Role of Cardiac and Vascular Amplifiers in the Maintenance of Hypertension and the Effect of Reversal of Cardiovascular Hypertrophy

Pi, Korner; Jennings, Garry; Esler, M.; Broughton, Archer

doi:10.1111/j.1440-1681.1985.tb02632.x

Cited by 7 publications

(3 citation statements)

References 16 publications

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“…Hypertrophy of the vasculature was not measured in these animals but a few indirect indices argue against significant vessel wall thickening. It is known that the amplifying effects of vessel hypertrophy aid in the maintenance of an elevated blood pressure in hypertensives (Korner et al 1985;Adams et al 1990). Therefore, it would be expected that dogs might develop a chronic hypertension in the presence of significant vessel hypertrophy.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Hypertensive Episodes and Cardiac Hypertrophy on the Canine Cardiac Baroreflex

Kingwell

Krause

Julius

1994

Clin Exp Pharma Physio

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1. Left ventricular (LV) hypertrophy has been implicated in the reduction of baroreflex sensitivity present in hypertension. The aim of the current study was to investigate the mean arterial pressure-heart rate reflex (MAP-HR) in a model which induced left ventricular hypertrophy but no sustained blood pressure elevation. 2. Five mongrel dogs were exposed to transient blood pressure elevation of between 20 and 30 mmHg, through hindlimb compression using a pneumatic pressure suit, for 7 h per day, 6 days per week for 6 weeks. Resting blood pressure was not altered by the 6 week hindlimb compression intervention. 3. Echocardiographically determined LV mass (mean +/- s.e.m.) was 116.0 +/- 7.4 g prior to hindlimb compression (baseline) and elevated to 125.4 +/- 8.1 g (P = 0.003) after 6 weeks of compression. A reduction in the early (E) to late (A) transmitral diastolic flow ratio (E/A) from 1.80 +/- 0.06 at baseline to 1.54 +/- 0.09 (P = 0.037) after the 6 week intervention suggested that cardiac compliance was reduced. 4. The maximum gain of the MAP-HR reflex, studied using the 'steady-state' drug technique, when blood pressure was normal, showed a trend for reduction from 3.85 +/- 0.43 beats/min per mmHg at baseline to 3.10 +/- 0.45 beats/min per mmHg (P = 0.067) after 6 weeks of compression. This gain reduction became significant after beta-adrenoceptor blockade with propranolol (3.13 +/- 0.55 vs 2.32 +/- 0.25 beats/min per mmHg; P = 0.039). Covariant analysis showed a significant inverse correlation between LV mass and maximum gain (r = 0.96; P < 0.001) during the 6 week compression period.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 99%

The Effect of Hypertensive Episodes and Cardiac Hypertrophy on the Canine Cardiac Baroreflex

Kingwell

Krause

Julius

1994

Clin Exp Pharma Physio

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“…Long-term antihypertensive treatment can diminish the vascular structural changes" and this can slow down the rate of redevelopment of hypertension after withdrawal of the therapy. 21 Further, cardiac hypertrophy has been shown to be a major risk factor for sudden death." Therefore, it is important to examine the influence of various antihypertensive agents on the heart.…”

Section: Reversal Of Cardiovascular Hypertrophymentioning

confidence: 99%

Initial therapy of primary hypertension

Jennings

Sudhir²

1990

Medical Journal of Australia

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“…The major fall in BP may occur within 1 day but when the drug is ceased, it may take days, weeks or months before the BP returns to its previ ous level. This is interpreted to mean that control of elevated BP has allowed regression of the cardiac and vascular amplifiers to take place [18] and when BP has been well controlled for a considerable time, this slow rise became evident. In this study the dietary intervention had progressed for 3 months.…”

Section: " 8 5 " 1------------1 ------------1 -------------------1 --mentioning

confidence: 99%

Comparative Studies of Reduced Sodium and High Potassium Diet in Hypertension

Morgan

Nowson²

1987

Nephron

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A decrease in sodium intake or an increase in potassium intake reduces blood pressure (BP) in people with essential hypertension. Additional potassium prevents, in sodium-sensitive people and rats, the rise in BP caused by extra sodium chloride. In people with a diastolic BP between 90 and 100 mm Hg, dietary reduction of sodium to 80 mmol/day and dietary increase of potassium to 90 mmol/day caused a fall in BP of 5.1/4.2 and 3.6/3.1 mm Hg, respectively, greater than was observed in the control group. There was a negative interaction between the two diets when used together with a BP change of 4.0/3.6 mm Hg. The fall in BP with sodium restriction was not reversed by the addition of sodium chloride and a similar fall in BP was not achieved with potassium chloride. It is possible that the response is due to some other factor. A strong correlation existed between the change in urine Na :K and the fall in BP. This study indicates that a reduced sodium or an increased potassium diet will reduce BP and should be considered for the initial management of essential hypertension.

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Role of Cardiac and Vascular Amplifiers in the Maintenance of Hypertension and the Effect of Reversal of Cardiovascular Hypertrophy

Cited by 7 publications

References 16 publications

The Effect of Hypertensive Episodes and Cardiac Hypertrophy on the Canine Cardiac Baroreflex

The Effect of Hypertensive Episodes and Cardiac Hypertrophy on the Canine Cardiac Baroreflex

Initial therapy of primary hypertension

Comparative Studies of Reduced Sodium and High Potassium Diet in Hypertension

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