Role of calcineurin biosignaling in cell secretion and the possible regulatory mechanisms

Alothaid, Hani; Aldughaim, Mohammed S.; Alamri, Sawsan S.; Alrahimi, Jehan; Al-Jadani, Saeedah

doi:10.1016/j.sjbs.2020.08.042

Cited by 8 publications

(5 citation statements)

References 52 publications

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“…In comparing the salinity effects, we observed the highest number of DEGs (3,161) at t2h at Sal.16 compared to t2h at Sal. 45. Conversely, the lowest number of DEGs (411) were detected in the same comparison at t2h at Sal.…”

Section: Differential Gene Expression Over Time Under Lowered Salinitymentioning

confidence: 81%

“…Conversely, the lowest number of DEGs (411) were detected in the same comparison at t2h at Sal. 45 compared to t2h at Sal.16 (Supplementary Fig. 2).…”

Section: Differential Gene Expression Over Time Under Lowered Salinitymentioning

confidence: 97%

“…5 and Supplementary Table 5). The CaM-PK can activate a Ca 2+ -dependent calcineurin phosphatase (apaH), which is regulated by intracellular Ca 2+ levels and acts as a signaling intermediate 44,45 . ApaH gene expression was upregulated between t0h to t6h at Sal.16 when compared to Sal.22, and potentially inhibits further generation of intracellular reactive oxygen species (ROS) 46 .…”

Section: Other Stress-response Genesmentioning

confidence: 99%

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Stress responses in an Arctic microalga (Pelagophyceae) following sudden salinity change revealed by gene expression analysis

Freyria,

de Oliveira,

Chovatia

et al. 2024

Preprint

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Marine microbes that have for eons been adapted to stable salinity regimes are confronted with sudden decreases in salinity in the Arctic Ocean. The episodic freshening is increasing due to climate change with melting multi-year sea-ice and glaciers, and greater inflows from rivers, and increased precipitation. To investigate algal responses to lowered salinity, we analysed the responses and acclimatation over 24h in a non-model Arctic marine alga (pelagophyte CCMP2097) following transfer to realistic lower salinities. Using RNA-seq transcriptomics, here we show rapid differentially expressed genes related to stress oxidative responses, proteins involved in the photosystem and circadian clock, and those affecting lipids and inorganic ions. After 24h the pelagophyte adjusted to the lower salinity seen in the overexpression of genes associated with freezing resistance, cold adaptation, and salt tolerance. Overall, a suite of ancient widespread pathways is recruited enabling the species to adjust to the stress of rapid salinity change.

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Section: Differential Gene Expression Over Time Under Lowered Salinitymentioning

confidence: 81%

“…Conversely, the lowest number of DEGs (411) were detected in the same comparison at t2h at Sal. 45 compared to t2h at Sal.16 (Supplementary Fig. 2).…”

Section: Differential Gene Expression Over Time Under Lowered Salinitymentioning

confidence: 97%

Section: Other Stress-response Genesmentioning

confidence: 99%

See 1 more Smart Citation

Stress responses in an Arctic microalga (Pelagophyceae) following sudden salinity change revealed by gene expression analysis

Freyria,

de Oliveira,

Chovatia

et al. 2024

Preprint

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“…Calcium is one of the important intracellular messengers. 19 Due to intraoperative lavage fluid absorption, surgical stress state and large wound areas, cell membrane damage in patients is increased, leading to a large number of intracellular calcium ion transfer, and decreased blood calcium levels. Calcium influx elevates the concentration of calcium in the cytoplasm of cells, which activates calcium-regulated enzymes such as protease and phosphodiesterase, leading to local tissue and cell dysfunction.…”

Section: Discussionmentioning

confidence: 99%

The association between preoperative blood calcium and postoperative blood loss in patients undergoing heart valve replacement surgery

Dai

Zhou

et al. 2022

Perfusion

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Introduction Bleeding after heart valve surgery is a serious clinical challenge. Hypocalcemia has been associated with the extent of bleeding in patients with spontaneous intracerebral hemorrhage. However, the association between blood calcium levels and bleeding extent in heart valve replacement patients has not been clearly established. This study aimed at determining the association between blood calcium levels and perioperative hemorrhage after heart valve replacement therapy. Methods Based on preoperative blood calcium levels, patients were grouped into the hypocalcemia group and normocalcemia group. Postoperative bleeding, blood product use, and complications were monitored during hospitalization. The association between blood calcium levels and major bleeding was determined by multivariable logistic regression models. Results In the first 12 h after surgery, bleeding in hypocalcemia group was significantly larger than that of the normocalcemia group (338 ± 234 mL vs 232 ± 96 mL; p = .024). The outcome was the same when the overall chest tube output was considered (950 ± 447 mL vs 738 ± 220 mL; p = .038). The incidence of major bleeding was 65.91% in the hypocalcemia group and 18.97% in the normocalcemia group ( p = .001). Postoperative complications in the two groups were similar. After adjusting for multiple covariates, the adjusted odds ratios (OR) for participants in hypocalcemia group was 10.01 (95% CI 3.35–34.82), compared with that in normocalcemia group ( p < .001). Conclusion In patients undergoing heart valve surgery, preoperative blood concentrations of calcium are associated with postoperative blood loss. Hypocalcemia before operation may increase the risk of postoperative bleeding. When patients with valvular heart disease present with hypocalcemia before surgery, prompt intervention may lead to better control of postoperative bleeding.

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“…In the brain, PP2B is known as calcineurin and is a Ca 2+ /calmodulin-dependent protein phosphatase. The holoenzyme is a heterodimer made up of an 18-kDa regulatory subunit (B-subunit) and a 60-kDa catalytic subunit (A-subunit) [72]. The calmodulin-binding domain and the autoinhibitory domain in the catalytic subunit's C-terminal region often hide the catalytic domain and maintain the enzyme's inactive state [73].…”

Section: Protein Phosphatase 2b (Pp2b)mentioning

confidence: 99%

Molecular Role of Protein Phosphatases in Alzheimer’s and Other Neurodegenerative Diseases

Hassan,

Yasir,

Shahzadi

et al. 2024

Biomedicines

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Alzheimer’s disease (AD) is distinguished by the gradual loss of cognitive function, which is associated with neuronal loss and death. Accumulating evidence supports that protein phosphatases (PPs; PP1, PP2A, PP2B, PP4, PP5, PP6, and PP7) are directly linked with amyloid beta (Aβ) as well as the formation of the neurofibrillary tangles (NFTs) causing AD. Published data reported lower PP1 and PP2A activity in both gray and white matters in AD brains than in the controls, which clearly shows that dysfunctional phosphatases play a significant role in AD. Moreover, PP2A is also a major causing factor of AD through the deregulation of the tau protein. Here, we review recent advances on the role of protein phosphatases in the pathology of AD and other neurodegenerative diseases. A better understanding of this problem may lead to the development of phosphatase-targeted therapies for neurodegenerative disorders in the near future.

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Role of calcineurin biosignaling in cell secretion and the possible regulatory mechanisms

Cited by 8 publications

References 52 publications

Stress responses in an Arctic microalga (Pelagophyceae) following sudden salinity change revealed by gene expression analysis

Stress responses in an Arctic microalga (Pelagophyceae) following sudden salinity change revealed by gene expression analysis

The association between preoperative blood calcium and postoperative blood loss in patients undergoing heart valve replacement surgery

Molecular Role of Protein Phosphatases in Alzheimer’s and Other Neurodegenerative Diseases

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