Role of ascorbic acid in diabetes mellitus: A comprehensive review

Santosh, H. N.; David, Chaya M

doi:10.15713/ins.jmrps.79

Cited by 30 publications

(27 citation statements)

References 9 publications

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“…Thus, doses of vitamin C will boost insulin sensitivity and endothelium function in diabetics or individuals expressing vitamin C deficiency [59]. Vitamin C prevents sorbitol accumulation and glycosylation of proteins and thus reduces the microvascular complications of T1DM and T2DM, such as retinopathy, nephropathy, and diabetic foot [60]. In a study, administration of vitamin C alone or combined with vitamin E reduced blood glucose and increased superoxide dismutase and glutathione levels, resulting in reduced insulin resistance by lowering oxidative stress [61].…”

Section: Vitamin C (Ascorbic Acid and Ascorbyl Palmitate)mentioning

confidence: 99%

Mechanistic links between vitamin deficiencies and diabetes mellitus: a review

Yahaya

Yusuf

Danjuma

et al. 2021

Egyptian Journal of Basic and Applied Sciences

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Vitamin deficiencies are suspected of causing the increasing prevalence of diabetes mellitus. However, this subject has not received adequate attention. This study reviews and communicates the plausible links between vitamin deficiencies and DM. Relevant articles were retrieved from reputable academic databases and the current information revealed that vitamins of primary importance in the pathogenesis of DM are vitamins A, C, D, E, and B-vitamins. Vitamin A enhances beta-cell formation and glucose metabolism. B-vitamins lower homocysteine levels and thus prevent oxidative stress, endothelial dysfunction, β-cell dysfunction, and insulin resistance. Vitamin C reduces free radicals and enhances superoxide dismutase, glutathione, and blood glucose circulation. Vitamin D prevents autoimmunity and promotes cellular and systemic uptake insulin. Vitamin E reduces free radicals and C -reactive proteins, prevents lipid peroxidation, and improves insulin function. These vitamin deficiencies can result in beta-cell abnormalities, insulin resistance, and insulin insufficiency. The major causes of vitamin deficiencies are low dietary supplementation, malabsorption, diseases, and lifestyle. Fortunately, dietary or therapeutic administration of these vitamins can reverse or delay the mentioned pathologies, resulting in improved diabetic conditions. Therefore, people are advised to consider vitamin intervention in the prevention and treatment of diabetic cases having a vitamin deficiency etiology.

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Section: Vitamin C (Ascorbic Acid and Ascorbyl Palmitate)mentioning

confidence: 99%

Mechanistic links between vitamin deficiencies and diabetes mellitus: a review

Yahaya

Yusuf

Danjuma

et al. 2021

Egyptian Journal of Basic and Applied Sciences

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“…Vitamin C or ascorbic acid (AA) is an essential nutrient with high antioxidant potential, obtained from the diet, whose structure is quite similar to carbohydrates (such as glucose) [ 162 ].…”

Section: Ros As Signalling Messengers Of Human Health Statusmentioning

confidence: 99%

Biomolecules and Electrochemical Tools in Chronic Non-Communicable Disease Surveillance: A Systematic Review

et al. 2020

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Over recent three decades, the electrochemical techniques have become widely used in biological identification and detection, because it presents optimum features for efficient and sensitive molecular detection of organic compounds, being able to trace quantities with a minimum of reagents and sample manipulation. Given these special features, electrochemical techniques are regularly exploited in disease diagnosis and monitoring. Specifically, amperometric electrochemical analysis has proven to be quite suitable for the detection of physiological biomarkers in monitoring health conditions, as well as toward the control of reactive oxygen species released in the course of oxidative burst during inflammatory events. Besides, electrochemical detection techniques involve a simple and swift assessment that provides a low detection-limit for most of the molecules enclosed biological fluids and related to non-transmittable morbidities.

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“…Hubungan asupan karbohidrat dengan gula darah puasa memiliki r sebesar 0,465; artinya memiliki korelasi yang sedang. 16,28 Vitamin C atau asam askorbat adalah vitamin larut air dan juga berperan sebagai antioksidan yang kuat. Vitamin C bekerja dengan cara mendonasikan elektronnya kepada lemak radikal guna mengakhiri reaksi rantai pada proses peroksidasi lemak.…”

Section: Hubungan Asupan Dan Aktivitas Fisik Dengan Kadar Gula Darah unclassified

“…16 Berdasarkan penelitian sebelumnya, diperlukan asupan vitamin C sebanyak 500 mg per hari untuk dapat menurunkan kadar gula darah puasa. 28 Penelitian yang dilakukan memperoleh hasil bahwa secara statistik tidak terdapat hubungan asupan vitamin E dengan kadar gula darah puasa (p=0,467). Hal ini dikarenakan rerata asupan vitamin E subjek tergolong kurang, hanya mencapai 9,18 mg per hari, sedangkan kebutuhan minimal vitamin E menurut AKG 2013 adalah 15 mg per hari.…”

Section: Hubungan Asupan Dan Aktivitas Fisik Dengan Kadar Gula Darah unclassified

Hubungan Asupan Vitamin C, Vitamin E Dan Β-Karoten Dengan Kadar Gula Darah Puasa Pada Wanita Usia 35-50 Tahun

2018

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Latar Belakang : Vitamin C, vitamin E dan β-karoten, yang merupakan bagian dari antioksidan non-enzimatik, memiliki peran besar dalam membantu melawan radikal bebas atau Reactive Oxygen/ Nitrogen Species (ROS/ RNS) yang menyerang tubuh. Vitamin C, vitamin E dan β-karoten dapat membantu dalam mengurangi risiko terjadinya resistensi insulin akibat dari ROS/ RNS yang merusak sel β pankreas. Tujuan penelitian adalah mengetahui hubungan asupan vitamin C, vitamin E dan β-karoten dengan kadar gula darah puasa pada wanita usia 35-50 tahun.Metode : Penelitian ini merupakan penelitian observasional dengan rancangan cross sectional. Tiga puluh dua subjek dipilih dengan metode consecutive sampling. Data asupan diperoleh melalui Semi Quantitative Food Frequency Questionnaire, kadar gula darah diuji dengan metode Glucose Oxidation, dan data aktivitas fisik diperoleh melalui International Physical Activity Questionnaire- Long Form. Data dianalisis menggunakan uji Rank-Spearman.Hasil : Rerata kadar gula darah puasa subjek 99,50±23,91 mg/dL dengan rerata asupan vitamin C 187,06±160,27 mg, vitamin E 9,18±4,46 mg dan β-karoten 13,32±12,86 mg. Sebesar 78,12% subjek memiliki asupan vitamin E yang kurang; 87,5% subjek dan 71,87% subjek memiliki asupan vitamin C dan β-karoten yang cukup.Simpulan : Tidak terdapat hubungan asupan vitamin C, vitamin E dan β-karoten dengan kadar gula darah puasa pada wanita usia 35-50 tahun.

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Role of ascorbic acid in diabetes mellitus: A comprehensive review

Cited by 30 publications

References 9 publications

Mechanistic links between vitamin deficiencies and diabetes mellitus: a review

Mechanistic links between vitamin deficiencies and diabetes mellitus: a review

Biomolecules and Electrochemical Tools in Chronic Non-Communicable Disease Surveillance: A Systematic Review

Hubungan Asupan Vitamin C, Vitamin E Dan Β-Karoten Dengan Kadar Gula Darah Puasa Pada Wanita Usia 35-50 Tahun

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