2020
DOI: 10.1016/j.jns.2020.117159
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Role for OCT in detecting hemi-macular ganglion cell layer thinning in patients with multiple sclerosis and related demyelinating diseases

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Cited by 7 publications
(13 citation statements)
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“…Optical coherence tomography (OCT) has been used to detect damage to the anterior visual pathway (retrograde TSD), 15 and RNFL changes have been reported in DON 16,17 . Diffusion‐tensor imaging (DTI) has been widely applied in studying various visual pathway‐related disorders owing to its advantage of non‐invasively and accurately detecting the microstructural integrity of the neural pathways associated with vision 18–21 .…”
mentioning
confidence: 99%
“…Optical coherence tomography (OCT) has been used to detect damage to the anterior visual pathway (retrograde TSD), 15 and RNFL changes have been reported in DON 16,17 . Diffusion‐tensor imaging (DTI) has been widely applied in studying various visual pathway‐related disorders owing to its advantage of non‐invasively and accurately detecting the microstructural integrity of the neural pathways associated with vision 18–21 .…”
mentioning
confidence: 99%
“…Retinal ganglion cell loss measured by either OCT of the peripapillary RNFL or macular GCC has been proposed to be useful as a biomarker for disease activity or progression in a wide variety of neurologic disease including multiple sclerosis (22,23), Alzheimer disease (24), and Parkinson disease (25). Both direct effects of the disease on ganglion cells (16) and transsynaptic degeneration secondary to loss of cortical neurons (22) may contribute to observed effects. An understanding of the time course and mechanisms of transsynaptic degeneration is critical to use GCC thickness in monitoring disease activity and progression and the use of this parameter as a therapeutic target in development of novel treatment modalities.…”
Section: Discussionmentioning
confidence: 99%
“…Retinal ganglion cell loss measured by either OCT of the peripapillary RNFL or macular GCC has been proposed to be useful as a biomarker for disease activity or progression in a wide variety of neurologic disease including multiple sclerosis (22,23), Alzheimer disease (24), and Parkinson disease (25). Both direct effects of the disease on ganglion cells (16) and transsynaptic degeneration secondary to loss of cortical neurons (22) may contribute to observed effects.…”
Section: Discussionmentioning
confidence: 99%
“…Given the retinotopic organization of the visual system, the pattern of atrophy that would be expected at the optic disc is temporal thinning in the ipsilateral eye and a bow-tie pattern of atrophy in the contralateral eye, whereas the macula would be expected to show a homonymous hemi-macular pattern of atrophy (temporal hemi-atrophy in the ipsilateral eye and nasal hemi-atrophy in the contralateral eye). 21 These findings can be caused by a lesion in the optic radiations and are reflected in the pattern of peripapillary RNFL and GCIPL loss, respectively, as measured by OCT ( Figure 2 ).
Figure 2 MRI and OCT findings in three patients ( A, B, C ) with multiple sclerosis and homonymous, hemi-macular ganglion cell + inner plexiform layer (GCIPL) atrophy in conjunction with posterior visual pathway lesions, a pattern which is thought to be indicative of retrograde trans-synaptic degeneration.
…”
Section: Retrograde Trans-synaptic Degeneration In the Visual Pathway...mentioning
confidence: 99%
“…Given the retinotopic organization of the visual system, the pattern of atrophy that would be expected at the optic disc is temporal thinning in the ipsilateral eye and a bow-tie pattern of atrophy in the contralateral eye, whereas the macula would be expected to show a homonymous hemi-macular pattern of atrophy (temporal hemi-atrophy in the ipsilateral eye and nasal hemi-atrophy in the contralateral eye). 21 These findings can be caused by a lesion in the optic radiations and are reflected in the pattern of peripapillary RNFL and GCIPL loss, respectively, as measured by OCT (Figure 2). Al-Louzi et al reported a case series of six PwMS with posterior visual pathway lesions (four with lesions in the occipital white matter and two with lesions in the thalamus) who were found to have homonymous, hemi-macular pattern of GCIPL thinning on OCT, three of which also had corresponding homonymous hemi-macular microcystic macular pathology (MMP) of the inner nuclear layer (INL) in the same distribution as the hemi-macular GCIPL thinning.…”
Section: Retrograde Trans-synaptic Degeneration In the Visual Pathway...mentioning
confidence: 99%