Role of AMPA and NMDA receptors in the nucleus accumbens shell in turning behaviour of rats: interaction with dopamine receptors

Ikeda, Hiroko; Akiyama, Gaku; Fujii, Y.; Minowa, R; Koshikawa, Noriaki; Cools, Alexander R.

doi:10.1016/s0028-3908(02)00334-9

Cited by 27 publications

(22 citation statements)

References 33 publications

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“…These regions, reported to have NMDARs (Bernard and Bolam, 1998;Ikeda et al, 2003;Jarvis et al, 1987;Monaghan and Cotman, 1986;Pal et al, 1999;Petralia et al, 1994), included cerebral cortex, caudate-putamen, globus pallidus, hippocampus, substantia nigra, and nucleus accumbens. NMDA has also been reported to increase the regional cerebral metabolic rate for glucose, rCMR glc , a marker of axonal activity (Sokoloff, 1999), in the rat suprachiasmatic nucleus (Shibata et al, 1992), frontal cortex layers V-VI, globus pallidus, caudateputamen, substantia nigra, thalamus, nucleus accumbens, and lateral habenular nucleus (Browne et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

“…For example, dopaminergic and glutamatergic/NMDA transmission are closely linked in the mammalian brain, particularly in the prefrontal cortex, striatum, and nucleus accumbens (Ferretti et al, 2005;Ikeda et al, 2003;Piomelli and Di Marzo, 1993;Rogue et al, 1990;Takeuchi et al, 2002;Tseng and O'Donnell, 2004;Wang et al, 2003). Medium-sized spiny neurons, the majority of neurons in the neostriatum, receive convergent glutamate-containing afferents from the neocortex and dopamine-containing afferents from the substantia nigra and ventral tegmentum (Murata et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

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Chronic Lithium Chloride Administration Attenuates Brain NMDA Receptor-Initiated Signaling via Arachidonic Acid in Unanesthetized Rats

Basselin

Chang

Bell

et al. 2005

Neuropsychopharmacol

106

132

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It has been proposed that lithium is effective in bipolar disorder (BD) by inhibiting glutamatergic neurotransmission, particularly via N-methyl-D-aspartate receptors (NMDARs). To test this hypothesis and to see if the neurotransmission could involve the NMDARmediated activation of phospholipase A 2 (PLA 2 ), to release arachidonic acid (AA) from membrane phospholipid, we administered subconvulsant doses of NMDA to unanesthetized rats fed a chronic control or LiCl diet. We used quantitative autoradiography following the intravenous injection of radiolabeled AA to measure regional brain incorporation coefficients k* for AA, which reflect receptormediated activation of PLA 2 . In control diet rats, NMDA (25 and 50 mg/kg i.p.) compared with i.p. saline increased k* significantly in 49 and 67 regions, respectively, of the 83 brain regions examined. The regions affected were those with reported NMDARs, including the neocortex, hippocampus, caudate-putamen, thalamus, substantia nigra, and nucleus accumbens. The increases could be blocked by pretreatment with the specific noncompetitive NMDA antagonist MK-801 ((5R,10S)-( + )-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5,10-imine hydrogen maleate) (0.3 mg/kg i.p.), as well by a 6-week LiCl diet sufficient to produce plasma and brain lithium concentrations known to be effective in BD. MK-801 alone reduced baseline values for k* in many brain regions. The results show that it is possible to image NMDA signaling via PLA 2 activation and AA release in vivo, and that chronic lithium blocks this signaling, consistent with its suggested mechanism of action in BD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Chronic Lithium Chloride Administration Attenuates Brain NMDA Receptor-Initiated Signaling via Arachidonic Acid in Unanesthetized Rats

Basselin

Chang

Bell

et al. 2005

Neuropsychopharmacol

106

132

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“…Unilateral injection of AMPA into the Nacc shell elicited contraversive pivoting and this effect was inhibited by the AMPAreceptor antagonist NBQX (1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide), indicating that unilateral stimulation of AMPA receptors in the Nacc shell elicits contraversive pivoting, which pattern is identical to that induced by unilateral stimulation of dopamine receptors in the Nacc shell (35). The contraversive pivoting induced by stimulation of AMPA receptors in the Nacc shell was inhibited by the dopamine D 1 /D 2 -receptor antagonist cis-(Z)-flupenthixol injected into the same area (35), indicating that the contraversive pivoting elicited by the stimulation of AMPA receptors in the Nacc shell requires intact dopaminergic neurotransmission in this brain region. Since AMPA-receptor stimulation has been found to enhance extracellular levels of dopamine in the Nacc (31), it has been suggested that stimulation of presynaptic AMPA receptors on dopaminergic terminals elicits contraversive pivoting (31,35).…”

Section: Glutamatementioning

confidence: 91%

“…The contraversive pivoting induced by stimulation of AMPA receptors in the Nacc shell was inhibited by the dopamine D 1 /D 2 -receptor antagonist cis-(Z)-flupenthixol injected into the same area (35), indicating that the contraversive pivoting elicited by the stimulation of AMPA receptors in the Nacc shell requires intact dopaminergic neurotransmission in this brain region. Since AMPA-receptor stimulation has been found to enhance extracellular levels of dopamine in the Nacc (31), it has been suggested that stimulation of presynaptic AMPA receptors on dopaminergic terminals elicits contraversive pivoting (31,35). In this context, it has to be stated that the stimulatory effects of AMPA receptors on dopamine release in the Nacc are not necessarily due to direct actions of this excitatory amino acid on dopaminergic terminals: indirect actions through intrinsic neurons or feedback loops cannot be excluded (36).…”

Section: Glutamatementioning

confidence: 95%

Nucleus Accumbens and Dopamine-Mediated Turning Behavior of the Rat: Role of Accumbal Non-dopaminergic Receptors

et al. 2012

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Abstract. Accumbal dopamine plays an important role in physiological responses and diseases such as schizophrenia, Parkinson's disease, and depression. Since the nucleus accumbens contains different neurotransmitters, it is important to know how they interact with dopaminergic function: this is because modifying accumbal dopamine has far-reaching consequences for the treatment of diseases in which accumbal dopamine is involved. This review provides a summary of these interactions, and our current knowledge about them are as follows: A) AMPA receptors are required for dopamine-dependent behavior and vice versa; NMDA receptors modulate the activity at the level of AMPA and/or dopamine D 1 receptors. B) GABA A , but not GABA B , receptors inhibit dopamine-dependent behavior. C) Nicotinic receptors are required for dopamine-dependent behavior, whereas muscarinic receptors inhibit dopamine-dependent behavior. D) α-Adrenoceptors inhibit dopamine-dependent behavior in contrast to β-adrenoceptors, which potentiate this behavior. E) μ-and δ 2 -opioid receptors elicit behavior that requires an intact dopaminergic function and δ 2 -opioid receptors modulate dopamine-dependent behavior. F) Orexin 2 receptors play an important, modifying role in dopamine-dependent behavior. G) Somatostatin receptors potentiate dopamine-dependent behavior. It is suggested that modulation of the above-mentioned nondopaminergic receptors provide new tools to control physiological functions as well as diseases mediated by accumbal dopamine.

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“…Drug dosages were based on reported effective doses in other models employing site-specific central administration of these compounds [12,26]. Drug administration was via injection cannulae that extended 1 mm beyond the end of the guide cannulae.…”

Section: Behavioral Testingmentioning

confidence: 99%

Ventral tegmental area involvement in pair bonding in male prairie voles

Curtis

Wang

2005

Physiology & Behavior

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Dopamine is known to play a critical role in social attachment in monogamous voles. However, little is known about the neurochemical regulation of central dopamine release during pair bond formation. Here we examine the effects on partner preference formation in male prairie voles of neurochemical manipulations in the ventral tegmental area (VTA), a major source of dopamine to brain regions implicated in pair bonding. Administration of NBQX, an AMPA receptor antagonist, or bicuculline, a GABA receptor antagonist, into the VTA induced partner preferences within 6 h in the absence of mating. We also found that, after unilateral administration of NBQX into the VTA, neuronal activation, as indicated by the expression of the immediate early gene c-fos, was decreased in the nucleus accumbens, prefrontal cortex, and medial amygdala, but was unchanged in the lateral septum and in a control region, the arcuate nucleus. These results confirm a role for the VTA in partner preference formation in monogamous voles and extend the list of neurochemicals important in pair bonding to include glutamate and GABA. D

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Role of AMPA and NMDA receptors in the nucleus accumbens shell in turning behaviour of rats: interaction with dopamine receptors

Cited by 27 publications

References 33 publications

Chronic Lithium Chloride Administration Attenuates Brain NMDA Receptor-Initiated Signaling via Arachidonic Acid in Unanesthetized Rats

Chronic Lithium Chloride Administration Attenuates Brain NMDA Receptor-Initiated Signaling via Arachidonic Acid in Unanesthetized Rats

Nucleus Accumbens and Dopamine-Mediated Turning Behavior of the Rat: Role of Accumbal Non-dopaminergic Receptors

Ventral tegmental area involvement in pair bonding in male prairie voles

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