Role of Adiponectin in Patients With Non-Insulin Dependent Diabetes Mellitus

El-Nuweihy, A. M.; El-Melegy, Nagla T; Ameen, Noorul; Radwan, Eman

doi:10.21608/bfsa.2010.64723

Cited by 2 publications

(3 citation statements)

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“…Our results have also shown that there was a gender difference in the correlation between serum leptin and BMI in male and female participants as in table (5). Previous studies have shown gender differences in adipokines concentrations (15,16) .…”

Section: Discussionsupporting

confidence: 79%

“…It does not only respond to afferent signals from traditional hormone systems and the central nervous system but also expresses and secretes factors with important endocrine functions. These factors include leptin, adiponectin, plasminogen activator inhibitor-1, proteins of the renin-angiotensin system, acylation stimulating protein and resistin (5) . Leptin, (from the Greek word leptos, meaning thin) is a peptide hormone, secreted from adipose tissue, which influences energy homeostasis, immune and neuroendocrine function (6) .In humans, it is well established that plasma leptin levels are directly proportional to percentage body fat.…”

Section: Introductionmentioning

confidence: 99%

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Study the levels of Leptin, and Adiponectin with Paraoxonase in Obese Individuals (male & female)

Sarhat¹

2023

Tikrit J. Pure Sci.

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Obesity is a well-known risk factor of metabolic complications and cardiovascular disease. Associations between anthropometric measurements and fat distribution and risk factors for cardiovascular disease have been demonstrated in several populations. To study the association of various measures of body mass index (BMI), waist circumference (WC), percentage of body fat (%BF), with leptin, Adiponectin, and paraoxonase. To study the association between leptin , adiponectin with Paraoxonase. This study conducted from of February 2013 until March 2014, all individuals were randomly recruited from Kirkuk and Tikrit Governorate .Hormonal assay of leptin, adiponectin, Paraoxonase, and glucose. Blood samples collected from 220 individuals, and these samples were divided into three groups according to BMI. Group 1 (Normal Weight group n=80), Group 2 (Over Weight group, n=58), Group 3 (Obese group, n=62) . The statistical analysis (students t-test) exhibited significant (P≥ 0.0001)elevation for leptin , paraoxonase, and glucose, while significant decrease in adiponectin in over weight and obese groups compared with normal weight groups. The correlation coefficient (r) between Leptin and other parameters were calculated with regression plot showed a negative correlation with adiponectin, and paraoxonase in over weight and obese group. There was a positive correlation between adiponectin with paraoxonase, but a negative correlation with leptin, in over weight and obese group. Conclusion: Adiponectin as hormone play an important role in the prevention of hyperlipidemia, and consequently atherosclerosis and its complications while Leptin act as atherosclerotic factors. The results indicated that adiponectin positively associated with paraoxonase while Leptin negatively correlated with paraoxonase.

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Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Study the levels of Leptin, and Adiponectin with Paraoxonase in Obese Individuals (male & female)

Sarhat¹

2023

Tikrit J. Pure Sci.

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“…17 Contrary to our findings, several human studies have confirmed that obesity, insulin resistance and type 2 diabetes are associated with lower levels of adiponectin compared to normal healthy individuals, though the effects of drug therapy on adiponectin levels of these patients were not considered. [18][19][20] Type 2 diabetics studied had significantly (p<0.05) higher BMI, WC, fasting plasma glucose and HbA1c values than non-diabetics. Diabetes is a common endocrine disorder characterized by hyperglycemia leading to non-enzymatic glycation of proteins, responsible for chronic complications.…”

Section: Discussionmentioning

confidence: 99%

Adiponectin and cardiovascular risk factors in relation with glycemic control in type 2 diabetics

et al. 2013

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Background: Adiponectin has been associated with insulin resistance and dyslipidemia in Type 2 diabetes, though the mechanism of association is still uncertain. The adiponectin levels and lipid profile in relation to glycemic control were investigated in type 2 diabetics. Methods: Forty two diabetic subjects (35-64 years) and 33 age-matched non-diabetic subjects were recruited into this case control study. Socio-demographic characteristics, anthropometric indices and blood pressure were obtained. Total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein, (HDL), fasting plasma glucose (FPG), and glycated hemoglobin (HbA1c) were estimated using colorimetric methods, atherogenic index (AI) was calculated, while serum adiponectin was determined by ELISA method. Results: Adiponectin levels of type 2 diabetics were not significantly different from the non-diabetics studied (p>0.05). Higher TG levels were observed in diabetics with poor glycemic control compared with those with good glycemic control (p<0.05). Hypertensive diabetics have higher TC and lower HDL-C levels compared with non hypertensive diabetics (p<0.05). Adiponectin correlated positively with HDL-C (r = 0.739, p = 0.01) and negatively with AI (r = -0.539, p = 0.001) only in the non diabetic group. No significant differences were observed in the adiponectin levels in relation with gender, duration of diabetes and glycemic state (p>0.05). Conclusion: Type 2 diabetics do not have lower adiponectin levels. Gender, duration of diabetes and glycemic control does not seem to exert any influence on adiponectin levels in type 2 diabetes. Adiponectin may be associated with reduced risk of atherosclerosis through its effects on HDL cholesterol metabolism. [Int J Res Med Sci 2013; 1(4.000): 563-570

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Role of Adiponectin in Patients With Non-Insulin Dependent Diabetes Mellitus

Abstract: A. M. El-Nuweihy, et al. 108LDL, insulin and c-peptide. The ability of adiponectin to increase insulin sensitivity in conjunction with its anti-inflammatory and anti-atherogenic properties have made this novel adipocytokine a promising therapeutic tool for the future.

Cited by 2 publications

References 40 publications

Study the levels of Leptin, and Adiponectin with Paraoxonase in Obese Individuals (male & female)

Study the levels of Leptin, and Adiponectin with Paraoxonase in Obese Individuals (male & female)

Adiponectin and cardiovascular risk factors in relation with glycemic control in type 2 diabetics

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