Role of 3D Volumetric and Perfusion Imaging for Detecting Early Changes in Pancreatic Adenocarcinoma

Rahmanuddin, Syed; Korn, Ronald L.; Cridebring, Derek; Borazanci, Erkut; Brase, Jordyn; Boswell, William D.; Jamil, Asma; Cai, Wenli; Sabir, Aqsa; Motarjem, Pejman; Koay, Eugene J.; Mitra, Anirban P.; Goel, Ajay; Ho, J.; Chung, Vincent; Hoff, Daniel D. Von

doi:10.3389/fonc.2021.678617

Cited by 3 publications

(1 citation statement)

References 46 publications

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“…The Marley equation defined by Rahmanuddin et al (2021) describes the difference between arterial and venous perfusion to predict tumor aggressiveness (Figure 2A). The difference between the arterial phase (first 44 s after contrast injection) and the venous phase (up to 96 s after contrast injection) delineates pancreatic cancer, which is typically hyperintense in venous phase imaging.…”

Section: Marley Equationmentioning

confidence: 99%

Utilization of a novel 3D radiologic scoring method to define therapeutic response and surgical candidacy

Rahmanuddin¹,

Hoff²,

Chaudhry³

et al. 2023

Front. Imaging.

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PurposeNeoadjuvant therapy and surgical resection can improve the survival rate of patients who receive a diagnosis of pancreatic cancer and shows to be potentially curative. The aim of this study is to define a novel CT perfusion analytical method by observing the treatment response of pancreatic cancer patients in a neoadjuvant-treated population to determine surgical candidacy.Experimental designThis prospective study involved 22 adult patients with pancreatic ductal adenocarcinoma (PDAC). Participants received neoadjuvant therapy (paricalcitol, paclitaxel protein-bound, cisplatin, and gemcitabine) for up to 6 months. The study examined differences in density between the arterial and venous phases of CT scans using a mathematical analysis called the Marley equation. The data was used to assess treatment responses and determined whether a patient can become a surgical candidate. The consideration for surgical candidacy was defined by Dr. Rahmanuddin, termed the “R” score and graphically depicted as the “R” Clock. The R score determined the number of tumor-linked blood vessels. Any vessel associated with tumor involvement received a score of 1. Patients who received a score of 5 or less were eligible for surgery. 3D Tumor volumetric analyses were performed using GE AW 3D software to assess the treatment response associated with tumor perfusion.ResultsVisual differences in vascular involvement between baseline and final imaging were associated with a higher likelihood of proceeding to surgery. After administration of the neoadjuvant therapy, 81% of patients (18 of 22) received an R score of 5 or less, deeming all of them eligible for surgery. A total of 59% of patients (13 of 22) proceeded with the surgery. Changes in arterial and venous perfusion reflected tumor aggressiveness as defined by the Marley equation.ConclusionCT vessel perfusion using the R score and Marley Equation might be helpful in defining the surgical candidacy of PDAC patients when used in conjunction with 3D tumor volumetric quantification. The parameters defined by the R score determined higher perfusion scores as having greater vascular growth, and patients with tumor involvement of more than six vessels were deemed surgically unresectable. The Marley equation demonstrated tumor aggression via changes in arterial and venous perfusion. Additional studies are needed to further validate these methodologies and assess their clinical utility.

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Section: Marley Equationmentioning

confidence: 99%

Utilization of a novel 3D radiologic scoring method to define therapeutic response and surgical candidacy

Rahmanuddin¹,

Hoff²,

Chaudhry³

et al. 2023

Front. Imaging.

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nnU-Net-Based Pancreas Segmentation and Volume Measurement on CT Imaging in Patients with Pancreatic Cancer

Yang,

Kim,

Min

et al. 2024

Academic Radiology

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Applications of Polymers for Organ-on-Chip Technology in Urology

et al. 2022

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Organ-on-chips (OOCs) are microfluidic devices used for creating physiological organ biomimetic systems. OOC technology brings numerous advantages in the current landscape of preclinical models, capable of recapitulating the multicellular assemblage, tissue–tissue interaction, and replicating numerous human pathologies. Moreover, in cancer research, OOCs emulate the 3D hierarchical complexity of in vivo tumors and mimic the tumor microenvironment, being a practical cost-efficient solution for tumor-growth investigation and anticancer drug screening. OOCs are compact and easy-to-use microphysiological functional units that recapitulate the native function and the mechanical strain that the cells experience in the human bodies, allowing the development of a wide range of applications such as disease modeling or even the development of diagnostic devices. In this context, the current work aims to review the scientific literature in the field of microfluidic devices designed for urology applications in terms of OOC fabrication (principles of manufacture and materials used), development of kidney-on-chip models for drug-toxicity screening and kidney tumors modeling, bladder-on-chip models for urinary tract infections and bladder cancer modeling and prostate-on-chip models for prostate cancer modeling.

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Role of 3D Volumetric and Perfusion Imaging for Detecting Early Changes in Pancreatic Adenocarcinoma

Cited by 3 publications

References 46 publications

Utilization of a novel 3D radiologic scoring method to define therapeutic response and surgical candidacy

Utilization of a novel 3D radiologic scoring method to define therapeutic response and surgical candidacy

nnU-Net-Based Pancreas Segmentation and Volume Measurement on CT Imaging in Patients with Pancreatic Cancer

Applications of Polymers for Organ-on-Chip Technology in Urology

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