Role of chromosome instability in long term effect of manned-space missions

Ducray, Caroline; Sabatier, Laure

doi:10.1016/s0273-1177(98)00082-9

Cited by 12 publications

(9 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the (2001) shows that a steep increase in chromosomal aberrations and the effect on plant growth during the first and second generations were observed for root tip cells from Pisum sativum exposed to 0.4 Gy of 60 Co-c rays, which proved the existence of this phenomenon in plants. Since the genomic instability may be induced by space radiation, especially by the HZE particles, and may be related to canceration in long-term effects of space flight, it has been studied widely in recently years (Ducray and Sabatier, 1998). The genomic changes and the phenotypic variations in the progenies of I-B15, the rice seeds whose embryos received Mg particle hits, might be used as an example for this kind of mechanism.…”

Section: Discussionmentioning

confidence: 99%

Genomic polymorphism in consecutive generation rice plants from seeds on board a spaceship and their relationship with space HZE particles

et al. 2007

View full text Add to dashboard Cite

Dry rice seeds (Oryza sativa, subspecies indica) were sandwiched between nuclear track detectors, aboard the Chinese spaceship Shenzhou-3 for seven days. The seeds were recovered and the genomic polymorphism in 201 plants developed from these seeds was studied using random amplified polymorphism DNA analysis. When compared with plants from ground-based control seeds, the genomic polymorphic bands were amplified in 30.2% of the plants from the seeds exposed in space. The results for sequencing and SNP analyses of the polymorphic bands verified the single nucleotide variations in these plants. Genomic polymorphisms in the consecutive generations of individual plants of the seeds from space were also discovered. Seven seeds receiving hits of HZE (high atomic number and high energy) particles from space were selected for further analyses and variable genomic polymorphisms were detected in all plants that developed from these seeds. Among them, the embryos of three seeds were hit at least once, and mutants with significant changes in agronomic traits were only found in later generations of these seeds. This result implies that the HZE particles of space are effective in inducing the changes of plant genome of inherited phenotypes.

show abstract

Section: Discussionmentioning

confidence: 99%

Genomic polymorphism in consecutive generation rice plants from seeds on board a spaceship and their relationship with space HZE particles

et al. 2007

View full text Add to dashboard Cite

show abstract

“…For example, the consequences of persistent chromosomal rearrangements found in white blood cells from astronauts or cosmonauts after their return to earth are unknown (George et al 2010) as are the possible role in inducing genomic instability many cell generations after high-LET radiation exposure (Ducray and Sabatier 1998; NA/NRC 2012). The identification of individual genetic susceptibility might require screening of sensitive individuals for certain kinds of radiation work (NCRP 2010).…”

Section: Future Research Neededmentioning

confidence: 99%

Lauriston S. Taylor Lecture on Radiation Protection and Measurements

Blakely¹

2012

Health Physics

View full text Add to dashboard Cite

The scientific basis for the physical and biological effectiveness of particle radiations has emerged from many decades of meticulous basic research. A diverse array of biologically relevant consequences at the molecular, cellular, tissue, and organism level have been reported, but what are the key processes and mechanisms that make particle radiation so effective, and what competing processes define dose dependences? Recent studies have shown that individual genotypes control radiation-regulated genes and pathways in response to radiations of varying ionization density. The fact that densely ionizing radiations can affect different gene families than sparsely ionizing radiations, and that the effects are dose- and time-dependent has opened up new areas of future research. The complex microenvironment of the stroma, and the significant contributions of the immune response have added to our understanding of tissue-specific differences across the linear energy transfer (LET) spectrum. The importance of targeted vs. nontargeted effects remain a thorny, but elusive and important contributor to chronic low dose radiation effects of variable LET that still needs further research. The induction of cancer is also LET-dependent, suggesting different mechanisms of action across the gradient of ionization density. The focus of this 35th Lauriston S. Taylor Lecture is to chronicle the step-by-step acquisition of experimental clues that have refined our understanding of what makes particle radiation so effective, with emphasis on the example of radiation effects on the crystalline lens of the human eye.

show abstract

“…Chromosome instability (CIN) is a great concern for manned-space flight because of the space environment-induced damages to human chromosomes observed in the lymphocytes of Astronauts [1]. Structural and numerical chromosome instabilities are the two aspects of CIN commonly observed in solid tumors [2], [3].…”

Section: Introductionmentioning

confidence: 99%

Experimental Study on Effect of Simulated Microgravity on Structural Chromosome Instability of Human Peripheral Blood Lymphocytes

Wei

Liu

et al. 2014

PLoS ONE

View full text Add to dashboard Cite

Experimental study was made by keeping human peripheral blood lymphocytes under simulated microgravity in a Rotary Cell Culture System bioreactor to investigate the changes that occur in the number of chromosomes, the expression rate of chromosome fragile site, and the expressions of DNA replication- and repair-related genes. Experimental results indicate simulated microgravity has no effect on the numerical chromosome instability of human peripheral blood lymphocytes, but it enhances the structural chromosome instability of human peripheral blood lymphocytes through the inhibition of DNA replication and the reduction of DNA repair. So, the mechanism of chromosome fragile site induced by simulated microgravity can be explained using the changes that occur in the chromosome structure of human peripheral blood lymphocytes, the DNA replication and repair under the effect of simulated microgravity.

show abstract

Role of chromosome instability in long term effect of manned-space missions

Cited by 12 publications

References 18 publications

Genomic polymorphism in consecutive generation rice plants from seeds on board a spaceship and their relationship with space HZE particles

Genomic polymorphism in consecutive generation rice plants from seeds on board a spaceship and their relationship with space HZE particles

Lauriston S. Taylor Lecture on Radiation Protection and Measurements

Experimental Study on Effect of Simulated Microgravity on Structural Chromosome Instability of Human Peripheral Blood Lymphocytes

Contact Info

Product

Resources

About