Role of CD25 expression on prognosis of acute myeloid leukemia: A literature review and meta-analysis

Abstract

The gene expression for interleukin-2 receptor subunit alpha (CD25/IL2RA) is frequently altered in adults with acute myeloid leukemia (AML). Increasing evidence indicates that the elevated expression of CD25 may be correlated with poor survival for AML patients. Thus, we performed this meta-analysis to further evaluate the prognostic value of elevated CD25 in AML. Eligible studies were gathered by searching on PubMed, Web of Science, and Embase. Using the R language 3.6.0 software, Pooled hazard ratios (HRs) with their corresponding 95% confidence intervals (CIs) of overall survival (OS) and disease-free survival (DFS)/relapse-free survival (RFS)/event-free survival (EFS) for total and subgroup analyses were calculated to investigate the association of elevated CD25 and outcomes of AML patients. Ten studies with a total of 1640 participants were enrolled in this meta-analysis. Pooled HRs suggested that overexpression of CD25 predicted poor outcomes on both OS (HR = 2.27, 95%CI 1.95-2.64) and DFS/RFS/EFS (HR = 1.77, 95%CI 1.44-2.17) in overall population. Subgroup analyses stratified by ethnicity, AML subtype, cutoff value, statistical methodologies and detection method draw similar results. Our meta-analysis indicates that elevated CD25 expression is a poor prognostic factor for AML patients. Considering limited number of samples, further relevant studies are warranted.

High IL2RA/CD25 expression is a prognostic stem cell biomarker for pediatric acute myeloid leukemia without a core‐binding factor

“…Of the 103 patients, 28 (27%) showed high CD25 expression. CD25‐high AML prevalence in children is similar to that in adult patients 11 . The characteristics of CD25‐high and CD25‐low patients are listed in Table 1.…”

“…CD25high AML prevalence in children is similar to that in adult patients. 11 The characteristics of CD25-high and CD25-low patients are listed in Table 1. CD25 expression positively correlated with FLT3-ITD as reported previously, 4,12 as well as with NUP98::NSD1 and high…”

CD123 as a Biomarker in Hematolymphoid Malignancies: Principles of Detection and Targeted Therapies

“…Cytokines and the cytokine receptors system have been shown to play an important role in leukemogenesis as well as in the biological and clinical behavior of various myeloid neoplasms. In AML, the levels of CD123, GM-CSF, interleukin-2 receptor alpha chain (IL-2Rα; CD25), common gamma-chain cytokine (γc), c-kit, and granulocyte colony-stimulating factor receptor (G-CSFR) were widely expressed with a range of more than 10,000 sites/cell, and their expression patterns correlated with morphologic subtypes [ 36 , 37 ].…”