2001
DOI: 10.1161/hq1001.097106
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Role of Arterial Wall Antioxidant Defense in Beneficial Effects of Exercise on Atherosclerosis in Mice

Abstract: Abstract-The mechanism(s) by which exercise reduces atherogenic risk remains unknown. This study tested the hypothesis that sustained exercise-induced oxidative stress may increase antioxidant defense in the arterial wall. Acute exercise induced an increase in antibodies to oxidatively modified proteins and catalase in the aortic walls of normal mice compared with sedentary control mice. In male atherogenic diet-fed low density lipoprotein (LDL) receptordeficient mice, exercise lowered plasma cholesterol (15%)… Show more

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Cited by 109 publications
(103 citation statements)
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“…In addition, we observed an exercise-induced increase in aortic iNOS protein expression that was also observed in another study (61). Overall, exercise-related induction of scavenger enzymes observed in the present study was consistent with previous observations (28)(29)(30)(31)(32)(33). The mild oxidative stress induced by graduated exercise could be responsible for its beneficial effects on atherosclerosis, perhaps by inducing vascular antioxidant defenses.…”
Section: Discussionsupporting
confidence: 92%
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“…In addition, we observed an exercise-induced increase in aortic iNOS protein expression that was also observed in another study (61). Overall, exercise-related induction of scavenger enzymes observed in the present study was consistent with previous observations (28)(29)(30)(31)(32)(33). The mild oxidative stress induced by graduated exercise could be responsible for its beneficial effects on atherosclerosis, perhaps by inducing vascular antioxidant defenses.…”
Section: Discussionsupporting
confidence: 92%
“…Moreover, both plasma and tissue oxidative stress were reduced and eNOS expression was increased in the aorta of these animals. The induction of eNOS by exercise has been reported (32,36,59,60). In addition, we observed an exercise-induced increase in aortic iNOS protein expression that was also observed in another study (61).…”
Section: Discussionsupporting
confidence: 88%
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