Role of central opioid on the antinociceptive effect of sulfated polysaccharide from the red seaweed Solieria filiformis in induced temporomandibular joint pain

Araújo, Ianna Wivianne Fernandes de; Chaves, Hellíada Vasconcelos; Pachêco, José Mário; Val, Danielle Rocha do; Vieira, Lorena Vasconcelos; Santos, Rodrigo da Silva; Freitas, Raquel; Rivanor, Renata Line da Conceição; Monteiro, Valdécio Silvano; Clemente-Napimoga, Juliana Trindade; Bezerra, Mirna Marques; Benevídes, Norma Maria Barros

doi:10.1016/j.intimp.2017.01.005

Cited by 27 publications

(12 citation statements)

References 68 publications

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“…Gc-FI is dependent on NO and CO, whereas Cr only relies on the HO-1 pathway and its functionality not influenced by the integrity of NO (Ribeiro et al, 2020;Coura et al, 2017). Last, Gc-FI also depends on the activation of opioid receptors to exert its antinociceptive effect, which was also confirmed in SPs from S. filiformis (Araújo et al, 2017). Rather than being selective, SPs from S. filiformis interact with all the three opioid receptors in the TMJ hypernociception of rats, such as morphine, and thus may serve as a relatively safer alternative for opioids.…”

Section: Sps From Marine Algae-derived Productsmentioning

confidence: 59%

Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective

Cai

et al. 2021

Front. Pharmacol.

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Temporomandibular joint disorders (TMD) are a common health condition caused by the structural or functional disorders of masticatory muscles and the temporomandibular joint (TMJ). Abnormal mandibular movement in TMD patients may cause pain, chronic inflammation, and other discomfort, which could be relieved by a variety of drugs through various delivery systems. In this study, we summarized commonly used therapeutic agents in the management of TMD as well as novel bioactive molecules in preclinical stage and clinical trials. The emerging therapy strategies such as novel intra-TMJ delivery systems and implants based on tissue engineering are also discussed. This comprehensive review will strengthen our understanding of pharmacological approaches for TMD therapy.

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Section: Sps From Marine Algae-derived Productsmentioning

confidence: 59%

Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective

Cai

et al. 2021

Front. Pharmacol.

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“…Seven studies investigated the effect of natural products on animals injected with formalin in the TMJ. The treatment with sulfated polysaccharides originated from the seaweed Solieria filiformis , 19 with polysulfated fraction of the seaweed Gracilaria cornea , 11 lectins isolated from Artocarpus incisa , 10 C. cupressoides 20 and A. esculentus , 21 (−)-α-bisabolol (topical or systemic) 22 or eucalyptol reduced formalin-induced nociception in the TMJ. 23 Four studies investigated NP in zymosan-induced nociception.…”

Section: Resultsmentioning

confidence: 99%

“…The treatment with the sulfated polysaccharide fraction from C. cupressoides caused antinociception followed by reduced leukocyte infiltration in zymosan-injected TMJ, 17 whereas the polysulfated fraction of G. cornea in the formalin model was described as dependent on opioid receptors and nitric oxide pathways as well as HO-1 activation and formation of IL-10 in the trigeminal ganglion and subnucleus caudalis, 11 which corroborated previous results about this fraction down-regulated the production of proinflammatory mediators associated with the involvement of the HO-1 pathway 36 The antinociceptive action of sulfated polysaccharides from S. filiformis also involved opioid receptors with increased release of β-endorphin in the subnucleus caudalis, while in TMJ the plasma protein extravasation and TNF-α and IL-1β concentrations were lower. 19 …”

Section: Discussionmentioning

confidence: 99%

The effect of natural products in animal models of temporomandibular disorders

et al. 2020

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The effect of natural products in animal models of temporomandibular disorders Treatment of temporomandibular disorders (TMD) is a challenge for health care professionals. Therefore, new approaches have been investigated, such as the use of natural products. Objective: This systematic review aims to summarize the natural products used in treatment of experimental models of TMD. Methodology: A systematic search was performed in the databases Medline, Web of Science, Scopus, Embase, SciELO, LILACS, and Scholar Google databases in January 2020, dating from their inception. Pre-clinical studies with natural products for intervention in experimental TMD were included. Two reviewers independently selected the studies, extracted the data, and evaluated the risk of bias. Results: 17 records were selected, and 17 different natural products were found, including three lectins, three plants or algae extracts, three sulfated polysaccharides, three cocoa preparations, and five isolated compounds. Concerning the risk of bias, most studies lacked on randomization and blinding. Nociception induced by phlogistic agents was evaluated in most articles, and in five studies it was associated with analysis of inflammatory parameters. In order to investigate the mechanism of action of the natural products used, eight studies evaluated expression of neural or glial molecular markers. Conclusions: 16 of 17 natural products found in this review presented positive results, showing their potential for treatment of TMD. However, the lack of methodological clarity can influence these results.

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“…Furthermore, cellulose microfibril from Gelidium amansii lead to JNK1/2 and p38 inhibition [119], and cellulose nanocrystals from the same seaweed revealed COX-2 and ERK1/2 inhibition [120]. Sulphated polysaccharide outcomes include reduced neutrophil (Agardhiella ramosossima [121]) and leukocyte (Gracilaria birdae [122], Gracilaria caudata [123], Gracilaria cornea [124], Hypnea musciformis [125]) migration/infiltration; reduced paw oedema (Agardhiella ramosossima [121], Gelidium crinale [126], Gracilaria birdiae [122], Gracilaria caudata [123], Gracilaria cornea [124] Hypnea musciformis [125]); NO and TLR4 inhibition (Gelidium pacificum [127]); IL-1β and TNF-α inhibition (Gracilaria caudata [123], Solieria filiformis [128]); and COX-2 and 5-LOX inhibition (Gracilaria opuntia, Kappaphycus alvarezii [129]). These studies included red seaweed compounds which were able to inhibit ILs and TNF-α, which are important triggers of the inflammatory pathways involved in AV, among others.…”

Section: Anti-inflammatory Extracts and Compounds From Red Macroalgaementioning

confidence: 99%

Red Seaweed-Derived Compounds as a Potential New Approach for Acne Vulgaris Care

Januário

Félix

et al. 2021

Pharmaceutics

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Acne vulgaris (AV) is a chronic skin disease of the pilosebaceous unit affecting both adolescents and adults. Its pathophysiology includes processes of inflammation, increased keratinization, sebum production, hormonal dysregulation, and bacterial Cutibacterium acnes proliferation. Common AV has been treated with antibiotics since the 1960s, but strain resistance has emerged and is of paramount concern. Macroalgae are known producers of substances with bioactive properties, including anti-viral, antibacterial, antioxidant, and anti-inflammatory properties, among several others. In particular, red algae are rich in bioactive compounds such as polysaccharides, phenolic compounds, lipids, sterols, alkaloids, and terpenoids, conferring them antioxidant, antimicrobial, and anti-inflammatory activities, among others. Thus, the exploration of compounds from marine resources can be an appealing approach to discover new treatment options against AV. The aim of this work is to provide an overview of the current knowledge of the potentialities of red macroalgae in the treatment of AV by reviewing the main therapeutic targets of this disease, and then the existence of compounds or extracts with bioactive properties against them.

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Role of central opioid on the antinociceptive effect of sulfated polysaccharide from the red seaweed Solieria filiformis in induced temporomandibular joint pain

Cited by 27 publications

References 68 publications

Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective

Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective

The effect of natural products in animal models of temporomandibular disorders

Red Seaweed-Derived Compounds as a Potential New Approach for Acne Vulgaris Care

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