Role of Chromatography for Monitoring of Breast Cancer Biomarkers

Ali, Imran; ALOthman, Zeid A.; Saleem, Kishwar; Hussain, Afzal; Hussain, İqbal

doi:10.2174/2210309011101010089

Cited by 5 publications

(3 citation statements)

References 63 publications

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“…Most of these are rare and often do not increase the risk of BC as much as do mutations in the BRCA genes. Detection of BC at an early stage is extremely important to reduce the burden of disease because earlier detection leads to better patient outcomes, as metastatic states are avoided 6 7 . Currently, there is no single screening test that is totally reliable, and a number of tests can be combined to help detect early stage BC.…”

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confidence: 99%

Volatile metabolomic signature of human breast cancer cell lines

Silva

Perestrelo

Tomás

2017

Sci Rep

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Breast cancer (BC) remains the most prevalent oncologic pathology in women, causing huge psychological, economic and social impacts on our society. Currently, the available diagnostic tools have limited sensitivity and specificity. Metabolome analysis has emerged as a powerful tool for obtaining information about the biological processes that occur in organisms, and is a useful platform for discovering new biomarkers or make disease diagnosis using different biofluids. Volatile organic compounds (VOCs) from the headspace of cultured BC cells and normal human mammary epithelial cells, were collected by headspace solid-phase microextraction (HS-SPME) and analyzed by gas chromatography combined with mass spectrometry (GC–MS), thus defining a volatile metabolomic signature. 2-Pentanone, 2-heptanone, 3-methyl-3-buten-1-ol, ethyl acetate, ethyl propanoate and 2-methyl butanoate were detected only in cultured BC cell lines. Multivariate statistical methods were used to verify the volatomic differences between BC cell lines and normal cells in order to find a set of specific VOCs that could be associated with BC, providing comprehensive insight into VOCs as potential cancer biomarkers. The establishment of the volatile fingerprint of BC cell lines presents a powerful approach to find endogenous VOCs that could be used to improve the BC diagnostic tools and explore the associated metabolomic pathways.

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confidence: 99%

Volatile metabolomic signature of human breast cancer cell lines

Silva

Perestrelo

Tomás

2017

Sci Rep

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“…This type of assistant cancer therapy has been long-term noticed and draw attentions from all scientific disciplines. These advancements include new drug development, optimizing chemotherapeutic schedules, drug combinative strategies, pharmacogenetics [34], individualized antimetastatic therapy [35][36][37] and pharmaceutical changed [38][39][40][41][42]. Growing bodies of Fib-related assistant cancer therapy studies and applications may help the high quality of clinical cancer trials.…”

Section: Future Perspectivesmentioning

confidence: 99%

Plasma Fibrinogen Concentrations in Patients with Solid Tumors and Therapeutic Improvements by Combining Anticoagulants or Fibrinolytical Agents

Tr¹,

B²

2015

Adv Pharmacoepidemiol Drug Saf

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Many of patient's deaths with solid tumors are caused by altered pathogenesis coagulation cascade components and processes in clinics. Therapeutic actions for inhibiting cancer coagulation complications in clinics are indispensable part of modern cancer therapies. This editorial discusses the relationship between plasma/solid tumor fibrinogen levels and mechanisms of action by anticoagulants and fibrinolytic agents. Revisit old theory with latest hypothetic and therapeutic options. Many updating clinical information between fibrinogen malformation and its specific therapy are highlighted herein.

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“…Biological monitoring of natural ecosystems can be performed by the use of biomarkers from bioindicator species to quantify the degree of exposure to contaminants [ 5 ]. Biomarkers are very important in different fields of biological science [ 6 , 7 ] and different biochemical and genetic methods are used to find the best biomarkers [ 8 , 6 ]. A pollution responsive biomarker is a quantitative measure of changes in molecular or cellular components, processes, structures and functions related to exposure to environmental chemicals [ 9 ].…”

Section: Introductionmentioning

confidence: 99%