Role of angiotensin II in the response to endothelin-1 of goat cerebral arteries after ischemia–reperfusion

Salcedo, Adely; Fernández, Núria; Villalón, A. L. García; Monge, Luis; Sánchez, Rodrigo; Diéguez, Godofredo

doi:10.1016/j.vph.2008.12.001

Cited by 5 publications

(7 citation statements)

References 23 publications

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“…Ang II potentiates vasoconstriction to ET-1 in cerebral arteries after ischemia and reperfusion but not under non-ischemic control conditions. 115 Activation of ET-1 receptors during ischemia and reperfusion has been shown to produce reactive oxygen (ROS) and nitrogen (RONS) species in an endothelium-dependent manner, that may be enhanced during hypertension in which ET-1 is elevated. 116 A previous study found that brain parenchymal arterioles (PAs) constricted to sarafotoxin, a selective ET B receptor agonist, only after tMCAO that was prevented by FeTMPyP to scavenge ONOO À , suggesting that ET-1 activation of ET B receptors on endothelium produces ONOO À to cause vasoconstriction.…”

Section: Endothelinmentioning

confidence: 99%

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The importance of comorbidities in ischemic stroke: Impact of hypertension on the cerebral circulation

Cipolla

Liebeskind

Chan

2018

J Cereb Blood Flow Metab

264

160

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Comorbidities are a hallmark of stroke that both increase the incidence of stroke and worsen outcome. Hypertension is prevalent in the stroke population and the most important modifiable risk factor for stroke. Hypertensive disorders promote stroke through increased shear stress, endothelial dysfunction, and large artery stiffness that transmits pulsatile flow to the cerebral microcirculation. Hypertension also promotes cerebral small vessel disease through several mechanisms, including hypoperfusion, diminished autoregulatory capacity and localized increase in blood-brain barrier permeability. Preeclampsia, a hypertensive disorder of pregnancy, also increases the risk of stroke 4-5-fold compared to normal pregnancy that predisposes women to early-onset cognitive impairment. In this review, we highlight how comorbidities and concomitant disorders are not only risk factors for ischemic stroke, but alter the response to acute ischemia. We focus on hypertension as a comorbidity and its effects on the cerebral circulation that alters the pathophysiology of ischemic stroke and should be considered in guiding future therapeutic strategies.

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Section: Endothelinmentioning

confidence: 99%

“…Ang II potentiates vasoconstriction to ET-1 in cerebral arteries after ischemia and reperfusion but not under non-ischemic control conditions. 115…”

Section: Vasoconstrictor Stimuli During Hypertensionmentioning

confidence: 99%

The importance of comorbidities in ischemic stroke: Impact of hypertension on the cerebral circulation

Cipolla

Liebeskind

Chan

2018

J Cereb Blood Flow Metab

264

160

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“…Thus, inhibition of A‐II synthesis might have a protective effect on IR injury. Several studies have reported that selective ARB and ACE inhibitors might reduce various IR‐induced tissue damage, such as myocardial, hepatic, renal, cerebral and intestinal 12–17 . The effects of these drugs were also investigated by Gokce et al .…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have reported that selective ARB and ACE inhibitors might reduce various IR-induced tissue damage, such as myocardial, hepatic, renal, cerebral and intestinal. [12][13][14][15][16][17] The effects of these drugs were also investigated by Gokce et al in a testicular IR model. They reported that administration of lisinopril, an ACE inhibitor, and losartan, an ARB, decreased the histopathological injury and apoptosis in the contralateral testes (non-ischemic), but they did not present the results of ipsilateral testes (ischemic).…”

Section: Introductionmentioning

confidence: 99%

Role of angiotensin and endothelin in testicular ischemia reperfusion injury

Turkili¹,

Kurçer²,

Dengiz³

et al. 2011

Int J of Urology

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Abbreviations & AcronymsObjectives: To determine whether angiotensin and endothelin have any role in testicular ischemia reperfusion injury by investigating the effects of the angiotensin converting enzyme inhibitor enalapril, selective non-peptide angiotensin-II type I blocker losartan and dual endothelin receptor blocker bosentan. Methods: Rats were anesthetized with thiopental sodium (50 mg/kg i.p.) before the operation. The left testicular artery and vein of rats were occluded for 1 h; before the bilateral orchiectomy, the organ was allowed to reperfuse for 3 h or 24 h. Enalapril (20 mg/kg i.p.), losartan (30 mg/kg i.p.), bosentan (10 mg/kg i.p.) or vehicle (saline) were given 30 min before reperfusion. Malondialdehyde level was measured in testicular tissue after 3 h of reperfusion. Histological examination was carried out after 24 h of reperfusion. Results: Ischemia reperfusion caused a significant increase in malondialdehyde level of ipsilateral testis, and histopathological injury in both ipsilateral and contralateral testes. Enalapril, losartan and bosentan treatments prevented the ischemia reperfusioninduced augmentation in malondialdehyde levels. Only bosentan treatment ameloriated ischemia reperfusion-induced histopathological alterations. Conclusions: Endothelin might play a more important role in pathogenesis of testicular ischemia reperfusion injury when compared with angiotensin.

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“…vasoconstriction and hypoperfusion) [ 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 ]. The molecular mechanism underlying these effects was attributed mainly to the activation of angiotensin II (ANG II) and the subsequent increase in the production of reactive oxygen species (ROS) and the activation of phospholipase C (PLC) [ 67 , 69 , 70 , 71 , 72 , 73 , 74 ]. Each of these pathways may activate a particular mechanism to increase the risk of stroke.…”

Section: Resultsmentioning

confidence: 99%

Molecular mechanisms underlying some major common risk factors of stroke

Alkahtani

2022

Heliyon

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Role of angiotensin II in the response to endothelin-1 of goat cerebral arteries after ischemia–reperfusion

Cited by 5 publications

References 23 publications

The importance of comorbidities in ischemic stroke: Impact of hypertension on the cerebral circulation

The importance of comorbidities in ischemic stroke: Impact of hypertension on the cerebral circulation

Role of angiotensin and endothelin in testicular ischemia reperfusion injury

Molecular mechanisms underlying some major common risk factors of stroke

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