Role of CD73 and extracellular adenosine in disease

Robson, Simon C.

doi:10.1007/s11302-011-9265-4

Cited by 7 publications

(4 citation statements)

References 37 publications

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“…CD73, together with ADA are the primary enzymes involved in the generation and metabolism of adenosine. St. Hilaire et al (2011) and Robson (2011) reported the existence of non-sense or missense mutations in the CD73 gene (resulting in a non-functional protein) in sibling members with lower extremity arterial calcification in three families. The authors hypothesize that reduced adenosine levels increases ALP activity and consequently increased degradation of pyrophosphate to inorganic phosphate which in turn affects arterial calcification.…”

Section: Adenosine Metabolism and Bone Physiologymentioning

confidence: 99%

An emerging role for adenosine and its receptors in bone homeostasis

Ham¹,

Evans²

2012

Front. Endocrin.

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Bone is continually being remodeled and defects in the processes involved lead to bone diseases. Many regulatory factors are known to influence remodeling but other mechanisms, hitherto unknown, may also be involved. Importantly, our understanding of these currently unknown mechanisms may lead to important new therapies for bone disease. It is accepted that purinergic signaling is involved in bone, and our knowledge of this area has increased significantly over the last 15 years, although most of the published work has studied the role of ATP and other signaling molecules via the P2 family of purinergic receptors. During the last few years, however, there has been increased interest within the bone field in the role of P1 receptors where adenosine is the primary signaling molecule. This review will bring together the current information available in relation to this expanding area of research.

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Section: Adenosine Metabolism and Bone Physiologymentioning

confidence: 99%

An emerging role for adenosine and its receptors in bone homeostasis

Ham¹,

Evans²

2012

Front. Endocrin.

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“…The authors hypothesize that the calcification seen in individuals with CD73 mutations is due to decreased inhibition of TNAP secondary to reduced levels of adenosine. However, as pointed out by some commentators , the expression of ectonucleotidases on fibroblasts is different to that on VSMCs; moreover, CD73 KO mice do not seem to exhibit ectopic calcification. Therefore, the exact mechanism underlying these intriguing observations remains a subject for further investigation.…”

Section: Roles Played By Other Ecto‐nucleotidasesmentioning

confidence: 95%

ATP and arterial calcification

Fish¹,

Klootwijk²,

Tam

et al. 2013

Eur J Clin Investigation

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“…All of the above findings verified the significant function of eukaryotic CD73 in human health and disease. Moreover, they showed that targeting tumor-derived CD73 may be a powerful adjunct therapeutic procedure to combat tumor development either individually or in combination with other procedures [90,91].…”

Section: Cd73 Structure/functionsmentioning

confidence: 99%

An overview of current therapeutic strategies for glioblastoma and the role of CD73 as an alternative curative approach

Arab

Hasannejad

2021

Clin Transl Oncol

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Glioblastoma multiforme (GBM) is a complicated and heterogeneous brain tumor with short-term survival outcomes. Commercial therapies are not practical due to cell infiltration capacity, high proliferative rate, and blood-brain barrier. In this context, recognition of the molecular mechanism of tumor progression might help the development of new cancer therapeutics. Recently, more evidence has supported CD73 and downstream adenosine A2A/A2B receptor signaling playing a crucial role in glioblastoma pathogenesis; therefore, targeting CD73 in murine tumor models can reduce tumor development.CD73 is an ecto-enzyme inducing tumor metastasis, angiogenesis, and immune escape via the production of extracellular adenosine in the tumor microenvironment. In this review, we provided information about clinical characteristics as well as the therapeutic management of glioblastoma. Then, we focused on newly available experimental evidence distinguishing between the essential role of CD73 on this tumor growth and a new method for the treatment of GBM patients.

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Role of CD73 and extracellular adenosine in disease

Cited by 7 publications

References 37 publications

An emerging role for adenosine and its receptors in bone homeostasis

An emerging role for adenosine and its receptors in bone homeostasis

ATP and arterial calcification

An overview of current therapeutic strategies for glioblastoma and the role of CD73 as an alternative curative approach

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