Rôle de la chimiothérapie dans le cancer de la vessie

Fiard, G.; Pavillet, J.

doi:10.1016/j.purol.2015.06.011

Cited by 2 publications

(5 citation statements)

References 6 publications

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“…29 The prognosis of patients suffering advanced BCa is poor regardless of treatment methods. 5,7 Therefore, accurate diagnosis in early stage is an essential for improving the prognosis of patients with BCa.…”

Section: Discussionmentioning

confidence: 99%

“…BCa is the most common transitional epithelial cancer and accounts for the first incidence of urogenital tumors in China . The prognosis of patients suffering advanced BCa is poor regardless of treatment methods . Therefore, accurate diagnosis in early stage is an essential for improving the prognosis of patients with BCa.…”

Section: Discussionmentioning

confidence: 99%

“…3 On the basis of the malignant biological behavior of BCa, patients initially diagnosed with nonmuscular invasive cancer were prone to recurrence and progression after local resection and intravesical instillation, 4 while patients suffered muscleinvasive cancer remain, have poor prognosis regardless of related treatments, including radical cystectomy, chemical therapies, and even radiotherapy. [5][6][7] Many oncogenes and tumor suppressor genes contribute to the pathogenesis of BCa. Therefore, it is essential to understand the specific molecular mechanism of cancer growth and metastasis and further identify novel therapeutic targets which can strengthen treating methods for patients suffering BCa.…”

Section: Introductionmentioning

confidence: 99%

“…The new incidence of BCa cases has declined over the past decade, but the fatality rate has not decreased in the United States, especially for transitional cell carcinoma . On the basis of the malignant biological behavior of BCa, patients initially diagnosed with nonmuscular invasive cancer were prone to recurrence and progression after local resection and intravesical instillation,while patients suffered muscle‐invasive cancer remain, have poor prognosis regardless of related treatments, including radical cystectomy, chemical therapies, and even radiotherapy . Many oncogenes and tumor suppressor genes contribute to the pathogenesis of BCa.…”

Section: Introductionmentioning

confidence: 99%

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miR‐30e‐5p suppresses cell proliferation and migration in bladder cancer through regulating metadherin

Zhang

Qin

Jiang

et al. 2019

J of Cellular Biochemistry

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Recent studies have suggested that miR‐30e‐5p is dysregulated in several human carcinomas; however, the mechanism of miR‐30e‐5p in bladder cancer (BCa) remains unknown. Here, we confirmed that the expression of miR‐30e‐5p was decreased in human BCa specimens and cell lines by quantitative reverse‐transcription polymerase chain reaction (qRT‐PCR). Upregulation of miR‐30e‐5p decreased the proliferation and migration in T24 and UM‐UC‐3 cells. Metadherin (MTDH) was a potential target for miR‐30e‐5p through bioinformatics analysis. Dual‐luciferase assays were conducted to validate the interaction between miR‐30e‐5p and MTDH, which demonstrates that the relative luciferase activity was significantly downregulated after transfected miR‐30e‐5p mimic compared with control mimic in 293T cells. We also detected that whether silencing of MTDH by using small interfering(si)‐MTDH matched effects caused by miR‐30e‐5p overexpression in BCa cells lines by Cell Counting Kit‐8 (CCK‐8), colony formation, and transwell assay, and we found the effects of silencing of MTDH same as miR‐30e‐5p overexpression. Furthermore, we verified that the restoration of MTDH in miR‐30e‐5p‐overexpressed BCa cells rescued the inhibitory effects of miR‐30e‐5p. In conclusion, these results demonstrated that miR‐30e‐5p may inhibit BCa cells growth and invasiveness by targeting MTDH and may be a promising therapeutic agent for treating clinical BCa patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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miR‐30e‐5p suppresses cell proliferation and migration in bladder cancer through regulating metadherin

Zhang

Qin

Jiang

et al. 2019

J of Cellular Biochemistry

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“…While follow-up studies concerning hypospadias surgical complication rates have declined in the past several years, the studies available indicate that complication rates are 50 percent and above (Bauer and Truffer 2015: 10;Long et al 2017: 852). According to Christopher Long and colleagues, surgical complications are more frequent in midshaft, penoscrotal, and perineal repairs when compared to distal repairs, but the "overall complication rate was 56 percent" (2017: 852): 56 percent of boys who were subjected to surgeries that were intended to repair their ostensibly disabled penises dealt, and continue to deal with, various disabilities (see also McNamara et al 2015;Safwat et al 2013;Salle et al 2016;Stanasel et al 2015).…”

Section: Intersex Hypospadias and The Consequences Of Compulsory Dymentioning

confidence: 99%

Resisting the Demand to Stand

Orr

2019

Boyhood Studies

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How sex-segregated bathrooms negatively impact trans, genderqueer, nonbinary, queer, and gender-nonconforming people has been extensively studied, yet few have considered how intersex people are subjected to bathroom violence. To begin broadening this conversation, I focus on the medical management of boys with the intersex variation hypospadias and demonstrate that anxieties around bathrooms extend beyond the bathroom walls-into surgical theatersand are not simply a trans or queer issue. Anxieties about bathrooms and hegemonic urinary masculine behavior inform the violent medical maltreatment of intersex boys with hypospadias; they are subjected to shaming, disabling, and invasive procedures in the hope they will reinforce compulsory dyadism and able-bodiedness, as well as exhibit hegemonic heteromasculine behaviors, namely standing to urinate. Because of discriminatory, gratuitous surgical interventions, the bathroom and urination become sites of pain and trauma for these boys. In turn, these boys' sense of masculine belonging are undermined or destroyed.When analyzing bathrooms as both a litmus test for biological sex and volatile sites of gender policing, the discrimination that trans, genderqueer, nonbinary, queer, and gender-nonconforming people face are understandably central (see Cavanagh 2010; Halberstam 2005; Swales 2018). These individuals are subjected to various forms of cissexist, homophobic, queerphobic, and heterosexist violence: physical, sexual, verbal, and state-sanctioned. This "bathroom problem" (Halberstam 2005: 20), however, extends beyond bathroom walls and is not simply a trans or queer issue. Anxieties about bathrooms and hegemonic urinary masculine behavior inform the violent medical maltreatment of intersex boys with hypospadias. 1 These boys' experiences of pathologization must be integrated into analyses of the bathroom problem. In this article, I therefore extend conversations about the bathroom beyond the realm of trans and queer studies and demonstrate Boyhood Studies 12, no. 2 (Winter 2019): 89-113

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Rôle de la chimiothérapie dans le cancer de la vessie

Cited by 2 publications

References 6 publications

miR‐30e‐5p suppresses cell proliferation and migration in bladder cancer through regulating metadherin

miR‐30e‐5p suppresses cell proliferation and migration in bladder cancer through regulating metadherin

Resisting the Demand to Stand

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