Role of adrenocorticotropic hormone in essential hypertension and primary aldosteronism

Armanini, Decio; Andrisani, Alessandra; Ambrosini, Guido; Bordin, Luciana; Sabbadin, Chiara

doi:10.1111/jch.12951

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…Consistent with the previous results, high CORT, ATCH, and NA concentrations reflect the hyperactive state of the HPA axis, which mediates neural and behavioral responses to stress and hypertension. 19,20…”

Section: Effects Of Cums On the Phonotypes Of Ratsmentioning

confidence: 99%

The mechanism of chronic unpredictable mild stress induced high blood pressure in rats: a proteomic and targeted metabolomic analysis

Zhao

et al. 2023

Mol. Omics

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Section: Effects Of Cums On the Phonotypes Of Ratsmentioning

confidence: 99%

The mechanism of chronic unpredictable mild stress induced high blood pressure in rats: a proteomic and targeted metabolomic analysis

Zhao

et al. 2023

Mol. Omics

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“…9 Adrenocorticotropic hormone has an important role in controlling the synthesis of mineralocorticoids, including aldosterone, as well as components of the renin-angiotensin-aldosterone system which is a frequently utilized target when medically managing hypertension. 9,28,29 Abiraterone also results in increased mineralocorticoid production. Abiraterone is given in conjunction with prednisone at a total daily dose of 5–10 mg/day to prevent toxicities related to mineralocorticoid excess, including hypertension and hypokalemia.…”

Section: Hypertensionmentioning

confidence: 99%

Hypertension and QT interval prolongation associated with targeted systemic cancer therapies

Fahey

Piccolo

Bergsbaken

et al. 2020

J Oncol Pharm Pract

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Objective To summarize the proposed mechanisms behind hypertension and QT interval prolongation associated with use of targeted systemic cancer therapies and provide recommendations for monitoring or managing these toxicities. Summary The cardiotoxic effects of targeted systemic cancer therapies represents a new paradigm of cancer treatment associated cardiovascular adverse events. National guidelines regarding optimal monitoring and management strategies for hypertension and QT interval prolongation associated with use of these therapies are lacking. While the pathophysiological drivers of hypertension due to targeted systemic cancer therapies differ by class of targeted therapy, general management strategies do not. Routine blood pressure monitoring throughout the duration of therapy is recommended for all agents. Patients who experience hypertension often can be treated with the addition or modification of antihypertensive therapies. Uncontrolled hypertension despite optimal medical management may require dose modifications or discontinuation of the targeted systemic cancer therapy. Electrocardiogram monitoring is recommended for patients who receive targeted therapies that may prolong the QT interval. Minimizing or managing drug interactions with other QT prolonging medications is recommended in addition to ensuring adequate electrolyte supplementation. Dose modifications or discontinuation of the targeted systemic therapy may be necessary for patients who experience QT interval prolongation. Conclusions Appropriate cardiovascular monitoring and timely management of treatment-emergent toxicities can optimize therapy for patients receiving targeted systemic cancer therapies associated with a risk of drug-induced hypertension or QT interval prolongation.

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“…Aldosterone is regulated not only by the RAAS, but also by the potassium concentration and acutely by ACTH . Aldosterone is interplaying with serum sodium and potassium levels, which are also regulated by osmolality and vasopressin.…”

Section: The Role Of Raas In Sodium Content Hypertension and Cardiomentioning

confidence: 99%

Relationship between water and salt intake, osmolality, vasopressin, and aldosterone in the regulation of blood pressure

Armanini

Bordin

Donà

et al. 2018

J of Clinical Hypertension

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Role of adrenocorticotropic hormone in essential hypertension and primary aldosteronism

Cited by 3 publications

References 21 publications

The mechanism of chronic unpredictable mild stress induced high blood pressure in rats: a proteomic and targeted metabolomic analysis

The mechanism of chronic unpredictable mild stress induced high blood pressure in rats: a proteomic and targeted metabolomic analysis

Hypertension and QT interval prolongation associated with targeted systemic cancer therapies

Relationship between water and salt intake, osmolality, vasopressin, and aldosterone in the regulation of blood pressure

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