Role of adrenoceptor subtypes in memory consolidation

Gibbs, Marie E.; Summers, Roger J.

doi:10.1016/s0301-0082(02)00023-0

Cited by 166 publications

(164 citation statements)

References 197 publications

Supporting

Mentioning

151

Contrasting

Unclassified

Order By: Relevance

“…We have also found this multimodal brain region to be important in the formation of memory in both passive avoidance and bead discrimination learning paradigms (Gibbs and Ng, 1977;Gibbs and Summers, 2002a). Memory formation is energy dependent and central injection of glucose can modulate memory (Ragozzini et al, 1998;Krebs and Parent, 2005;McNay et al, 2000McNay et al, , 2001.…”

Section: Introductionmentioning

confidence: 70%

“…The experimental conditions are described in detail elsewhere (Gibbs and Summers, 2002a). Briefly chicks are placed in pairs on arrival at the laboratory, each chick differentiated by their natural color variation (a dark and a light chick for each pair).…”

Section: Animals and Housingmentioning

confidence: 99%

“…The process of memory formation proceeds in a series of physiological and biochemical steps from the point of input and acquisition of learning to the stage when reinforcement processes determine whether the memory will be retained (McGaugh, 2000;Gibbs and Summers, 2002a). After the initial learning experience, short-term or labile memory is consolidated into permanent memory by endogenous processes, such as arousal arising from the experience (McGaugh, 2000).…”

Section: Introductionmentioning

confidence: 99%

“…When the learning trial is constrained to a single discrete event, individual reinforcement steps can be identified and the processes followed until the memory becomes relatively permanent Gibbs and Summers, 2002a;Izquierdo et al, 2006). In young chicks, a single-trial bead discrimination task allows dissection of memory into stages that are revealed by testing separate chicks at different times after training or by pharmacological intervention (Gibbs and Ng, 1977;Gibbs and Summers, 2002a).…”

Section: Introductionmentioning

confidence: 99%

“…In young chicks, a single-trial bead discrimination task allows dissection of memory into stages that are revealed by testing separate chicks at different times after training or by pharmacological intervention (Gibbs and Ng, 1977;Gibbs and Summers, 2002a). Chicks are precocial animals and soon after hatch have to function and learn about their environment for survival.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Role of β-Adrenoceptors in Memory Consolidation: β3-Adrenoceptors Act on Glucose Uptake and β2-Adrenoceptors on Glycogenolysis

Gibbs

Hutchinson

Summers

2007

Neuropsychopharmacol

Self Cite

View full text Add to dashboard Cite

Noradrenaline, acting via b 2 -and b 3 -adrenoceptors (AR), enhances memory formation in single trial-discriminated avoidance learning in day-old chicks by mechanisms involving changes in metabolism of glucose and/or glycogen. Earlier studies of memory consolidation in chicks implicated b 3 -rather than b 2 -ARs in enhancement of memory consolidation by glucose, but did not elucidate whether stimulation of glucose uptake or of glycolysis was responsible. This study examines the role of glucose transport in memory formation using central injection of the nonselective facilitative glucose transporter (GLUT) inhibitor cytochalasin B, the endothelial/astrocytic GLUT-1 inhibitor phloretin and the Na + /energy-dependent endothelial glucose transporter (SGLT) inhibitor phlorizin. Cytochalasin B inhibited memory when injected into the mesopallium (avian cortex) either close to or between 25 and 45 min after training, whereas phloretin and phlorizin only inhibited memory at 30 min. This suggested that astrocytic/endothelial (GLUT-1) transport is critical at the time of consolidation, whereas a different transporter, probably the neuronal glucose transporter (GLUT-3), is important at the time of training. Inhibition of glucose transport by cytochalasin B, phloretin, or phlorizin also interfered with b 3 -AR-mediated memory enhancement 20 min posttraining, whereas inhibition of glycogenolysis interfered with b 2 -AR agonist enhancement of memory. We conclude that in astrocytes (1) activities of both GLUT-1 and SGLT are essential for memory consolidation 30 min posttraining; (2) neuronal GLUT-3 is essential at the time of training; and (3) b 2 -and b 3 -ARs consolidate memory by different mechanisms; b 3 -ARs stimulate central glucose transport, whereas b 2 -ARs stimulate central glycogenolysis.

show abstract

Section: Introductionmentioning

confidence: 70%

Section: Animals and Housingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Role of β-Adrenoceptors in Memory Consolidation: β3-Adrenoceptors Act on Glucose Uptake and β2-Adrenoceptors on Glycogenolysis

Gibbs

Hutchinson

Summers

2007

Neuropsychopharmacol

Self Cite

View full text Add to dashboard Cite

show abstract

β1‐adrenergic receptor activation enhances memory in Alzheimer's disease model

Coutellier

Ardestani

Shamloo

2014

Ann Clin Transl Neurol

View full text Add to dashboard Cite

Objective Deficits in social recognition and learning of social cues are major symptoms of neurodegenerative disorders such as Alzheimer’s disease (AD). Here we studied the role of β1-noradrenergic signaling in cognitive function to determine whether it could be used as a potential therapeutic target for AD. Methods Using pharmacological, biochemical and behavioral tools, we assessed social recognition and the β1-adrenergic receptor (ADR) and its downstream PKA/phospho-CREB (pCREB) signaling cascade in the medial amygdala (MeA) in Thy1-hAPPLond/Swe+(APP) mouse model of AD. Results Our results demonstrated that APP mice display a significant social recognition deficit which is dependent on the β1-adrenergic system. Moreover, betaxolol, a selective β1-ADR antagonist, impaired social but not object/odor learning in C57Bl/6 mice. Our results identifies activation of the PKA/pCREB downstream of β1-ADR in MeA as responsible signaling cascade for learning of social cues in MeA. Finally, we found that xamoterol, a selective β1-ADR partial agonist, rescued the social recognition deficit of APP mice by increasing nuclear pCREB. Interpretation Our data indicate that activation of β1-ADR in MeA is essential for learning of social cues, and that an impairment of this cascade in AD may contribute to pathogenesis and cognitive deficits. Therefore, selective activation of β1-ADR may be used as a therapeutic approach to rescue memory deficits in AD. Further safety and translational studies will be needed to ensure the safety of this approach.

show abstract

Lactate: A Novel Signaling Molecule in Synaptic Plasticity and Drug Addiction

Wan

Dong

et al. 2019

BioEssays

View full text Add to dashboard Cite

l‐Lactate is emerging as a crucial regulatory nexus for energy metabolism in the brain and signaling transduction in synaptic plasticity, memory processes, and drug addiction instead of being merely a waste by‐product of anaerobic glycolysis. In this review, the role of lactate in various memory processes, synapse plasticity and drug addiction on the basis of recent studies is summarized and discussed. To this end, three main parts are presented: first, lactate as an energy substrate in energy metabolism of the brain is described; second, lactate as a novel signaling molecule in synaptic plasticity, neural circuits, memory, and drug addiction is described; and third, in light of the above descriptions, it is plausible to speculate that lactate is predominantly a signaling molecule in specific memory processes and partly acts as an energy substrate. The future perspective in lactate signaling involving microglia and associated precise signaling pathways in the brain is highlighted.

show abstract

Role of adrenoceptor subtypes in memory consolidation

Cited by 166 publications

References 197 publications

Role of β-Adrenoceptors in Memory Consolidation: β3-Adrenoceptors Act on Glucose Uptake and β2-Adrenoceptors on Glycogenolysis

Role of β-Adrenoceptors in Memory Consolidation: β3-Adrenoceptors Act on Glucose Uptake and β2-Adrenoceptors on Glycogenolysis

β1‐adrenergic receptor activation enhances memory in Alzheimer's disease model

Lactate: A Novel Signaling Molecule in Synaptic Plasticity and Drug Addiction

Contact Info

Product

Resources

About