Role of bilirubin, vitamin C and ceruloplasmin as antioxidants in coronary artery disease [CAD]

Verma, Vikrant; Ramesh, V.; Tewari, Satyendra; Gupta, Rahul; Sinha, Nakul; Pandey, C. M.

doi:10.1007/bf02867403

Cited by 15 publications

(11 citation statements)

References 18 publications

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“…The findings of the present study are similar to those of the study conducted by Dubois Rande et al 30) and Mc Murray 31) which reported a significant rise in MDA level and lipid peroxidation, with a concomitant decrease in antioxidants in patients with unstable angina and chronic heart failure. The present study also concurs with studies of Verma et al,32) who demonstrated that there was a significant drop in antioxidant, whereas lipid peroxides were significantly higher in AMI patients, compared with controls. The findings of the present study are also in good agreement with those of the study conducted by Kharb 33) where significantly decreased levels of antioxidants and increased levels of lipid peroxides were reported.…”

Section: Discussionsupporting

confidence: 93%

Oxidative Stress, Endogenous Antioxidant and Ischemia-modified Albumin in Normolipidemic Acute Myocardial Infarction Patients

Kumar

Sivakanesan

Singh

2008

JOURNAL OF HEALTH SCIENCE

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Dyslipidemia appears to be a conventional risk factor for acute myocardial infarction (AMI). Several studies have reported decreased levels of antioxidants and increased levels of ischemia-modified albumin (IscMA) and lipid peroxides in dyslipidemic myocardial infarct patients. However, literature search reveals no reports of normolipidemic AMI patients with reference to antioxidants and IscMA studies. Therefore, this study determined the endogenous levels of antioxidants and IscMA in normolipidemic AMI patients so that prospective measures could be taken to avoid acute coronary complications. The serum lipid profile, albumin, uric acid, total bilirubin, malondialdehyde, conjugated dienes and IscMA levels were determined in 165 normolipidemic AMI patients and 165 age/sex-matched controls. In addition, serum lipid concentrations were estimated by enzymatic methods. Endogenous antioxidants were significantly decreased in AMI patients compared with controls. In parallel with this, serum malondialdehyde (MDA) and conjugated dienes were significantly increased in AMI patients compared with controls. IscMA levels were significantly increased in AMI patients compared with controls. As for the serum lipid profile, total cholesterol (TC), cholesterol in low density lipoprotein (LDL) and triglycerides (TG) were higher in AMI subjects. High-density lipoprotein (HDL)-to-cholesterol and LDL-cholesterol-to-HDLcholesterol ratios were also greater in AMI subjects. * To whom correspondence should be addressed: Department of However, HDL-cholesterol was lower in AMI patients than control. AMI is a multifactorial disease that can arise even in normolipidemic subjects. The present study suggests that measuring of serum antioxidants and IscMA in normolipidemic patients would provide an index of oxidative stress and ischemia due to structural modifications of circulating albumin in serum.

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Section: Discussionsupporting

confidence: 93%

Oxidative Stress, Endogenous Antioxidant and Ischemia-modified Albumin in Normolipidemic Acute Myocardial Infarction Patients

Kumar

Sivakanesan

Singh

2008

JOURNAL OF HEALTH SCIENCE

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“…[25] The possible causes behind low vitamin C maybe due to over consumption as antioxidants, over used in regeneration of vitamin E also may be due to low dietary intake. Vitamin C had negatively correlated with the severity of the disease as shown in (Table-6) this result was agreed with other reports, [19,26] this meaningful result revealed that as vitamin C become low the oxidative stress become worse and the disease become more severe.…”

Section: Discussionsupporting

confidence: 91%

The relation of serum vitamins C and E levels and the severity of angiographically defined coronary artery disease in Alsader Teaching Hospital in Basrah

Al-Dohan¹,

Jawad²,

AL-Rubaye³

et al. 2014

MJBU

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Objective: To assess the relationship between the serum concentrations of vitamins C & E and the severity of coronary artery disease. Subjects and methods: In a case-control study, we evaluated 200 patients who underwent coronary angiography at AL-Basrah Cardiac Center at Al-Sader Teaching Hospital, Basra, Iraq. They were separated into two groups of case (patients with CAD) and control (non CAD). Four milliliters of blood samples were taken for measuring vitamin E and C. For statistical analyses, chi-square test, Student's t-test, one-way ANOVA, and the logistic regression were used. Results: In the present study, 94 participants with CAD in the case group and 106 participants free of CAD in the control group were included in the analysis. At baseline, there were significant differences in serum vitamin C ,vitamin E and some cardiovascular risk factors(diabetes, hypertension and smoking habits) between the two groups (P < 0.05). Moreover, when other risk factors of CVD were included in the model, serum vitamin C (Odd Ratio (OR = 0.8, 95% CI= 0.68-0.92, P = 0.0001) and serum Vitamin E (OR = 0.66, 95% CI = 0.578-0.754, P = 0.0001) were associated with CAD. There were a significant (P < 0.05) statistical changes in the vitamin C and E among the three sub groups of CAD patients being more deficient as the disease become more severe. Conclusions: Low serum vitamin C and E concentrations were associated with CAD and related to its severity.

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“…Similarly, a decrease of 14–20% was objectified in triple vessel disease and of 39% in MI with increasing serum CP in CHD patients, compared to the non-MI group. An inverse relationship was found between the three antioxidants studied and coronary risk factor suggesting that greater care in traditional risk factors would maintain a high level of these antioxidants [ 20 ].…”

Section: Resultsmentioning

confidence: 99%

Ceruloplasmin and Coronary Heart Disease—A Systematic Review

et al. 2020

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Several studies indicate that oxidative stress might play a central role in the initiation and maintenance of cardiovascular diseases. It remains unclear whether ceruloplasmin acts as a passive marker of inflammation or as a causal mediator. To better understand the impact of ceruloplasmin blood levels on the risk of cardiovascular disease, and paying special attention to coronary heart disease, we conducted a search on the two most commonly used electronic databases (Medline via PubMed and EMBASE) to analyze current assessment using observational studies in the general adult population. Each study was quality rated using criteria developed by the US Preventive Services Task Force. Most of 18 eligible studies reviewed support a direct relationship between ceruloplasmin elevated levels and incidence of coronary heart disease. Our results highlight the importance of promoting clinical trials that determine the functions of ceruloplasmin as a mediator in the development of coronary heart disease and evaluate whether the treatment of elevated ceruloplasmin levels has a role in the prognosis or prevention of this condition.

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Role of bilirubin, vitamin C and ceruloplasmin as antioxidants in coronary artery disease [CAD]

Cited by 15 publications

References 18 publications

Oxidative Stress, Endogenous Antioxidant and Ischemia-modified Albumin in Normolipidemic Acute Myocardial Infarction Patients

Oxidative Stress, Endogenous Antioxidant and Ischemia-modified Albumin in Normolipidemic Acute Myocardial Infarction Patients

The relation of serum vitamins C and E levels and the severity of angiographically defined coronary artery disease in Alsader Teaching Hospital in Basrah

Ceruloplasmin and Coronary Heart Disease—A Systematic Review

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