Role of cell cycle regulators in adipose tissue and whole body energy homeostasis

Abstract

In the course of the last decades, metabolism research has demonstrated that adipose tissue is not an inactive tissue. Rather, adipocytes are key actors of whole body energy homeostasis. Numerous novel regulators of adipose tissue differentiation and function have been identified. With the constant increase of obesity and associated disorders, the interest in adipose tissue function alterations in the XXIst century has become of paramount importance. Recent data suggest that adipocyte differentiation, adipose tissue browning and mitochondrial function, lipogenesis and lipolysis are strongly modulated by the cell division machinery. This review will focus on the function of cell cycle regulators in adipocyte differentiation, adipose tissue function and whole body energy homeostasis; with particular attention in mouse studies.

p27 regulates the autophagy-lysosomal pathway via the control of Ragulator and mTOR activity in amino acid deprived cells

“…Recent evidence indicate that other components of the cell cycle machinery are also involved in metabolic control at the transcriptional level. The CDK4/Rb/E2F1 pathway drives the expression of a number of genes involved in metabolism, notably in mitochondrial function and lipogenesis, possibly allowing metabolic adaptation to the proliferative state of specific tissues 90, 91 .…”

Association between visceral adiposity and DDX11 as a predictor of aggressiveness of small clear-cell renal-cell carcinoma: a prospective clinical trial

“…The underlying mechanism that links visceral adiposity to the upregulation of DDX11 expression is unknown. DDX11, a DNA-dependent ATPase and helicase, plays an important role in the cohesion of chromosome arms and centromeres [32]. The depletion of DDX11 results in mitotic failure because the replicated chromosomes fail to segregate after prometaphase [32].…”

“…DDX11, a DNA-dependent ATPase and helicase, plays an important role in the cohesion of chromosome arms and centromeres [32]. The depletion of DDX11 results in mitotic failure because the replicated chromosomes fail to segregate after prometaphase [32]. DDX11 expression may be associated with the G1-S phase of the cell-cycle and the pathways involved in DNA replication [32].…”

“…The depletion of DDX11 results in mitotic failure because the replicated chromosomes fail to segregate after prometaphase [32]. DDX11 expression may be associated with the G1-S phase of the cell-cycle and the pathways involved in DNA replication [32]. Recent studies suggest that adipocyte differentiation, lipogenesis, and lipolysis are strongly modulated by cell-cycle regulators, which control the checkpoints for cell duplication [33].…”

Relação de polimorfismos nos genes da perilipina 1, visfatina, resistina e grelina com a resposta a um programa de orientação nutricional para a redução de peso corporal

“…Sabemos que o organismo humano apresenta tecido adiposo branco e marron, os quais desempenham constituição e funcionalidades diferentes no metabolismo e desenvolvimento da obesidade. Dados recentes sugerem que a diferenciação de adipócitos, entre os tipos de tecido adiposo, assim como a função mitocondrial, a lipogênese e a lipólise são fortemente moduladas por reguladores do ciclo celular (Lopez-Mejia et al, 2017).…”