Role of Adiponectin in Cervical Cancer

Abstract

Background: Cervical Cancer (CC) is the most common leading cancer in women globally. This is considered to be the type of cancer that is restricted to women. Any women in the reproductive age range can develop CC. However, women between the ages of 25 and 39 are at a higher risk. Objective: In comparison with developed countries, the screening and awareness of CC in developing countries are significantly low. Infection with Human papillomavirus (HPV) is the main cause of CC, especially HPV-16 and HPV-18. Other than HPV, there are other factors that can contribute to CC, such as Human simplex virus (HSV) infection and immunocompromised patients with HIV. Conclusion: Cervical cancer can be detected by molecular techniques such as (1) PCR, (2) visual acetic acid method, (3) DNA Hybrid II test, (4) liquid-based cytology, (5) Pap-Smear techniques, and (6) colposcopy techniques. Early detection of CC is very much needed; cryotherapy or LEEP (Loop electro surgical excision procedure) can be conducted during the pre-invasive stage of CC. Some metabolic changes in the human body such as fluctuating levels of insulin and triglycerides and increased activity of adiponectin may lead to CC. These contributing factors, such as adipokines, can be used as biomarkers for CC detection.

Adiponectin inhibits the activation of lung fibroblasts and pulmonary fibrosis by regulating the nuclear factor kappa B (NF-κB) pathway

“…As a hormone, its main function is to regulate metabolism and maintain the body’s energy homeostasis [ 6 ]. Over the past two decades, the critical roles of APN in preventing a wide variety of diseases have been identified, such as diabetes [ 7 ], obesity, Alzheimer’s disease [ 8 ], chronic kidney disease [ 9 ], rheumatoid arthritis [ 10 ], and cancer [ 11 , 12 ]. It exerts strong protective roles in target organs, including kidney, brain, heart, skeleton, and lung, against cell apoptosis and inflammation induced by various stimulations [ 13 ].…”