Role of cholecystokinin in dietary fat-promoted azaserine-induced pancreatic carcinogenesis in rats

Abstract

Summary The role of cholecystokinin in dietary fat-promoted pancreatic carcinogenesis was investigated in azaserine-treated rats, using lorglumide, a highly specific cholecystokinin-receptor antagonist. The animals were killed 8 months after the start of treatment.Cholecystokinin, but not dietary unsaturated fat, increased pancreatic weight. Rats treated with cholecystokinin developed more acidophilic atypical acinar cell nodules, adenomas and adenocarcinomas than control animals. Rats maintained on the high-fat diet developed significantly more adenomas and adenocarcinomas than controls given a diet low in unsaturated fat. Lorglumide largely inhibited the enhancing effect of cholecystokinin, but not of dietary fat, on pancreatic carcinogenesis indicating that it is unlikely that the promoting effect of dietary unsaturated fat on pancreatic carcinogenesis is mediated via cholecystokinin.

Fat, Protein, and Meat Consumption and Renal Cell Cancer Risk: A Pooled Analysis of 13 Prospective Studies

“…Dietary fat has been hypothesized to increase the risk for cancers of the colon, pancreas, and prostate by increasing the release of bile acids ( 42 ), cholecystokinin ( 43 ), and prostaglandins ( 44 ). However, specifi c mechanisms have not been identifi ed for renal cell cancer.…”

Epidemiology and diagnosis of the pancreatic cancer: Epidemiología y diagnóstico

“…Several epidemiological studies (5,6) have also shown that nearly 15% of patients have a history of diabetes mellitus, which seemingly is a higherthan-expected figure. However, the onset of clinical diabetes preceded the diagnosis of pancreatic cancer by not more than 3 months in more than half of patients with diabetes and pancreatic cancer (18).…”

“…Han sido implicados así mismo diversos factores dietéticos (6). Al menos un estudio demostró, una correlación real entre el consumo de café y el cáncer de páncreas.…”

“…A number of dietary factors are also involved (6). At least one study demonstrated an actual correlation between coffee ingestion and pancreatic cancer.…”

Roles of gastrointestinal hormones in pancreatic cancer

“…Several lines of evidence have shown that CCK promoted the development of azaserine‐induced acidophilic atypical acinar cell nodules in rat pancreas. When combined with azaserine, the long‐term administration of CCK, high‐fat or trypsin‐inhibitor feeding, and pancreaticobiliary diversion all enhanced the development or shortened the latency to the preneoplastic acinar lesions induced by azaserine. These effects can be blocked by specific CCK‐A receptor antagonists,36,37,39 suggesting that CCK‐A receptors mediate this pancreatic carcinogenesis enhanced by CCK.…”