Role of adipokines FGF21, leptin and adiponectin in self-concept of youths with obesity

Li, Ge; Feng, Dan; Qu, Xingmin; Fu, Junsheng; Wang, Yonghui; Li, Lianxia; Li, Lujiao; Han, Lanwen; Esangbedo, Issy C.; Li, Mingyao; Li, Ming; Gao, Shan

doi:10.1016/j.euroneuro.2018.05.015

Cited by 13 publications

(9 citation statements)

References 33 publications

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“…The interassay CVs were <7.0%, <9.3% and <8.5%, respectively. FGF21 and RBP4 were measured using a commercial ELISA Kit (R&D Systems, Minnesota, USA) with interassay CVs of <7.4% and <10%, respectively 28 29. All samples were analyzed in duplicate.…”

Section: Methodsmentioning

confidence: 99%

Insulin resistance, beta-cell function, adipokine profiles and cardiometabolic risk factors among Chinese youth with isolated impaired fasting glucose versus impaired glucose tolerance: the BCAMS study

Feng

Esangbedo

et al. 2020

BMJ Open Diab Res Care

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ObjectiveImpaired fasting glucose (IFG) and impaired glucose tolerance (IGT) may convey disparate risks of metabolic consequences. Fasting plasma glucose (FPG), while an expedient screening procedure, may not adequately assess metabolic risk, particularly among youths. In order to inform a strategy for screening Chinese youth for pre-diabetes, we examined the relative value of IFG versus IGT to define metabolic risk by assessing their association with insulin resistance, beta-cell dysfunction, adverse adipokine profiles and other cardiometabolic risk factors.Research design and methodsWe recruited 542 subjects (age 14–28 years) from the Beijing Child and Adolescent Metabolic Syndrome study for an in-depth assessment of cardiometabolic risk factors, including a 2-hour oral glucose tolerance test, liver ultrasound and serum levels of four adipokines.ResultsFPG failed to identify nearly all (32/33) youths with IGT, whereas 2-hour plasma glucose (2 h PG) missed 80.8% (21/26) of subjects with IFG. Impaired beta-cell function was evident from decreased oral disposition indices in those with isolated impaired fasting glucose (iIFG) or isolated impaired glucose tolerance (iIGT) versus normal glucose tolerance (NGT) (all p<0.001), whereas reduced insulin sensitivity (Matsuda) index was most pronounced in the iIGT group (p<0.01). Moreover, alterations in adipokine levels (fibroblast growth factor 21, adiponectin and leptin/adiponectin ratio) were associated with iIGT (p<0.05) but not iIFG. Youths with iIGT had a 2-fold to 32-fold increased incidence of hypertriglyceridemia, hypertension and metabolic syndrome (MetS) compared with those with NGT. In addition, subgroup analyses of participants with normal FPG revealed that the odds of having IGT increased 3-fold to 18-fold among those with elevated TGs, hypertension, moderate-to-severe non-alcoholic fatty liver disease or MetS.ConclusionsChinese youth with iIGT exhibit a higher cardiometabolic risk profile than those with iIFG. Thus, 2 h PG is preferred over FPG to identify the pre-diabetes phenotype at greatest risk of subsequent development of cardiovascular disease.Trial registration numberNCT03421444.

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Section: Methodsmentioning

confidence: 99%

Insulin resistance, beta-cell function, adipokine profiles and cardiometabolic risk factors among Chinese youth with isolated impaired fasting glucose versus impaired glucose tolerance: the BCAMS study

Feng

Esangbedo

et al. 2020

BMJ Open Diab Res Care

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“…We selected the general ASC subscale from the Self-description Questionnaire II, developed by Marsh (1990b) and revised by Chinese scholars ( Chen and Cui, 1997 ). The revised Chinese version has acceptable reliability and validity and has been applied in related psychological research areas ( Chen et al, 1997 ; Xu et al, 2008 ; Chen and Shi, 2016 ).…”

Section: Methodsmentioning

confidence: 99%

Social Comparison Orientation and Social Adaptation Among Young Chinese Adolescents: The Mediating Role of Academic Self-Concept

et al. 2018

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This study aimed to investigate the relationship among social comparison orientation, academic self-concept (ASC), and social adaptation. A total of 1658 Chinese adolescents (48.88% male; aged 14–18 years, Mage = 16.01 ± 0.86 years) voluntarily participated in this study and completed questionnaires. Structural equation modeling (SEM) was performed to test the theory-driven model. The results showed that the relationship between comparison of opinion and social adaptation was mediated by ASC but that ASC did not play a mediating role between comparison of ability and social adaptation. These findings indicated that ASC could be one mechanism explaining the link between adolescents’ social comparison orientation and social adaptation. Furthermore, it is possible to intervene in their social comparison orientation and ASC to improve adolescents’ social adaptation.

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“…Adiponectin is a specific secretory adipokine that regulates of fatty acid oxidation (FAO), inhibits the accumulation of FFAs, maintains the glucose homeostasis throughout the body, and the sensitivity to hepatic insulin. Hypoadiponectinemia affects the metabolism of fatty acids and promotes a chronic state of inflammation in the liver [90]. On the other hand, leptin can impel the hepatic stellate cell activation and liver fibrosis, control the energy balance, and suppress appetite [91].…”

Section: Adipokinesmentioning

confidence: 99%

The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)

Tănase

Gosav

Costea

et al. 2020

Journal of Diabetes Research

320

180

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Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence and incidence. Epidemiological studies noted that T2DM patients have by two-fold increase to develop NAFLD, and vice versa. This complex and intricate association is supported and mediated by insulin resistance (IR). In this review, we discuss the NAFLD immunopathogenesis, connection with IR and T2DM, the role of screening and noninvasive tools, and mostly the impact of the current antidiabetic drugs on steatosis liver and new potential therapeutic targets.

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Role of adipokines FGF21, leptin and adiponectin in self-concept of youths with obesity

Cited by 13 publications

References 33 publications

Insulin resistance, beta-cell function, adipokine profiles and cardiometabolic risk factors among Chinese youth with isolated impaired fasting glucose versus impaired glucose tolerance: the BCAMS study

Insulin resistance, beta-cell function, adipokine profiles and cardiometabolic risk factors among Chinese youth with isolated impaired fasting glucose versus impaired glucose tolerance: the BCAMS study

Social Comparison Orientation and Social Adaptation Among Young Chinese Adolescents: The Mediating Role of Academic Self-Concept

The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)

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