Role of cholinergic, opioidergic and GABAergic neurotransmission of the dorsal hippocampus in the modulation of nociception in guinea pigs

Mendes, Lys Angela Favaroni; Menescal-de-Oliveira, Leda

doi:10.1016/j.lfs.2008.09.006

Cited by 46 publications

(26 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alterations in nociceptive responses have been shown to reflect changes in the hippocampal cholinergic or GABAergic transmission (19). The colocalization of opioid receptors with gamma-aminobutyric acid receptors within the hippocampus structures (31) and the observed opioid inhibition of the GABAergic interneurons resulting in the excitation of the pyramidal cells (32,33) suggest the opioidergic transmission within the hippocampus would also influence the nociceptive response, which is supported by the observed antinociceptive responses on direct injection of morphine into the hippocampus structures (34).…”

Section: Discussionmentioning

confidence: 99%

“…Microinjection of thioperamide, a histamine H 3 receptor antagonist, into the DG increased histamine-induced antinociception of the formalin-induced pain, whereas both H 1 and H 2 receptor antagonists, chlorpheniramine and ranitidine, blocked the histamine effect (18). Direct injection of carbachol, morphine, or bicuculline into the dorsal hippocampus promoted antinociception (19). These studies and others provide supportive evidence for the role of the hippocampus in pain sensation.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Neurod1 Modulates Opioid Antinociceptive Tolerance via Two Distinct Mechanisms

Zhou

et al. 2014

Biological Psychiatry

View full text Add to dashboard Cite

Background The activity of neurogenic differentiation 1 (Neurod1) decreases after morphine administration, which leads to impairments of the stability of dendritic spines in primary hippocampal neurons, adult neurogenesis in mouse hippocampi, and drug-associated contextual memory. The current study examined whether Neurod1 could affect the development of opioid tolerance. Methods Lentivirus encoding Neurod1, microRNA-190 (miR-190), or short hairpin RNA against Neurod1 was injected into mouse hippocampi separately or combined (more than eight mice for each treatment) to modulate Neurod1 activity. The antinociceptive median effective dose values of morphine and fentanyl were determined with tail-flick assay and used to calculate development of tolerance. Contextual learning and memory were assayed using the Morris water maze. Results Decrease in NeuroD1 activity increased the initial antinociceptive median effective dose values of both morphine and fentanyl, which was reversed by restoring NeuroD1 activity. In contrast, decrease in NeuroD1 activity inhibited development of tolerance in a time-dependent manner, paralleling its effects on the acquisition and extinction of contextual memory. In addition, only development of tolerance, but not antinociceptive median effective dose values, was modulated by the expression of miR-190 and Neurod1 driven by Nestin promoter. Conclusions Neurod1 regulates the developments of opioid tolerance via a time-dependent pathway through contextual learning and a short-response pathway through antinociception.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Neurod1 Modulates Opioid Antinociceptive Tolerance via Two Distinct Mechanisms

Zhou

et al. 2014

Biological Psychiatry

View full text Add to dashboard Cite

show abstract

“…Application of an artery clip to the base of a toe elicits an audible squeak response that can be suppressed by analgesic agents [30]. Electric shocks have also been associated with vocalisation [31, 32]. However, all reports of anti-nociceptive testing appears to have been restricted to acute withdrawal methods, which have limited relevance to post-surgical pain control [33].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Using Behavioural Changes to Assess Post-Operative Pain in the Guinea Pig (Cavia porcellus)

2016

View full text Add to dashboard Cite

To manage pain effectively in people and animals, it is essential to recognise when pain is present and to assess its intensity. Currently there is very little information regarding the signs of post-surgical pain or its management in guinea pigs. Studies from other rodent species indicate that behaviour-based scoring systems can be used successfully to detect pain and evaluate analgesic efficacy. This preliminary study aimed to establish whether behaviour-based scoring systems could be developed to assess post-surgical pain in guinea pigs. This prospective, randomised, placebo-controlled study used 16 guinea pigs, and evaluated changes in behaviour following either anaesthesia alone or anaesthesia and orchiectomy. Behaviour was assessed using a combination of manual and automated scoring of remotely obtained video footage. A small number of behaviours were identified that appeared to have high specificity for pain caused by orchiectomy. However, the behaviours were displayed infrequently. The most common was a change in posture from standing to recumbency, sometimes with one hind leg extended either to the side or behind the body. A composite behaviour score incorporating these abnormal behaviours differentiated between the effects of surgery and anaesthesia alone (p<0.0001), and between animals that received analgesia post-operatively compared to an untreated group (p<0.0001). Although behavioural changes occurred in these guinea pigs after orchiectomy, the changes were relatively subtle and the individual specific pain-related behaviours occurred infrequently. However, it may prove possible to develop a behaviour-based scoring system for routine use in this species using a combination of pain-related behaviours.

show abstract

“…Several reports support a role for acetylcholine (ACh) in the inhibition and modulation of the transmission of nociceptive information [38, 39]. It has been demonstrated that the cholinergic system is involved in antinociceptive mechanisms, by (1) the activation of the GABAergic system [40]; (2) Muscarinic receptors (mAChR) mediation on spinal and (3) supraspinal sites [41, 42]; (4) inhibition enhancement of nicotinic receptors in the spinal dorsal horn [43]; (5) peripheral mAChR [44] or by interaction with the opioid system; however, this correlation is still not well elucidated.…”

Section: Discussionmentioning

confidence: 99%

Libidibia ferreaMature Seeds Promote Antinociceptive Effect by Peripheral and Central Pathway: Possible Involvement of Opioid and Cholinergic Receptors

Sawada

Monteiro

Rabelo

et al. 2014

BioMed Research International

View full text Add to dashboard Cite

Libidibia ferrea (LF) is a medicinal plant that holds many pharmacological properties. We evaluated the antinociceptive effect in the LF aqueous seed extract and Lipidic Portion of Libidibia ferrea (LPLF), partially elucidating their mechanisms. Histochemical tests and Gas chromatography of the LPLF were performed to characterize its fatty acids. Acetic acid-induced abdominal constriction, formalin-induced pain, and hot-plate test in mice were employed in the study. In all experiments, aqueous extract or LPLF was administered systemically at the doses of 1, 5, and 10 mg/kg. LF aqueous seed extract and LPLF demonstrated a dose-dependent antinociceptive effect in all tests indicating both peripheral anti-inflammatory and central analgesia properties. Also, the use of atropine (5 mg/kg), naloxone (5 mg/kg) in the abdominal writhing test was able to reverse the antinociceptive effect of the LPLF, indicating that at least one of LF lipids components is responsible for the dose related antinociceptive action in chemical and thermal models of nociception in mice. Together, the present results suggested that Libidibia ferrea induced antinociceptive activity is possibly related to its ability to inhibit opioid, cholinergic receptors, and cyclooxygenase-2 pathway, since its main component, linoleic acid, has been demonstrated to produce such effect in previous studies.

show abstract

Role of cholinergic, opioidergic and GABAergic neurotransmission of the dorsal hippocampus in the modulation of nociception in guinea pigs

Cited by 46 publications

References 48 publications

Neurod1 Modulates Opioid Antinociceptive Tolerance via Two Distinct Mechanisms

Neurod1 Modulates Opioid Antinociceptive Tolerance via Two Distinct Mechanisms

Evaluation of Using Behavioural Changes to Assess Post-Operative Pain in the Guinea Pig (Cavia porcellus)

Libidibia ferreaMature Seeds Promote Antinociceptive Effect by Peripheral and Central Pathway: Possible Involvement of Opioid and Cholinergic Receptors

Contact Info

Product

Resources

About