Role of Body Mass and Physical Activity in Autonomic Function Modulation on Post-COVID-19 Condition: An Observational Subanalysis of Fit-COVID Study

Freire, Ana Paula Coelho Figueira; Lira, Fábio Santos; Morano, Ana Elisa von Ah; Pereira, Telmo; Coelho‐e‐Silva, Manuel J.; Caseiro, Armando; Christófaro, Diego Giulliano Destro; Júnior, Osmar Marchioto; Dorneles, Gilson Pires; Minuzzi, Luciéle Guerra; Pinho, Ricardo A.; Silva, Bruna Spolador de Alencar

doi:10.3390/ijerph19042457

Cited by 22 publications

(48 citation statements)

References 59 publications

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“…The subset of patients with a chronification of symptoms along with potential consequences have not been studied yet in post-COVID condition, focusing initially on the overall prevalence without a stratification of severity, duration and long-term impact. Additionally, some evidence suggests that female sex, the number of symptoms in the acute phase, age and body-mass index (BMI) are associated with post-COVID condition 23 , 24 . However, it is not yet clear which risk factors could be associated with a chronification of symptoms.…”

Section: Introductionmentioning

confidence: 99%

The chronification of post-COVID condition associated with neurocognitive symptoms, functional impairment and increased healthcare utilization

Nehme

Braillard

Chappuis

et al. 2022

Sci Rep

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Post-COVID condition is prevalent in 10–35% of cases in outpatient settings, however a stratification of the duration and severity of symptoms is still lacking, adding to the complexity and heterogeneity of the definition of post-COVID condition and its oucomes. In addition, the potential impacts of a longer duration of disease are not yet clear, along with which risk factors are associated with a chronification of symptoms beyond the initial 12 weeks. In this study, follow-up was conducted at 7 and 15 months after testing at the outpatient SARS-CoV-2 testing center of the Geneva University Hospitals. The chronification of symptoms was defined as the continuous presence of symptoms at each evaluation timepoint (7 and 15 months). Adjusted estimates of healthcare utilization, treatment, functional impairment and quality of life were calculated. Logistic regression models were used to evaluate the associations between the chronification of symptoms and predictors. Overall 1383 participants were included, with a mean age of 44.3 years, standard deviation (SD) 13.4 years, 61.4% were women and 54.5% did not have any comorbidities. Out of SARS-CoV-2 positive participants (n = 767), 37.0% still had symptoms 7 months after their test of which 47.9% had a resolution of symptoms at the second follow-up (15 months after the infection), and 52.1% had persistent symptoms and were considered to have a chronification of their post-COVID condition. Individuals with a chronification of symptoms had an increased utilization of healthcare resources, more recourse to treatment, more functional impairment, and a poorer quality of life. Having several symptoms at testing and difficulty concentrating at 7 months were associated with a chronification of symptoms. COVID-19 patients develop post-COVID condition to varying degrees and duration. Individuals with a chronification of symptoms experience a long-term impact on their health status, functional capacity and quality of life, requiring a special attention, more involved care and early on identification considering the associated predictors.

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Section: Introductionmentioning

confidence: 99%

The chronification of post-COVID condition associated with neurocognitive symptoms, functional impairment and increased healthcare utilization

Nehme

Braillard

Chappuis

et al. 2022

Sci Rep

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“…However, the authors did not control their findings by body mass index (BMI) and the severity of cases, i.e., whether there was a need for in-patient or ICU admission for treatment of COVID-19. This is a relevant factor since the need for intubation or oxygen support may be correlated with greater deficits in respiratory capacity, which are more frequent in patients with obesity ( Freire et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Body composition and cardiorespiratory fitness in overweight or obese people post COVID-19: A comparative study

et al. 2022

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The present study aimed to evaluate the body composition and cardiorespiratory fitness of overweight or obese people after COVID-19. 171 volunteers of both sexes (men, n = 93 and women, n = 78) between 19 and 65 years old were allocated into three groups according to the severity of their symptoms of COVID-19: non-hospitalized people/mild symptoms (n = 61), hospitalized (n = 58), and hospitalized in an intensive care unit-ICU (n = 52). Two laboratory visits were carried out 24 h apart. First, a medical consultation was carried out, with subsequent measurement of body weight and height (calculation of body mass index) and body composition assessment via electrical bioimpedance. After 24 h, a cardiorespiratory test was performed using the Bruce protocol, with a direct gas exchange analysis. Hospitalized individuals had significantly higher values for fat mass and body fat percentage than non-hospitalized individuals (p < 0.05). Significantly higher values were found for heart rate (HR) and peak oxygen consumption (VO2peak) for individuals who were not hospitalized when compared to those hospitalized in the ICU (p < 0.05). Significantly higher values for distance, ventilation, and the relationship between respiratory quotient were found for non-hospitalized individuals compared to hospitalized individuals and those in the ICU (p < 0.05). After the cardiorespiratory test, higher values for peripheral oxygen saturation (SpO2) were observed for non-hospitalized individuals than for all hospitalized individuals (p < 0.05). Diastolic blood pressure was significantly higher at the tenth and fifteenth minute post-Bruce test in hospitalized than in non-hospitalized participants (p < 0.05). Based on these results, proposals for cardiopulmonary rehabilitation are indispensable for hospitalized groups considering the responses of blood pressure. Monitoring HR, SpO2, and blood pressure are necessary during rehabilitation to avoid possible physical complications. Volume and intensity of exercise prescription should respect the physiologic adaptation. Given lower physical conditioning among all the groups, proposals for recovering from health conditions are urgent and indispensable for COVID-19 survivors.

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“…Among cardiac mechanisms, poor HR variability or blunted HR associated with autonomic dysfunction have been proposed as pathophysiological mechanisms. 21 22 …”

Section: Discussionmentioning

confidence: 99%

Effect of a home-based inspiratory muscular training programme on functional capacity in patients with chronic COVID-19 after a hospital discharge: protocol for a randomised control trial (InsCOVID trial)

et al. 2022

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IntroductionExercise intolerance and fatigue are the most common symptoms in patients with chronic COVID-19 after hospital discharge. Supervised exercise training programmes improve symptoms, but scarce research has been done on home-based exercise programmes on the maximal functional capacity for discharged symptomatic COVID-19 patients. This study evaluates whether a home-based inspiratory muscle training (IMT) programme improves maximal functional capacity in chronic COVID-19 after hospital admission.Methods and analysisThis single-centre, assessor-blinded randomised controlled trial, powered for superiority, seeks to evaluate maximal functional capacity as the primary endpoint. A total of 26 eligible patients with a previous admission for acute respiratory syndrome coronavirus 2 pneumonia (>3 months after hospital discharge) will be randomised (1:1) to receive a 12-week programme of IMT versus usual care alone. A blinded assessor will measure outcomes at baseline and after the intervention (12 weeks). An analysis of variance will be used to compare continuous outcomes among the two-intervention groups. As of 21 March 2022, eight patients have been enrolled.Ethics and disseminationThe research ethics committee (Comité Ético de Investigación con Medicamentos de l'Hospital Clínic Universitari de València) approved the protocol following the principles of the Declaration of Helsinki and national regulations (Approval Number: 021/226). Findings will be published in peer-reviewed journals and conference publications.Trial registration numberNCT05279430.

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Role of Body Mass and Physical Activity in Autonomic Function Modulation on Post-COVID-19 Condition: An Observational Subanalysis of Fit-COVID Study

Cited by 22 publications

References 59 publications

The chronification of post-COVID condition associated with neurocognitive symptoms, functional impairment and increased healthcare utilization

The chronification of post-COVID condition associated with neurocognitive symptoms, functional impairment and increased healthcare utilization

Body composition and cardiorespiratory fitness in overweight or obese people post COVID-19: A comparative study

Effect of a home-based inspiratory muscular training programme on functional capacity in patients with chronic COVID-19 after a hospital discharge: protocol for a randomised control trial (InsCOVID trial)

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