2019
DOI: 10.1016/j.jbo.2019.100235
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Role of autophagy in osteosarcoma

Abstract: Osteosarcoma (OS) is the most common primary bone tumour in children and adolescents. It is a highly aggressive tumor with a tendency to spread to the lungs, which are the most common site of metastasis. Advanced osteosarcoma patients with metastasis share a poor prognosis. Despite the use of chemotherapy to treat OS, the 5-year overall survival rate for patients has remained unchanged at 65–70% for the past 20 years. In addition, the 5-year survival of patients with a metastatic disease is around 20%, highlig… Show more

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Cited by 56 publications
(55 citation statements)
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“…The elimination and recycling of damaged proteins and organelles are driven by autophagy, which provides energy to the cells. Autophagy can be activated by chemotherapy and can promote increased chemosensitivity, as well as drug resistance in OS (Camuzard et al , 2019; Liao et al , 2019). Thus, drugs regulating autophagy may be an option to overcome drug resistance in the future.…”
Section: Epidemiology Of Sarcomamentioning
confidence: 99%
“…The elimination and recycling of damaged proteins and organelles are driven by autophagy, which provides energy to the cells. Autophagy can be activated by chemotherapy and can promote increased chemosensitivity, as well as drug resistance in OS (Camuzard et al , 2019; Liao et al , 2019). Thus, drugs regulating autophagy may be an option to overcome drug resistance in the future.…”
Section: Epidemiology Of Sarcomamentioning
confidence: 99%
“…Autophagy, initially discovered by Ohsumi in 1992 (who received the 2016 Nobel Prize in Physiology or Medicine for his outstanding contributions to the field), is a catabolic process via which cells eliminate and recycle their own damaged proteins and organelles to provide energy (9). There are three types of autophagy, including microautophagy, macroautophagy and chaperone-mediated autophagy (10).…”
Section: Introductionmentioning
confidence: 99%
“…The autophagic process can be mainly divided into 4 steps: i) Formation of the phagophore to wrap the damaged material; ii) elongation and closure of the phagophore followed by autophagosome generation; iii) fusion of autophagosomes and lysosomes to form autolysosomes; and iv) content degradation and recycling (9). Autophagy can be triggered under stressful conditions, such as starvation, hypoxia and cytotoxicity, to maintain cell survival by providing energy (11).…”
Section: Introductionmentioning
confidence: 99%
“…Osteosarcoma (OS) is the most common malignant tumor in orthopedics and has been indicated to occur predominantly in adolescents between 1-20 years of age (1,2). OS is characterized by high malignancy, invasion and early lung metastasis (3,4).…”
Section: Introductionmentioning
confidence: 99%