed of proteins (such as collagen), glycosaminoglycans, proteoglycans, minerals, and water. The ECM provides a fundamental framework for the cellular constituents of tissue and biochemical support to surrounding cells. The ECM is a highly dynamic structure that is constantly being remodeled. Matrix metalloproteinases (MMPs) are among the most important proteolytic enzymes of the ECM and are capable of degrading all ECM molecules. MMPs play a relevant role in physiological as well as pathological processes; MMPs participate in embryogenesis, morphogenesis, wound healing, and tissue remodeling, and therefore, their impaired activity may result in several problems. MMP activity is also associated with chronic inflammation, tissue breakdown, fibrosis, and cancer invasion and metastasis. The periodontium is a unique anatomical site, composed of a variety of connective tissues, created by the ECM. During periodontitis, a chronic inflammation affecting the periodontium, increased presence and activity of MMPs is observed, resulting in irreversible losses of periodontal tissues. MMP expression and activity may be controlled in various ways, one of which is the inhibition of their activity by an endogenous group of tissue inhibitors of metalloproteinases (TIMPs), as well as reversion-inducing cysteine-rich protein with Kazal motifs (RECK).

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Section: A Brief Glance At the Role Of Matrix Metalloproteinases In T...mentioning

confidence: 99%

Matrix Metalloproteinases in the Periodontium—Vital in Tissue Turnover and Unfortunate in Periodontitis

Radzki,

Negri,

Kusiak

et al. 2024

IJMS

Self Cite

View full text Add to dashboard Cite

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Salivary HPV infection in healthy people

Radwan-Oczko

Owczarek-Drabińska

Szczygielska

et al. 2022

Postępy Higieny I Medycyny Doświadczalnej

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Introduction In recent years, interest in human papillomavirus infections as a causative factor in epithelial cancer development has grown. Literature indicates that HPV involvement in malignant transformations in oral mucosa can vary significantly, from 0 up to 87%. The aim of our study was to detect the prevalence of salivary HPV infection among generally healthy adults. Materials and Methods The examination involved 139 patients, from whom 139 whole, 1.5ml saliva samples were obtained. HPV DNA was detected by the nested PCR technique. To visualize the PCR products electrophoresis reactions were carried out. Results Sample analysis showed that DNA for HPV was detected in 14 patients: 11 positive results were obtained from men, and 3 from women. This yields a high infection rate: 10.07%. Conclusions The HPV prevalence in the male group was more than twice as high as in the female group. Also, subclinical oral HPV infection was detected more frequently in young (19–39 years old) and older (=>60 years old) adults.

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Rola brodawczaka ludzkiego w patologii jamy ustnej — przegląd piśmiennictwa

Cited by 2 publications

References 0 publications

Matrix Metalloproteinases in the Periodontium—Vital in Tissue Turnover and Unfortunate in Periodontitis

Matrix Metalloproteinases in the Periodontium—Vital in Tissue Turnover and Unfortunate in Periodontitis

Salivary HPV infection in healthy people

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