Role of Bile in Intestinal Motility After Massive Liver Resection in Conscious Rats

Ma, Chenghu; Shimura, Tatsuo; Suehiro, Taketoshi; Takahashi, Atsushi; Mochiki, Erito; Asao, Takayuki; Kuwano, Hiroyuki

doi:10.1016/j.jss.2008.02.011

Cited by 1 publication

(1 citation statement)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The latest studies have shown that bile secretion and excretion can affect the peak current amplitude and duration of MMC [9], and the MMC cycle is significantly shortened after subtotal hepatectomy [10]. Changes in intestinal flora can affect the progression of acute liver injury, and flora balance is beneficial to the recovery from liver injury and alleviation of abdominal distention, diarrhea, and other symptoms [11].…”

Section: Discussionmentioning

confidence: 99%

Changing Interdigestive Migrating Motor Complex in Rats under Acute Liver Injury

Liu

Zheng

et al. 2014

BioMed Research International

View full text Add to dashboard Cite

Gastrointestinal motility disorder is a major clinical manifestation of acute liver injury, and interdigestive migrating motor complex (MMC) is an important indicator. We investigated the changes and characteristics of MMC in rats with acute liver injury. Acute liver injury was created by d-galactosamine, and we recorded the interdigestive MMC using a multichannel physiological recorder and compared the indexes of interdigestive MMC. Compared with normal controls, antral MMC Phase I duration was significantly prolonged and MMC Phase III duration was significantly shortened in the rats with acute liver injury. The duodenal MMC cycle and MMC Phases I and IV duration were significantly prolonged and MMC Phase III duration was significantly shortened in the rats with acute liver injury. The jejunal MMC cycle and MMC Phases I and IV duration were significantly prolonged and MMC Phase III duration was significantly shortened in the rats with acute liver injury compared with normal controls. Compared with the normal controls, rats with acute liver injury had a significantly prolonged interdigestive MMC cycle, related mainly to longer MMC Phases I and IV, shortened MMC Phase III, and MMC Phase II characterized by increased migrating clustered contractions, which were probably major contributors to the gastrointestinal motility disorders.

show abstract

Section: Discussionmentioning

confidence: 99%