Role for suppressor T cells in the pathogenesis of autoimmune diseases (including rheumatoid arthritis). Facts and hypotheses

Berthelot, Jean‐Marie; Maugars, Yves

doi:10.1016/j.jbspin.2003.11.004

Cited by 15 publications

(14 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This observed stimulatory effect of rapamycin on this Treg subset with in vitro-confirmed immunosuppressive activity is consistent with different in vitro and in vivo studies carried out both in rodents and humans [4,[9][10][11]33,34]. Nonetheless, the accumulation of CD4þCD25 þ Foxp3þ T cells in the CNS during remission phases of EAE in rats [35] suggests that these cells may be involved in dampening disease activity and that the capacity of rapamycin to expand them may be one of the mechanisms by which the drug exerts its therapeutic effects in this model.…”

Section: Discussionsupporting

confidence: 91%

“…nTregs and iTregs are capable of controlling the development and activity of pathogenic effector T cells during autoimmune diseases through cell-to-cell contact or cytokine-dependent pathways, respectively [3,4]. That defective Treg function may be important in the pathogenesis of MS and its rodent models is consistent with several studies.…”

Section: Introductionsupporting

confidence: 79%

“…Its mechanism of action involves the inhibition of the protein kinase activity of the mammalian target of rapamycin (mTOR) through the binding to FKBP12, which in turn reduces protein phosphorylation and cell cycle progression [24]. Importantly, rapamycin does not block proliferation in all T cell subtypes and Tregs constitute one of these sub-populations that is not blocked [4,10,25,26].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Treatment with rapamycin ameliorates clinical and histological signs of protracted relapsing experimental allergic encephalomyelitis in Dark Agouti rats and induces expansion of peripheral CD4+CD25+Foxp3+ regulatory T cells

Donia

Mangano

Amoroso

et al. 2009

Journal of Autoimmunity

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 91%

Section: Introductionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Treatment with rapamycin ameliorates clinical and histological signs of protracted relapsing experimental allergic encephalomyelitis in Dark Agouti rats and induces expansion of peripheral CD4+CD25+Foxp3+ regulatory T cells

Donia

Mangano

Amoroso

et al. 2009

Journal of Autoimmunity

View full text Add to dashboard Cite

“…The hypothesis that Treg cells could be involved in the pathogenesis of autoimmune diseases led to subsequent investigations not only in animal models with autoimmune disorders, but also in patients with such diseases in order to clarify the degree to which the Treg cells might be functionally impaired [6,7].…”

Section: Introductionmentioning

confidence: 99%

Role of regulatory T cells in rheumatoid arthritis: facts and hypothesis

Alunno

Bartoloni

Nocentini

et al. 2010

Autoimmun Highlights

View full text Add to dashboard Cite

Regulatory T cells (Treg) are a CD4 + lymphocyte subset involved in self-tolerance and autoimmunity prevention. There is evidence for a phenotypic and/or functional impairment of this cell subset during the natural history of several chronic autoimmune/inflammatory diseases, including rheumatoid arthritis (RA). Although the intracellular transcription factor FoxP3 is thought to be the master regulator of Treg cell function, a number of other molecules expressed on the cell surface have been proposed for the identification of Treg cells. This is important in order to favour their possible selective isolation and in the development of new therapeutic strategies. In the present paper, available data on phenotypic and functional characterization of Treg cells in both peripheral blood and synovial fluid from RA patients are reviewed and their possible pathogenic role in triggering and perpetuating rheumatoid joint inflammation is discussed.

show abstract

“…e immune system is thus immature and disordered and the incidence of allergic disease is increased [1]. One of the immunological characteristics of asthma is a 1/ 2 imbalance [2]. e quantity and activity of 1 cells are decreased, and those of 2 cells are increased.…”

mentioning

confidence: 99%

The effect of Lactobacillus johnsonii Ncc533 (La1) on the balance of Th1/Th2 cells in BALB/c mice

Yang

Li²,

Sun³

et al. 2011

CIM

View full text Add to dashboard Cite

e e ect of Lactobacillus johnsonii Ncc533 (La1) on the balance of 1/ 2 cells in BALB/c mice Abstract Purpose: To determine the e ect of Lactobacillus johnsonii Ncc533 (La1) on 1/ 2 balance, the production of IL-4 and IFN-γ by splenocytes was evaluated following its administration to mice from newborn to adult. Changes in IL-4 and IFN-γ expression and serum levels of OVA-speci c-IgE were then investigated in an asthma model. Methods:Using ow cytometry (FCM) and ELISA, the percentage of IL-4 and IFN-γ expressing splenocytes and serum levels of OVA-speci c-IgE were measured in di erent groups of mice.Results: e percentages of IL-4 and IFN-γ expressing splenocytes in the o spring and in the adults of the La1-treated group were not signi cantly di erent when compared with the water-treated group. In the asthma model, the percentages of IL-4 expressing cells and the serum levels of OVA-speci c-IgE in the La1-treated and water-treated group were signi cantly increased compared with those in the control group. e percentage of IFN-γ expressing cells was signi cantly lower in the La1-treated and water-treated groups. e percentage of IL-4 expressing cells and the serum levels of OVA-speci c-IgE in the La1-treated group were signi cantly lower compared with those in the water-treated group, whereas the percentage of IFN-γ expressing cells was signi cantly higher.Conclusion: Administration of La1 had no e ect on the immune system from the neonate to the adult in the normal mice. It did, however, signi cantly alter the percentages of IL-4 or IFN-γ expressing CD4 + T lymphocytes in the asthma model, suggesting that administration of La1 might regulate the immune response.ORIGINAL RESEARCH

show abstract

Role for suppressor T cells in the pathogenesis of autoimmune diseases (including rheumatoid arthritis). Facts and hypotheses

Cited by 15 publications

References 50 publications

Treatment with rapamycin ameliorates clinical and histological signs of protracted relapsing experimental allergic encephalomyelitis in Dark Agouti rats and induces expansion of peripheral CD4+CD25+Foxp3+ regulatory T cells

Treatment with rapamycin ameliorates clinical and histological signs of protracted relapsing experimental allergic encephalomyelitis in Dark Agouti rats and induces expansion of peripheral CD4+CD25+Foxp3+ regulatory T cells

Role of regulatory T cells in rheumatoid arthritis: facts and hypothesis

The effect of Lactobacillus johnsonii Ncc533 (La1) on the balance of Th1/Th2 cells in BALB/c mice

Contact Info

Product

Resources

About