Role of Apelin/APJ axis in cancer development and progression

Masoumi, Javad; Jafarzadeh, Abdollah; Khorramdelazad, Hossein; Abbasloui, Morteza; Abdolalizadeh, Jalal; Jamali, Najmeh

doi:10.1016/j.advms.2020.02.002

Cited by 55 publications

(51 citation statements)

References 167 publications

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“…Emerging findings ascribed to apelin behave similarly to that of insulin as well as pro-inflammatory properties and a role in the regulation of blood pressure [ 138 , 139 , 140 , 141 ]. Moreover, it might contribute to obesity-related disorders [ 138 , 142 ] and to the development and progression of cancers [ 137 , 143 , 144 ]. The expression of apelin has been found to be increased in many types of cancers, where it might act as a potentially proangiogenic factor [ 137 , 144 , 145 , 146 ].…”

Section: The Involvement Of Adipokines In Cancer Cachexiamentioning

confidence: 99%

“…Moreover, it might contribute to obesity-related disorders [ 138 , 142 ] and to the development and progression of cancers [ 137 , 143 , 144 ]. The expression of apelin has been found to be increased in many types of cancers, where it might act as a potentially proangiogenic factor [ 137 , 144 , 145 , 146 ].…”

Section: The Involvement Of Adipokines In Cancer Cachexiamentioning

confidence: 99%

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The Adipokines in Cancer Cachexia

Mannelli

Gamberi

Magherini

et al. 2020

IJMS

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Cachexia is a devastating pathology induced by several kinds of diseases, including cancer. The hallmark of cancer cachexia is an extended weight loss mainly due to skeletal muscle wasting and fat storage depletion from adipose tissue. The latter exerts key functions for the health of the whole organism, also through the secretion of several adipokines. These hormones induce a plethora of effects in target tissues, ranging from metabolic to differentiating ones. Conversely, the decrease of the circulating level of several adipokines positively correlates with insulin resistance, metabolic syndrome, diabetes, and cardiovascular disease. A lot of findings suggest that cancer cachexia is associated with changed secretion of adipokines by adipose tissue. In agreement, cachectic patients show often altered circulating levels of adipokines. This review reported the findings of adipokines (leptin, adiponectin, resistin, apelin, and visfatin) in cancer cachexia, highlighting that to study in-depth the involvement of these hormones in this pathology could lead to the development of new therapeutic strategies.

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Section: The Involvement Of Adipokines In Cancer Cachexiamentioning

confidence: 99%

Section: The Involvement Of Adipokines In Cancer Cachexiamentioning

confidence: 99%

The Adipokines in Cancer Cachexia

Mannelli

Gamberi

Magherini

et al. 2020

IJMS

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“…Secretion and expression of APLN as a mitogenic factor was also detected in OVCAR3 cell line which regulates the proliferation progress in a dose-dependent manner (Hoffmann, Fiedor & Ptak, 2017). In SKOV3 cell line, over-expressed APLN and its receptor reduced the sensitivity of anti-angiogenic therapeutic regimen (Masoumi et al, 2020). Recently, an elevated APELA level was documented in various histotypes of ovarian cancers, especially in ovarian clear cell carcinoma (OCCC) (Yi et al, 2017).…”

Section: Roles Of Apln and Apela In Ovarian Cancermentioning

confidence: 99%

Emerging roles of APLN and APELA in the physiology and pathology of the female reproductive system

Liu

Song

Shen

et al. 2020

PeerJ

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APLN, APELA and their common receptor APLNR (composing the apelinergic axis) have been described in various species with extensive body distribution and multiple physiological functions. Recent studies have witnessed emerging intracellular cascades triggered by APLN and APELA which play crucial roles in female reproductive organs, including hypothalamus-pituitary-gonadal axis, ovary, oviduct, uterus and placenta. However, a comprehensive summary of APLN and APELA roles in physiology and pathology of female reproductive system has not been reported to date. In this review, we aim to concentrate on the general characteristics of APLN and APELA, as well as their specific physiological roles in female reproductive system. Meanwhile, the pathological contexts of apelinergic axis dysregulation in the obstetrics and gynecology are also summarized here, suggesting its potential prospect as a diagnostic biomarker and/or therapeutic intervention in the polycystic ovary syndrome, ovarian cancer, preeclampsia and gestational diabetes mellitus.

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“…Secretion and expression of APLN as a mitogenic factor was also detected in OVCAR3 cell line which regulates the proliferation progress in a dose-dependent manner (Hoffmann, Fiedor & Ptak, 2017). In SKOV3 cell line, over-expressed APLN and its receptor reduced the sensitivity of antiangiogenic therapeutic regimen (Masoumi et al, 2020). Recently, an elevated APELA level was documented in various histotypes of ovarian cancers, especially in ovarian clear cell carcinoma (OCCC) (Yi et al, 2017).…”

Section: Roles Of Apln and Apela In Ovarian Cancermentioning

confidence: 99%

Peer Review #1 of "Emerging roles of APLN and APELA in the physiology and pathology of the female reproductive system (v0.1)"

2020

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Role of Apelin/APJ axis in cancer development and progression

Cited by 55 publications

References 167 publications

The Adipokines in Cancer Cachexia

The Adipokines in Cancer Cachexia

Emerging roles of APLN and APELA in the physiology and pathology of the female reproductive system

Peer Review #1 of "Emerging roles of APLN and APELA in the physiology and pathology of the female reproductive system (v0.1)"

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