Ceruloplasmin and Coronary Heart Disease—A Systematic Review

Abstract

Several studies indicate that oxidative stress might play a central role in the initiation and maintenance of cardiovascular diseases. It remains unclear whether ceruloplasmin acts as a passive marker of inflammation or as a causal mediator. To better understand the impact of ceruloplasmin blood levels on the risk of cardiovascular disease, and paying special attention to coronary heart disease, we conducted a search on the two most commonly used electronic databases (Medline via PubMed and EMBASE) to analyze current assessment using observational studies in the general adult population. Each study was quality rated using criteria developed by the US Preventive Services Task Force. Most of 18 eligible studies reviewed support a direct relationship between ceruloplasmin elevated levels and incidence of coronary heart disease. Our results highlight the importance of promoting clinical trials that determine the functions of ceruloplasmin as a mediator in the development of coronary heart disease and evaluate whether the treatment of elevated ceruloplasmin levels has a role in the prognosis or prevention of this condition.

Serum Ceruloplasmin as a Potential Clinical Biomarker in Atopic Dermatitis

“…In addition to metabolism of copper and iron, Cp is involved in coagulation, angiogenesis, defense against oxidative stress, and iron homeostasis 15 . Recent studies reported that Cp is also associated with psoriasis, type 2 diabetes, coronary heart disease, and obesity 16 17 18 19 . Although the underlying mechanism has yet to be elucidated, hypothetically, it is likely that Cp mediates the pathogenic effects via apoptosis, cytotoxicity, cell replication, increased oxidative stress and pathogenic gene activation 20 .…”

Micronutrient deficiencies in heart failure: Mitochondrial dysfunction as a common pathophysiological mechanism?

“…Therefore, an increase in serum copper and ceruloplasmin concentrations could also be the consequence of (sub‐)clinical inflammation and stress, but not necessarily the cause. However, the increase of serum copper, and secondarily of ceruloplasmin caused by myocardial infarction, seems not to be completely associated with an inflammatory response [163].…”

Regulatory miRNAs in Cardiovascular and Alzheimer’s Disease: A Focus on Copper

“…Recently, it evidence has been provided that supports a direct relationship between elevated ceruloplasmin levels and CVD. Individuals with high ceruloplasmin serum concentrations are more likely to have CVD [ 64 ]. Most of the studies analyzed in a recent systemic review by Arenas de Larriva and collaborators [ 64 ] showed a direct relationship between serum ceruloplasmin levels and the incidence of CVD.…”

“…Individuals with high ceruloplasmin serum concentrations are more likely to have CVD [ 64 ]. Most of the studies analyzed in a recent systemic review by Arenas de Larriva and collaborators [ 64 ] showed a direct relationship between serum ceruloplasmin levels and the incidence of CVD. The higher the patient’s serum ceruloplasmin level, the more likely the patient is to experience CVD complications.…”

“…The primary role of ceruloplasmin is to scavenge ROS, such as superoxide and hydrogen peroxide, so it may be relevant in the majority of biological mechanisms underlying CVD. It is hypothesized that with high levels of ROS, antioxidant systems such as Cu/Zn SOD, catalase, and glutathione are overwhelmed, and the structural integrity of ceruloplasmin is impaired [ 64 ].…”