2004
DOI: 10.1002/jcp.20021
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Role of caspases in the regulation of apoptotic pancreatic islet beta‐cells death

Abstract: The homeostatic control of beta-cell mass in normal and pathological conditions is based on the balance of proliferation, differentiation, and death of the insulinsecreting cells. A considerable body of evidence, accumulated during the last decade, has emphasized the significance of the disregulation of the mechnanisms regulating the apoptosis of beta-cells in the sequence of events that lead to the development of diabetes. The identification of agents capable of interfering with this process needs to be based… Show more

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Cited by 96 publications
(87 citation statements)
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References 250 publications
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“…The final steps resulting in apoptosis involve both endoplasmic reticulum stress (37) and mitochondrial disruption (38). Glucose toxicity has also been associated with intrinsic pathways involving Bad and Bid that converge on mitochondrial disruption (39). Reductions in cytochrome c release and caspase 9 activation, key components of apoptosis associated with mitochondrial disruption, are probable consequences of the regulation of Bax expression by GIP.…”
Section: Discussionmentioning
confidence: 99%
“…The final steps resulting in apoptosis involve both endoplasmic reticulum stress (37) and mitochondrial disruption (38). Glucose toxicity has also been associated with intrinsic pathways involving Bad and Bid that converge on mitochondrial disruption (39). Reductions in cytochrome c release and caspase 9 activation, key components of apoptosis associated with mitochondrial disruption, are probable consequences of the regulation of Bax expression by GIP.…”
Section: Discussionmentioning
confidence: 99%
“…The loss of islet beta cells through apoptosis (programmed cell death) is a cause of type 1 and type 2 diabetes (for review see [23]). Members of the TGF-β superfamily, particularly activins, have been implicated in regulating islet beta cell apoptosis as well as proliferation, differentiation and other functions [24][25][26].…”
Section: Introductionmentioning
confidence: 99%
“…Sel T sitotoksik akan menghasilkan perforin, granzim, dan Fas ligand untuk memicu sinyal apoptosis. 9 Malondialdehid merupakan marker stres oksidatif akibat peroksidasi lipid. Malondialdehid berada dalam berbagai bentuk bergantung pada pH.…”
Section: Pendahuluanunclassified