2018
DOI: 10.1177/1933719117732161
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Role of Brain-Derived Neurotrophic Factor in Endometriosis Pain

Abstract: Brain-derived neurotrophic factor (BDNF) is a regulator for the formation and maintenance of chronic pain in various chronic disorders and has been shown to increase in the serum of women with endometriosis. However, BDNF expression in the peritoneal fluid (PF) and ectopic lesions and its role in endometriosis pain remain unclear. Thus, this study aims to determine the BDNF concentrations in serum and PFs and BDNF expression levels in ectopic lesions and endometriotic stromal cells (ESCs) of women with endomet… Show more

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Cited by 40 publications
(42 citation statements)
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“…In addition, BDNF may be a key factor in chronic pelvic pain of endometriosis, and is an effector of estrogen in endometrial cells, thus affecting cell growth (Dong et al, 2017;Ding et al, 2018). Furthermore, BDNF is the potential target of oleic acid, based on the results of network pharmacology.…”
Section: The Pain Relief Functionmentioning
confidence: 99%
“…In addition, BDNF may be a key factor in chronic pelvic pain of endometriosis, and is an effector of estrogen in endometrial cells, thus affecting cell growth (Dong et al, 2017;Ding et al, 2018). Furthermore, BDNF is the potential target of oleic acid, based on the results of network pharmacology.…”
Section: The Pain Relief Functionmentioning
confidence: 99%
“…Endometrial epithelial cells remaining in the cell strainer were collected were cultivated in primary epithelial growth medium (PriCells, Wuhan, China) and endometrial stromal cells were cultivated in Dulbecco's modified Eagle's medium (DMEM)/F12 medium (Thermo Fisher, CA, USA) supplemented with 10% FBS (Sigma-Aldrich, MO, USA). Identification of the isolated endometrial epithelial cells and stromal cells was assessed with anti-cytokeratin and anti-vimentin antibodies by immunohistochemistry as described in our previous study [22].…”
Section: Isolation and Identification Of Endometrial Stromal And Epitmentioning
confidence: 99%
“…21 The isolated endometrial epithelial cells and stromal cells were identified by immunofluorescent staining using epithelial marker pancytokeratin and mesenchymal marker vimentin as described in our previous study.…”
Section: Isolation and Identification Of Endometrial Epithelial Andmentioning
confidence: 99%