Role and Importance of Chlamydia Trachomatis in Pregnant Patients

Angelova, M; Kovachev, E; Tsankova, Veselina; Koleva, Iliana; Mangarova, Silvia

doi:10.3889/oamjms.2016.077

Cited by 8 publications

(6 citation statements)

References 5 publications

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“…They have found that the early diagnosis and treatment of chlamydial infections can prevent the infection to the new born. They have suggested that the preventive examinations should be considered as a priority for early detection of asymptomatic chlamydial infection in the conduct of antenatal care (33). The Chlamydial infection is also associated with an increased risk for transmission or acquisition of human immunodeficiency virus (HIV) and is also attributed to be a risk factor for development of carcinoma cervix (34).…”

Section: Discussionmentioning

confidence: 99%

Cytological Detection of Chlamydial Infection Associated With Different Gynaecological Diseases

Tandon¹,

Misra²,

Srivastava³

et al. 2018

EJMR

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Chlamydia trachomatis is the most common bacterial sexually transmitted diseases (STD) and is associated with gynecological disorders like pelvic inflammatory disease (PID), infertility and habitual abortion. The present study was carried out in 85 women who had complaints of symptoms like PID, infertility and habitual abortion. These women were recruited from the Gynaecology OPD of GSVM Medical College, Kanpur between January 2008 to September 2009. Both routine Pap smear examination and Chlamydial antigen detection test was performed in the sample collected from the cervix. Chlamydia was detected in 22 of the 85 cases (25.8%). Inflammatory changes were commonly associated with Chlamydia (77.2%) while squamous intraepithelial lesion (SIL) of cervix was seen in 22.8% of cases. The Chlamydia was very common in the younger sexually active group of 21-30 years and was associated with PID in 30.7% of cases, with infertility in 21.0% and with habitual abortion in 14.2% of cases. Routine cytological screening is needed in all symptomatic women especially those complaining of pain in lower abdomen and vaginal discharge and also asymptomatic women to detect Chlamydia to facilitate their timely treatment.

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Section: Discussionmentioning

confidence: 99%

Cytological Detection of Chlamydial Infection Associated With Different Gynaecological Diseases

Tandon¹,

Misra²,

Srivastava³

et al. 2018

EJMR

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“…No Brasil, as prevalências variam de 2,1% a 13,6% em estudos onde a população de mulheres estava abaixo dos 25 anos e em adolescentes, mulheres grávidas e em mulheres vivendo com HIV/AIDS 13,19,20,21 . Um estudo envolvendo mulheres submetidas à reprodução assistida, mostra uma frequência bem superior aos estudos citados anteriormente (40,0%), podendo ser este um indicativo de que a C. trachomatis é uma potente bactéria causadora de infertilidade em mulheres 5 .…”

Section: Discussão E Conclusãounclassified

“…Quanto aos outros fatores sociodemográficos, verificamos a presença de infecção por C. trachomatis em pacientes que relataram ter um único parceiro (61,6%), casadas ou vivendo em união estável (58,4%), de raça parda e ou negra (88,0%) e com escolaridade de 1 a 9 nos (62,4%), o que concorda com os dados obtidos de relatos na literatura 13,19,21,25 . Entretanto, uma discordância é evidenciada nos resultados encontrados em 6,20 , onde uma intensa atividade sexual com múltiplos parceiros foi apontado como fator de risco.…”

Section: Discussão E Conclusãounclassified

Análise da infecção por Chlamydia trachomatis e fatores associados em mulheres portadoras do Vírus da Imunodeficiência Humana (HIV) e alto índice de coinfecção por Papillomavírus humano (HPV) no Maranhão/ Analysis of Chlamydia trachomatis infection and associated factors in women with Human Immunodeficiency Virus (HIV) and high rate of Human Papillomavirus (HPV) coinfection in Maranhão

Grassi¹,

Costa²,

Grassi³

et al. 2021

BJDV

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RESUMOAs Infecções Sexualmente Transmissíveis (ISTs) são causadas por mais de 30 patógenos diferentes e estima-se que possam infectar 500 milhões de pessoas ao ano. Infecções causadas por Chlamydia trachomatis (clamídia) é uma das ISTs mais frequente e séria, uma vez que e na maioria dos casos é assintomática e quando não tratada, pode causar graves problemas no sistema gênito-urinário, levando inclusive a infertilidade. A coinfecção com o HIV tem sido relacionada com um aumento da transmissão do vírus e da aceleração da doença. Outra IST relacionada com aumento da transmissão de HIV é o Papillomavírus humano (HPV). No Brasil, a falta de notificação compulsória de clamídia, ou de HPV dificulta a obtenção de informações. Assim, estudos epidemiológicos que fornecem tais informações são importantes para direcionar políticas e ações de saúde. O objetivo deste estudo foi analisar a presença de infecção por Chlamydia trachomatis e a associação de fatores sociodemográficos e clínicos, inclusive coinfecção com HPV em mulheres infectadas com HIV/AIDS no Maranhão. Para isso, foram analisadas 125 amostras cervicais de mulheres em acompanhamento no sistema público de saúde. Para identificar a infecção, o DNA de C. trachomatis foi detectado por reação em cadeia de polimerase (PCR). Foi possível estimar uma frequência de 16,8% de C. trachomatis na população estudada. A coinfecção também com HPV foi de 10,8%. O fator de risco associado foi com a idade superior a 25 anos (p=0,038). Esse estudo mostra que a frequência de infecção por C. trachomatis na população com HIV e com alta frequência de HPV, não foi maior do que a relatada na população em geral e a única associação foi com a idade . Isso reforça as indicações de políticas de saúde para esta faixa etária independente da presença ou não de HIV e/ou HPV.

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“…C. trachomatis can be treated easily and effectively with a single-dose therapy of azithromycin, even during pregnancy [46,49]. Implementation of screening and treatment of pregnant women in the USA has led to a decrease of C. trachomatis infection of the newborn, and morbidity such as pre-term rupture of the membranes and pre-term birth [47,50]. Additionally, prevention due to vaccination could be considered in the future [51][52][53].…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Chlamydia trachomatisduring pregnancy and childhood asthma-related morbidity: a population-based prospective cohort

et al. 2020

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IntroductionChlamydia trachomatis is the most commonly reported sexually transmitted disease and although infection during pregnancy is associated with neonatal complications, long-term respiratory consequences are unknown. We aimed to determine whether C. trachomatis infection during pregnancy is associated with asthma-related symptoms across childhoodMethodsThis study among 2475 children and their mothers was embedded in a population-based prospective cohort study. Maternal urine samples were tested for C. trachomatis infection during pregnancy. Questionnaires provided information on childhood physician-attended lower respiratory tract infections and wheezing, and current asthma at age 10 years. Lung function was measured by spirometry at age 10 years.ResultsThe prevalence of C. trachomatis infection during pregnancy was 3.2% (78 out of 2475). C. trachomatis infection during pregnancy was not associated with lower respiratory tract infections until age 6 years, but was associated with a higher odds of wheezing in children until age 10 years (OR 1.50 (95% CI 1.10–2.03)). C. trachomatis infection during pregnancy was associated with an increased odds of asthma (OR 2.29 (95% CI 1.02–5.13)), and with a lower forced expiratory volume in 1 s/forced vital capacity and forced expiratory flow at 75% of forced vital capacity (z-score difference −0.28 (95% CI −0.52– −0.04) and −0.24 (95% CI −0.46– −0.01), respectively) in children at age 10 years. The observed associations were only partly explained by mode of delivery, gestational age at birth or birthweight.ConclusionsC. trachomatis infection during pregnancy is associated with increased odds of wheezing, asthma and impaired lung function. The causality of the observed associations and potential underlying mechanisms need to be explored.

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Role and Importance of Chlamydia Trachomatis in Pregnant Patients

Cited by 8 publications

References 5 publications

Cytological Detection of Chlamydial Infection Associated With Different Gynaecological Diseases

Cytological Detection of Chlamydial Infection Associated With Different Gynaecological Diseases

Chlamydia trachomatisduring pregnancy and childhood asthma-related morbidity: a population-based prospective cohort

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