Role of 18F-FDG PET in the diagnosis of Rasmussen's disease

Ochoa-Figueroa, M.A.; Cárdenas-Negro, C.; Allende-Riera, A.; Martínez-Gimeno, E.; DeSequera-Rahola, M.; Uña-Gorospe, J.

doi:10.1016/j.remnie.2011.10.001

Cited by 1 publication

(3 citation statements)

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“…If the lateralization of seizure onset is still in question after obtaining brain MRI and EEG, then PET, ictal SPECT (SISCOM), and/or MEG/MSI may play a role in lateralizing seizure onset. Bilateral PET hypometabolism has been associated with a relatively higher rate of seizure recurrence after HDS, while unilateral hemispheric hypometabolism on PET bolsters the argument to proceed with hemispherotomy and generally is associated with excellent rates of postoperative seizure freedom (la Fougere et al, 2009;Ochoa-Figueroa et al, 2012;Traub-Weidinger et al, 2016). Ictal SPECT is often performed in centers which have these capabilities, either for questionable cases or candidates for repeat hemispherotomy to identify residual areas of cortex which continue to cause seizures (Honda et al, 2013;Taussig et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Section: Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography ...mentioning

confidence: 99%

“…Evidence of diffuse hypometabolism of one hemisphere on PET may further bolster the argument to offer a patient HDS while bilateral hypometabolism may serve as a negative prognostic factor (Schur et al, 2018). In cases of Rasmussen's syndrome with subtle MRI findings, PET may play a role in seizure lateralization (Chugani et al, 1993;Ochoa-Figueroa et al, 2012). PET may also help to demonstrate a more focal area of hypometabolism, obviating the need for a more extensive disconnection, which may be especially helpful in infants in whom focal abnormalities may result in generalized EEG patterns (Halac et al, 2017).…”

Section: Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography mentioning

confidence: 99%

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An algorithmic approach to preoperative studies and patient selection for hemispheric disconnection surgery: a literature review

Tomycz¹,

Hale

Abdulrazeq

et al. 2020

Epileptic Disorders

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Hemispheric disconnection surgery (HDS) is one of the most effective surgical options for appropriate candidates with medicallyrefractory epilepsy (MRE) in whom most or all seizures arise from diffuse areas within a single hemisphere. While there are several well-accepted indications for HDS, there are additional patients who may benefit from HDS. However, there are no standardized recommendations for how preoperative studies should be used to identify appropriate candidates for HDS. We aimed to propose an algorithmic approach for presurgical evaluation in order to guide appropriate implementation of HDS for either cure or palliation of severe MRE in infants, children, and adults. Methods. We performed a qualitative review of the literature using PubMed, the Cochrane Library, and Google Scholar to select primary articles addressing imaging modalities used for the presurgical evaluation of patients with MRE being considered for HDS. Results. In total, we identified 126 articles that met our inclusion criteria. We propose a framework to guide candidate selection for HDS that incorporates various elements of the clinical presentation, electroencephalographic analysis, and neuroimaging. While this approach still requires prospective validation, the authors feel it is grounded in a synthesis of the best available evidence in the literature and informed by expert opinion. Conclusions. HDS is a powerful tool in the armamentarium of experienced multidisciplinary epilepsy centers to treat patients with severe MRE arising from diffuse areas constrained to a single hemisphere. The under-utilization of epilepsy surgery may be, in part, remedied by establishing evidence-based pathways for presurgical analyses to determine surgical candidacy.

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Section: Discussionmentioning

confidence: 99%

Section: Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography ...mentioning

confidence: 99%

Section: Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography mentioning

confidence: 99%

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An algorithmic approach to preoperative studies and patient selection for hemispheric disconnection surgery: a literature review

Tomycz¹,

Hale

Abdulrazeq

et al. 2020

Epileptic Disorders

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Role of 18F-FDG PET in the diagnosis of Rasmussen's disease

Cited by 1 publication

References 4 publications

An algorithmic approach to preoperative studies and patient selection for hemispheric disconnection surgery: a literature review

An algorithmic approach to preoperative studies and patient selection for hemispheric disconnection surgery: a literature review

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