Role of adipokines in the ovarian function: Oogenesis and steroidogenesis

Nikanfar, Saba; Oghbaei, Hajar; Rezaei, Yeganeh Rastgar; Zarezadeh, Reza; Jafari-Gharabaghlou, Davoud; Nejabati, Hamid Reza; Bahrami, Zahra; Bleisinger, Nathalie; Samadi, Nasser; Fattahi, Amir; Nouri, Mohammad; Dittrich, Ralf

doi:10.1016/j.jsbmb.2021.105852

Cited by 21 publications

(11 citation statements)

References 197 publications

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“…Adipose tissue, in addition to its well-known effects on whole-body energy regulation, is an important endocrine organ whose altered distribution and/or dysfunction could lead to inflammation, oxidative stress, and/or lipotoxicity, all being associated with insulin resistance. Adipokines produced by adipose tissue also display important regulatory roles on the reproductive axis [21]. Defects in adipocyte differentiation and/or functions are the main determinants of lipodystrophy syndromes, associated with insulin resistance and PCOS features [10,11,[14][15][16][17][19][20][21][22][23][24].…”

Section: Dysfunctional Adiposity As a Driver Of Insulin Resistance An...mentioning

confidence: 99%

“…Adipokines produced by adipose tissue also display important regulatory roles on the reproductive axis [21]. Defects in adipocyte differentiation and/or functions are the main determinants of lipodystrophy syndromes, associated with insulin resistance and PCOS features [10,11,[14][15][16][17][19][20][21][22][23][24]. Leptin deficiency due to lipoatrophy contributes to insulin resistance, as shown by the metabolic benefit of substitutive therapy with the leptin analog metreleptin in generalized lipoatrophy [22].…”

Section: Dysfunctional Adiposity As a Driver Of Insulin Resistance An...mentioning

confidence: 99%

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Role of insulin resistance on fertility – Focus on polycystic ovary syndrome

Vatier

Christin-Maître

Vigouroux

2022

Annales d'Endocrinologie

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Section: Dysfunctional Adiposity As a Driver Of Insulin Resistance An...mentioning

confidence: 99%

Section: Dysfunctional Adiposity As a Driver Of Insulin Resistance An...mentioning

confidence: 99%

Role of insulin resistance on fertility – Focus on polycystic ovary syndrome

Vatier

Christin-Maître

Vigouroux

2022

Annales d'Endocrinologie

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“…However, there is no consensus regarding the effects of adipokines on hormones which can be due to different reasons such as species differences, the dose of adipokines ( 13 , 14 ), size and stage of ovarian follicles ( 15 ), and phase of the menstrual cycle ( 16 ). The association of adipokines with steroidogenesis and hormones has previously been reviewed in depth by our group ( 17 ). Interestingly, adipokines can be under the regulation of hormones.…”

Section: Adipokines In Embryo Implantationmentioning

confidence: 99%

Role of adipokines in embryo implantation

Jafari-Gharabaghlou

Vaghari‐Tabari

Oghbaei

et al. 2021

Endocrine Connections

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Embryo implantation is a complex process in which multiple molecules acting together under strict regulation. Studies showed the production of various adipokines and their receptors in the embryo and uterus, where they can influence the maternal-fetal transmission of metabolites and embryo implantation. Therefore, these cytokines have opened a novel area of study in the field of embryo-maternal cross-talk during early pregnancy. In this respect, the involvement of adipokines has been widely reported in the regulation of both physiological and pathological aspects of the implantation process. However, the information about the role of some recently identified adipokines is limited. This review aims to highlight the role of various adipokines in embryo-maternal interactions, endometrial receptivity, and embryo implantation, as well as the underlying molecular mechanisms.

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“…Adiponectin deficiency may cause impaired follicular development, disturbed ovarian steroidogenesis, and the development of ovarian-related disorders, including polycystic ovary syndrome (PCOS) [ 10 ]. The expression of AdipoR1 and AdipoR2 has been reported in mammalian ovarian somatic cells and follicles, suggesting that adiponectin may directly act on the ovary to regulate follicle development and steroidogenesis [ 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Seasonal Change in Adiponectin Associated with Ovarian Morphology and Function in Wild Ground Squirrels (Citellus dauricus Brandt)

Fan

Zhang

et al. 2022

IJMS

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The goal of this study is to explore the relationship between altered circulating adiponectin concentration, ovarian tissue morphology, ovarian steroidogenesis, and sex hormone production in ovaries of wild ground squirrels. The ovarian mass differed significantly during the breeding and non-breeding seasons, and the circulating estradiol and progesterone concentrations were significantly higher in the breeding season, while the circulating adiponectin level was significantly lower. The expression levels of gonadotropin receptors (FSHR and LHR) and steroidogenic enzymes (StAR, P450scc, P450arom, and 3β-HSD) were significantly higher during the breeding season. Comparing the ovarian transcriptome data of wild ground squirrels between the two periods, we found that some differentially expressed genes were enriched for ovarian steroidogenesis and the adipocytokine signaling pathway, which correlated with our present results. Notably, the MAPK signaling pathway was also enriched and its related genes (Erk1, p38 Mapk, Jnk) were up-regulated by qPCR during the non-breeding season. These findings suggested that adiponectin may be involved in the regulation of seasonal changes in the ovarian function of wild ground squirrels, possibly by acting on the MAPK signaling pathway to regulate sex steroidogenesis in the ovaries.

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Role of adipokines in the ovarian function: Oogenesis and steroidogenesis

Cited by 21 publications

References 197 publications

Role of insulin resistance on fertility – Focus on polycystic ovary syndrome

Role of insulin resistance on fertility – Focus on polycystic ovary syndrome

Role of adipokines in embryo implantation

Seasonal Change in Adiponectin Associated with Ovarian Morphology and Function in Wild Ground Squirrels (Citellus dauricus Brandt)

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