Role of AFP mRNA expression in peripheral blood as a predictor for postsurgical recurrence of hepatocellular carcinoma: A systematic review and meta-analysis

Ding, Xiang; Yang, Lian-Yue; Huang, Gengwen; Yang, Jianqing; Liu, Heli; Wang, Wei; Peng, Jinwu; Yang, Jie-Quan; Tao, Yiming; Chang, Zhigang; Ling, Xiu-Shou

doi:10.3748/wjg.v11.i17.2656

Cited by 20 publications

(17 citation statements)

References 24 publications

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“…The recurrence-free interval of HCC patients with postoperative serum AFP mRNA positivity has been reported to be significantly shorter than that of HCC patients with postoperative negativity (53% vs 88% at 1 year, 37% vs 60% at 2 years, P = 0.014) [42] , and the recurrence-free survival rates of HCC patients with postoperative serum AFP mRNA positivity have been reported to be significantly lower than those of HCC patients with preoperative positivity (52.6% vs 81.8% at 1 year, 15.6% vs 54.5% at 2 years, and 0% vs 29.2% at 3 years, P < 0.001) [43] . From the result of meta-analysis, the expression of AFP mRNA one week after surgery has also been showed to be correlated with the recurrence of HCC [44] . Moreover, the simultaneous determination of AFP mRNA and melanoma antigen gene (MAGE-1) mRNA may have a higher sensitivity and specificity [41] .…”

Section: Genesmentioning

confidence: 99%

Serum tumor markers for detection of hepatocellular carcinoma

Zhou¹

2006

WJG

311

259

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Alpha-fetoprotein and alpha-fetoprotein-L3Alpha fetoprotein (AFP) is a fetal specific glycoprotein produced primarily by the fetal liver. Normally, its serum concentration falls rapidly after birth and its synthesis in adult life is repressed. However, greater than 70% of HCC patients have a high serum concentration of AFP because of the tumor excretion. Forty years after its discovery, serum AFP remains a most useful tumor marker in screening HCC patients. The serum concentration of 20 ng/mL is the most commonly used cut-off value to differentiate HCC patients from healthy adults in clinical researches. However, some investigations have showed that the cut-off value is fluctuant in different ethnic groups. REVIEW Serum tumor markers for detection of hepatocellular carcinoma AbstractHepatocellular carcinoma (HCC) is one of the most frequent malignant tumors and is the second most common cause of cancer death in China. Therefore, it is very important to detect this disease and the recurrence at its earlier period. Serum tumor markers, as the effective method for detecting hepatocellular carcinoma for a long time, could be divided into 4 categories: oncofetal antigens and glycoprotein antigens; enzymes and isoenzymes; genes; and cytokines. Serum alpha fetoprotein (AFP) is the most widely used tumor marker in detecting patients with hepatocellular carcinoma, and has been proven to have capability of prefiguring the prognosis. However, it has been indicated that AFP-L3 and DCP excel AFP in differentiating hepatocellular c a r c i n o m a f r o m n o n m a l i g n a n t h e p a t o p a t h y a n d detecting small hepatocellular carcinoma. Some tumor markers, such as human cervical cancer oncogene and human telomerase reverse transcriptase mRNA, have also been indicated to have higher accuracies than AFP. Furthermore, some other tumor markers, such as glypican-3, gamma-glutamyl transferase II, alpha-lfucosidase, transforming growth factor-beta1, tumorspecific growth factor, have been indicated to be available supplementaries to AFP in the detection. AFP mRNA has been shown to correlate with the metastasis and recurrence of HCC, and it may be the most useful marker to prefigure the prognosis. Some other markers, such as gamma-glutamyl transferase mRNA, vascular endothelial growth factor, and interleukin-8, could also be used as available prognostic indicators, and the simultaneous determination of AFP and these markers may detect the recurrence of HCC at its earlier period.

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Section: Genesmentioning

confidence: 99%

Serum tumor markers for detection of hepatocellular carcinoma

Zhou¹

2006

WJG

311

259

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“…According to some researchers (Ding et al, 2005), hyperthermia at 43 ℃ for 30 min can generally lead to cell death in sensitive tissues, while when the hyperthermia is as high as 46 ℃ or above, necrosis occurs. Additionally, different cancer cells had variant reactiveness towards high temperature.…”

Section: Discussionmentioning

confidence: 99%

Killing Effects of Different Physical Factors on Extracorporeal HepG2 Human Hepatoma Cells

Zhang

Zhou²,

Wang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…According to clinical experience, if a high level of AFP is found in the serum, the first thought is that the patient has HCC. If this appears after surgery or chemotherapy, it indicates a poor prognosis, such as recurrence or metastasis [22][23][24][25][26][27] . The ABC transporter for discharging Hoechst 33 342, which is called the breast cancer resistance protein, has a high efflux capacity with a wide substrate range, including mitoxantrone and methotrexate [28] .…”

Section: Discussionmentioning

confidence: 99%

Effect of Bcl-2 and Bax on survival of side population cells from hepatocellular carcinoma cells

Fan¹,

Ren²,

Zhang³

et al. 2007

WJG

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AIM:To understand the role and significance of side population (SP) cells from hepatocellular carcinoma (HCC) in hepatocarcinogenesis, development, relapse and metastasis, we simulated the denutrition conditions that cancer cells experience in clinical therapy, observed the different anti-apoptosis ability of SP cells and non-SP cells under such conditions, and established the possible effects of P53, Bcl-2 and Bax on survival of SP cells. METHODS:We used flow cytometry to analyze and sort the SP and non-SP cells in established HCC lines MHCC97 and hHCC. We evaluated cell proliferation by methyl thiazolyl tetrazolium (MTT) assay and investigated the expression of p53, bcl-2 and bax genes during denutrition, by RT-PCR and immunofluorescence staining. RESULTS:The percentage of SP cells in the two established HCC lines was 0.25% and 0.5%, respectively. SP cells had greater anti-apoptosis and proliferation ability than non-SP cells. Expression of Bcl-2 and Bax in SP and non-SP cells differed during denutrition. The former was up-regulated in SP cells, and the latter was up-regulated in non-SP cells. CONCLUSION:It may be that different upstream molecules acted and led to different expression levels of Bcl-2 and Bax in these two cell lines. There was a direct relationship between up-regulation of Bcl-2 and down-regulation of Bax and higher anti-apoptosis ability in SP cells. It may be that the existence and activity of SP cells are partly responsible for some of the clinical phenomena which are seen in HCC, such as relapse or metastasis. Further research on SP cells may have potential applications in the field of anticancer therapy.

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Role of AFP mRNA expression in peripheral blood as a predictor for postsurgical recurrence of hepatocellular carcinoma: A systematic review and meta-analysis

Abstract: AFP mRNA expression in peripheral blood 1 wk after surgery correlated with the recurrence of HCC and was a good predictor for tumor recurrence.

Cited by 20 publications

References 24 publications

Serum tumor markers for detection of hepatocellular carcinoma

Serum tumor markers for detection of hepatocellular carcinoma

Killing Effects of Different Physical Factors on Extracorporeal HepG2 Human Hepatoma Cells

Effect of Bcl-2 and Bax on survival of side population cells from hepatocellular carcinoma cells

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