Role of anthraquinones in Cassia occidentalis induced hepato-myo-encephalopathy

Shukla, Vibha; Asthana, Somya; Singh, Saurabh

doi:10.1016/j.jep.2020.113431

Cited by 6 publications

(6 citation statements)

References 61 publications

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“…S. occidentalis , commonly known as ‘ fedegoso ,’ is another native plant that is widely used in traditional medicine for hepatic diseases and is the subject of 10 usage reports [11,24–26,28,30,34,36,41,51] . It is important to mention that S. occidentalis seeds, which are highly toxic when ingested, are also consumed due to medicinal claims and are associated with potent harmful effects, including acute liver failure and hepatotoxicity [141–144] . However, the acute (14 days) and subacute (30 days) toxicological profile of a hydroalcoholic extract of S. occidentalis stems and leaves demonstrated that no mortality or toxic effects were induced after its oral administration in male and female rats [145] .…”

Section: Resultsmentioning

confidence: 99%

“…[11,[24][25][26]28,30,34,36,41,51] It is important to mention that S. occidentalis seeds, which are highly toxic when ingested, are also consumed due to medicinal claims and are associated with potent harmful effects, including acute liver failure and hepatotoxicity. [141][142][143][144] However, the acute (14 days) and subacute (30 days) toxicological profile of a hydroalcoholic extract of S. occidentalis stems and leaves demonstrated that no mortality or toxic effects were induced after its oral administration in male and female rats. [145] Jafri et al [93] evaluated the hepatoprotective activity of a hydroethanolic extract of the leaves from this species at an oral dose of 500 mg/kg against acetaminophen and alcohol intoxication in rats.…”

Section: Senna Occidentalis (L) Linkmentioning

confidence: 99%

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Hepatoprotective Native Plants Documented in Brazilian Traditional Medicine Literature: Current Knowledge and Prospects

Arbo

Konrath

2022

Chemistry & Biodiversity

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The native flora of Brazil covers a large biodiversity of plants, some of which have important pharmacological properties. Ethnobotanical studies have established that the folk use of plants for hepatobiliary disorders is very common in Brazil. This review aimed to compile, describe and discuss the main native Brazilian medicinal plants used as hepatoprotective agents listed on 25 books by authors from various regions in the country. Based on the 153 species found, a comprehensive analysis of the most relevant scientific studies is presented, including Piper umbellatum, Echinodorus macrophyllus, Fevillea trilobata and Achyrocline satureioides. Some medicinal plants share both a large number of citations and scientific evidence to corroborate their hepatoprotective effects, including Solanum paniculatum, Baccharis crispa and Phyllanthus niruri, which could be of interest to develop new phytomedicines. Additionally, some active ingredients are indicated as being responsible for the liver protective effects described, particularly phenolic compounds (flavonoids, coumestans and lignans).

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Section: Resultsmentioning

confidence: 99%

Section: Senna Occidentalis (L) Linkmentioning

confidence: 99%

Hepatoprotective Native Plants Documented in Brazilian Traditional Medicine Literature: Current Knowledge and Prospects

Arbo

Konrath

2022

Chemistry & Biodiversity

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“…Previous studies have shown that anthraquinones have various bioactivities . However, along with their widespread and frequent use, the health risks and safety issues of anthraquinones, − including hepatotoxicity, , nephrotoxicity, cardiotoxicity, and carcinogenicity, have been a cause for concern . Yang et al found that the anthraquinones of Cassiae seed water extract could lead to liver injury in rats .…”

Section: Introductionmentioning

confidence: 99%

Anthraquinone Removal from Cassia obtusifolia Seed Water Extract Using Baking, Stir-Frying, and Adsorption Treatments: Effects on the Chemical Composition, Physicochemical Properties of Polysaccharides, and Antioxidant Activities of the Water Extract

Liu

Yin

Huang

et al. 2023

J. Agric. Food Chem.

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Safety issues of the controversial anthraquinones from Cassia obtusifolia seed water extracts (CWEs) limit its application. This work aimed to remove the anthraquinones of CWEs by baking treatment (BT), stir-frying treatment (ST), and adsorption treatment (AT). Effects of these treatments on the chemical composition, physicochemical properties of polysaccharides, and antioxidant activities of CWEs were analyzed and compared. Results indicated that AT exhibited the best removal effect on the total anthraquinone among the three treatments. After AT, the contents of rhein, emodin, aloe-emodin, and aurantio-obtusin of the CWE were below the limit of detection. In addition, AT increased the contents of neutral sugars in CWEs in comparison to BT and ST. None of the treatments had an obvious influence on the structural characteristics of polysaccharides. However, AT decreased the antioxidant activity of CWEs due to their lower anthraquinone content. In summary, AT was considered as an efficient and simple method to remove anthraquinones, while retaining the features of polysaccharides.

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“…Anthraquinones isolated from roots and leaves of plants belonging to families Polygonaceae, Rhamnaceae, Rubiaceae, Fabaceae and Scrophulariaceae and from fungi and lichens show a wide range of therapeutic effects [6]. They have antihyperlipidemic, cholesterollowering, antiseptic, anticancer [7], and antimicrobial [8,9] properties.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, there is research into new methods of functionalization of anthraquinones, and into synthesis of co-polymeric nanostructures designed for photodynamic therapy [11]. Anthraquinones isolated from roots and leaves of plants belonging to families Polygonaceae, Rhamnaceae, Rubiaceae, Fabaceae and Scrophulariaceae and from fungi and lichens show a wide range of therapeutic effects [6]. They have antihyperlipidemic, cholesterollowering, antiseptic, anticancer [7], and antimicrobial [8,9] properties.…”

Section: Introductionmentioning

confidence: 99%

The Health Benefits of Emodin, a Natural Anthraquinone Derived from Rhubarb—A Summary Update

Stompor-Gorący

2021

IJMS

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Emodin (6-methyl-1,3,8-trihydroxyanthraquinone) is a naturally occurring anthraquinone derivative found in roots and leaves of various plants, fungi and lichens. For a long time it has been used in traditional Chinese medicine as an active ingredient in herbs. Among other sources, it is isolated from the rhubarb Rheum palmatum or tuber fleece-flower Polygonam multiflorum. Emodin has a wide range of biological activities, including diuretic, antibacterial, antiulcer, anti-inflammatory, anticancer and antinociceptive. According to the most recent studies, emodin acts as an antimalarial and antiallergic agent, and can also reverse resistance to chemotherapy. In the present work the potential therapeutic role of emodin in treatment of inflammatory diseases, cancers and microbial infections is analysed.

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Role of anthraquinones in Cassia occidentalis induced hepato-myo-encephalopathy

Cited by 6 publications

References 61 publications

Hepatoprotective Native Plants Documented in Brazilian Traditional Medicine Literature: Current Knowledge and Prospects

Hepatoprotective Native Plants Documented in Brazilian Traditional Medicine Literature: Current Knowledge and Prospects

Anthraquinone Removal from Cassia obtusifolia Seed Water Extract Using Baking, Stir-Frying, and Adsorption Treatments: Effects on the Chemical Composition, Physicochemical Properties of Polysaccharides, and Antioxidant Activities of the Water Extract

The Health Benefits of Emodin, a Natural Anthraquinone Derived from Rhubarb—A Summary Update

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