Role of Aryl Urea Containing Compounds in Medicinal Chemistry

Sikka, Pratiksha

doi:10.4172/2161-0444.1000305

Cited by 43 publications

(11 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…molecule 167, the HPLC-MS reported fragmentations corresponding to the loss of the isopropyl group in para position to the urea, and corresponding to the hydroxy group on the urea group (specifically, on the nitrogen atom directly bonded to the aromatic ring). All the by-products identified are phenyl ureas, which possess a pharmacological action as anticonvulsant, antimicrobial, antiviral and anti inflammatory agents [44]. Photocatalysis is unable to degrade aryl intermediates in 6 h, yielding a wastewater that may be either as toxic or more toxic than isoproturon-contaminated water.…”

Section: By-products Analysismentioning

confidence: 99%

An ultrasound-assisted photocatalytic treatment to remove an herbicidal pollutant from wastewaters

Schieppati

Galli

Peyot

et al. 2019

Ultrasonics Sonochemistry

View full text Add to dashboard Cite

Pollutants of emerging concern contaminate surface and ground water. Advanced oxidation processes treat these molecules and degrade them into smaller compounds or mineralization products. However, little information on coupled advanced oxidation techniques and on the degradation pathways of these pollutants is available to identify possible ecotoxic subproducts. In the present work, we investigate the ultrasound assisted photocatalytic degradation pathway of the herbicide Isoproturon. We worked in batch mode in a thermostatic glass reactor. We compared the activity of nanometric TiO 2 P25 with that of Kronos 1077, a micrometric TiO 2. We discuss the individual, additive and synergistic degradation action of photolysis, sonolysis, sonophotolysis, and sonophotocatalysis by varying catalyst loading and/or ultrasound power for the last three techniques. With 0.1 g L −1 catalyst, photocatalysis and sonophotopcatalysis completely degrade Isoproturon within 240 min and 60 min, respectively (> 99 % conversion). Sonophotocatalysis breaks Isoproturon down into smaller molecules than photocatalysis alone.

show abstract

Section: By-products Analysismentioning

confidence: 99%

An ultrasound-assisted photocatalytic treatment to remove an herbicidal pollutant from wastewaters

Schieppati

Galli

Peyot

et al. 2019

Ultrasonics Sonochemistry

View full text Add to dashboard Cite

show abstract

“…24 In recent years, urea containing compounds have received much attention due to their growing application in drug design and medicinal chemistry. 25,26 In the present perspective, we plan to outline physicochemical properties of urea derivatives, highlighting the key role of the urea functionality in the drug− target interaction. We outline the chemical methodologies for the synthesis of urea derivatives.…”

Section: Introductionmentioning

confidence: 99%

Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry

2019

View full text Add to dashboard Cite

The urea functionality is inherent to numerous bioactive compounds, including a variety of clinically approved therapies. Urea containing compounds are increasingly used in medicinal chemistry and drug design in order to establish key drug−target interactions and fine-tune crucial drug-like properties. In this perspective, we highlight physicochemical and conformational properties of urea derivatives. We provide outlines of traditional reagents and chemical procedures for the preparation of ureas. Also, we discuss newly developed methodologies mainly aimed at overcoming safety issues associated with traditional synthesis. Finally, we provide a broad overview of urea-based medicinally relevant compounds, ranging from approved drugs to recent medicinal chemistry developments.

show abstract

“…Diarylureas or bis-arylureas are generally known as anticancer agents [ 14 ], for instance sorafenib, regorafenib, linifanib, tivozanib, and ripretinib, which have been recently reviewed by our research group [ 15 ]. Nevertheless, it is reported that they have also a lot of different and important biological activities [ 16 , 17 ]. Indeed, they are antimicrobials, particularly active in schistosomiasis and malaria [ 18 , 19 , 20 ], anti-inflammatory, antiplatelet, and antiviral agents [ 21 , 22 ], and allosteric modulators of the cannabinoid CB1 receptor [ 23 ], VLA-4 integrin antagonists [ 24 ], and EGFR inhibitors [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Diarylureas: Repositioning from Antitumor to Antimicrobials or Multi-Target Agents against New Pandemics

et al. 2021

View full text Add to dashboard Cite

Antimicrobials have allowed medical advancements over several decades. However, the continuous emergence of antimicrobial resistance restricts efficacy in treating infectious diseases. In this context, the drug repositioning of already known biological active compounds to antimicrobials could represent a useful strategy. In 2002 and 2003, the SARS-CoV pandemic immobilized the Far East regions. However, the drug discovery attempts to study the virus have stopped after the crisis declined. Today’s COVID-19 pandemic could probably have been avoided if those efforts against SARS-CoV had continued. Recently, a new coronavirus variant was identified in the UK. Because of this, the search for safe and potent antimicrobials and antivirals is urgent. Apart from antiviral treatment for severe cases of COVID-19, many patients with mild disease without pneumonia or moderate disease with pneumonia have received different classes of antibiotics. Diarylureas are tyrosine kinase inhibitors well known in the art as anticancer agents, which might be useful tools for a reposition as antimicrobials. The first to come onto the market as anticancer was sorafenib, followed by some other active molecules. For this interesting class of organic compounds antimicrobial, antiviral, antithrombotic, antimalarial, and anti-inflammatory properties have been reported in the literature. These numerous properties make these compounds interesting for a new possible pandemic considering that, as well as for other viral infections also for CoVID-19, a multitarget therapeutic strategy could be favorable. This review is meant to be an overview on diarylureas, focusing on their biological activities, not dwelling on the already known antitumor activity. Quite a lot of papers present in the literature underline and highlight the importance of these molecules as versatile scaffolds for the development of new and promising antimicrobials and multitarget agents against new pandemic events.

show abstract

Role of Aryl Urea Containing Compounds in Medicinal Chemistry

Cited by 43 publications

References 18 publications

An ultrasound-assisted photocatalytic treatment to remove an herbicidal pollutant from wastewaters

An ultrasound-assisted photocatalytic treatment to remove an herbicidal pollutant from wastewaters

Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry

Diarylureas: Repositioning from Antitumor to Antimicrobials or Multi-Target Agents against New Pandemics

Contact Info

Product

Resources

About