Role of active nanoliposomes in the surface and bulk mechanical properties of hybrid hydrogels

Kadri, R.; Bacharouch, J.; Elkhoury, Kamil; Messaoud, Ghazi Ben; Kahn, Cyril J.F.; Desobry, Stéphane; Linder, Michel; Tamayol, Ali; Francius, Grégory; Mano, João F.; Sánchez-González, Laura; Arab‐Tehrany, Elmira

doi:10.1016/j.mtbio.2020.100046

Cited by 23 publications

(15 citation statements)

References 45 publications

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“…Hydrogels are high water content materials and one of the few biomaterials that can be used to fabricate extracellular matrix (ECM) mimicking scaffolds [ 11 , 12 ]. Moreover, in addition to being highly biocompatible, hydrogels possess an advantageous physical and biological tunability, and desirable robustness in biofabrication [ [13] , [14] , [15] ].…”

Section: Introductionmentioning

confidence: 99%

Biofabrication of natural hydrogels for cardiac, neural, and bone Tissue engineering Applications

Elkhoury

Morsink²,

Sánchez-González³

et al. 2021

Bioactive Materials

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112

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Natural hydrogels are one of the most promising biomaterials for tissue engineering applications, due to their biocompatibility, biodegradability, and extracellular matrix mimicking ability. To surpass the limitations of conventional fabrication techniques and to recapitulate the complex architecture of native tissue structure, natural hydrogels are being constructed using novel biofabrication strategies, such as textile techniques and three-dimensional bioprinting. These innovative techniques play an enormous role in the development of advanced scaffolds for various tissue engineering applications. The progress, advantages, and shortcomings of the emerging biofabrication techniques are highlighted in this review. Additionally, the novel applications of biofabricated natural hydrogels in cardiac, neural, and bone tissue engineering are discussed as well.

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Section: Introductionmentioning

confidence: 99%

Biofabrication of natural hydrogels for cardiac, neural, and bone Tissue engineering Applications

Elkhoury

Morsink²,

Sánchez-González³

et al. 2021

Bioactive Materials

Self Cite

112

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“…Cytocompatible photoinitiators such as Irgacure 2959 or lithium phenyl‐2,4,6‐trimethylbenzoylphosphinate (LAP), among others, can be used to crosslink GelMA within seconds to few minutes. The stiffness and biomechanical properties of the resulting gel is dependent on the exposure time, the degree of substitution, addition of nanobiomaterials, and photoinitiator concentration, [ 196–198 ] to adapt them to the TME. For instance, with polymer concentrations ranging from 2.5% to 7% w/v, stiffness between 0.5 to 9.0 kPa can be achieved, without affecting hydrogels diffusional properties.…”

Section: Engineering the Tme Using Protein‐based Hydrogelsmentioning

confidence: 99%

Proteinaceous Hydrogels for Bioengineering Advanced 3D Tumor Models

et al. 2021

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The establishment of tumor microenvironment using biomimetic in vitro models that recapitulate key tumor hallmarks including the tumor supporting extracellular matrix (ECM) is in high demand for accelerating the discovery and preclinical validation of more effective anticancer therapeutics. To date, ECM‐mimetic hydrogels have been widely explored for 3D in vitro disease modeling owing to their bioactive properties that can be further adapted to the biochemical and biophysical properties of native tumors. Gathering on this momentum, herein the current landscape of intrinsically bioactive protein and peptide hydrogels that have been employed for 3D tumor modeling are discussed. Initially, the importance of recreating such microenvironment and the main considerations for generating ECM‐mimetic 3D hydrogel in vitro tumor models are showcased. A comprehensive discussion focusing protein, peptide, or hybrid ECM‐mimetic platforms employed for modeling cancer cells/stroma cross‐talk and for the preclinical evaluation of candidate anticancer therapies is also provided. Further development of tumor‐tunable, proteinaceous or peptide 3D microtesting platforms with microenvironment‐specific biophysical and biomolecular cues will contribute to better mimic the in vivo scenario, and improve the predictability of preclinical screening of generalized or personalized therapeutics.

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“…The inclusion of liposomes in the GelMA matrix in their study presented a sustained controlled release of the anticancer drug Gemcitabine for 4 days, whereas the free drug was released from a pure GelMA hydrogel in only 6 h. The loaded liposome-GelMA hydrogel killed MG63 cells in vitro and inhibited osteosarcoma in vivo, presenting itself as a promising implant for the treatment of osteosarcoma. In the field of wound healing, Kadri et al, reported that the nanofunctionalization of IPN GelMA-alginate hydrogels with rapeseed-derived liposomes significantly improved their mechanical properties and induced keratinocyte growth [ 104 ]. In another study, Yu et al, developed a liposome-GelMA hydrogel delivery system that controlled the release of the pro-healing chemokine stromal cell derived factor-1α, which might be used for clinical wound healing applications [ 103 ].…”

Section: Nanovesicles-hydrogels Interactionsmentioning

confidence: 99%

Engineering Smart Targeting Nanovesicles and Their Combination with Hydrogels for Controlled Drug Delivery

et al. 2020

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Smart engineered and naturally derived nanovesicles, capable of targeting specific tissues and cells and delivering bioactive molecules and drugs into them, are becoming important drug delivery systems. Liposomes stand out among different types of self-assembled nanovesicles, because of their amphiphilicity and non-toxic nature. By modifying their surfaces, liposomes can become stimulus-responsive, releasing their cargo on demand. Recently, the recognized role of exosomes in cell-cell communication and their ability to diffuse through tissues to find target cells have led to an increase in their usage as smart delivery systems. Moreover, engineering “smarter” delivery systems can be done by creating hybrid exosome-liposome nanocarriers via membrane fusion. These systems can be loaded in naturally derived hydrogels to achieve sustained and controlled drug delivery. Here, the focus is on evaluating the smart behavior of liposomes and exosomes, the fabrication of hybrid exosome-liposome nanovesicles, and the controlled delivery and routes of administration of a hydrogel matrix for drug delivery systems.

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Role of active nanoliposomes in the surface and bulk mechanical properties of hybrid hydrogels

Cited by 23 publications

References 45 publications

Biofabrication of natural hydrogels for cardiac, neural, and bone Tissue engineering Applications

Biofabrication of natural hydrogels for cardiac, neural, and bone Tissue engineering Applications

Proteinaceous Hydrogels for Bioengineering Advanced 3D Tumor Models

Engineering Smart Targeting Nanovesicles and Their Combination with Hydrogels for Controlled Drug Delivery

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