Role of circulatory congestion in the cardiorespiratory failure of obesity

Kaltman, Alfred J.; Goldring, Roberta M.

doi:10.1016/0002-9343(76)90499-x

Cited by 145 publications

(76 citation statements)

References 26 publications

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“…At any given level of activity, the cardiac workload is greater for obese subjects [33,34] who have a higher cardiac output and a lower total peripheral resistance than do lean individuals. The increased cardiac output is attributable mostly to increased stroke volume because heart rate increases little if at all [35,36]. Hence, the obese group in our series displayed significantly higher left ventricular mass, cardiac output, left atrium diameter, diastolic and systolic volumes and diameters ( Table 2), in agreement with previous reports [10,13,23,[31][32][33].…”

Section: Discussionsupporting

confidence: 92%

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The influence of obesity duration on left ventricular mass, volume and function: A pilot study

Ybarra¹,

Romeo²,

Fernández³

et al. 2012

Health

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Introduction: Despite the bulk of evidence between obesity and cardiovascular complications, the effect of the duration of obesity (DOO) on cardiac function has so far received limited attention. The aim of the study is to study the relationship between a new, American Heart Association (AHA) and World Health Organization (WHO)-adapted formula for reporting DOO with echocardiographic findings and co-morbidities in a large cohort of individuals whose BMI ranged from normal (<25 Kg·m

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Section: Discussionsupporting

confidence: 92%

“…The correlation between DOO and cardiac output in our series ( Table 2) have not been reported using the same methodology but fall in agreement with the pathophysiology and hemodynamics of obesity per se [32][33][34][35].…”

Section: Discussionsupporting

confidence: 85%

The influence of obesity duration on left ventricular mass, volume and function: A pilot study

Ybarra¹,

Romeo²,

Fernández³

et al. 2012

Health

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“…Interestingly, some obese patients with symptoms of systemic and pulmonary congestion have normal systolic function; however, diastolic function is often abnormal (32), and 35% to 40% of patients with congestive heart failure may have diastolic dysfunction only (33). Furthermore, diastolic dysfunction and pulmonary hypertension can be worse after exercise.…”

Section: Discussionmentioning

confidence: 99%

CD1d-Associated Expression of NF-κB and Cardiac Dysfunction in Diabetic and Obese Mice

Madonna

Shelat

et al. 2013

Int J Immunopathol Pharmacol

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The first two authors contributed equally to this studyIn patients with obesity and diabetes mellitus, abnormal production of inflammatory factors may result in cardiovascular dysfunction. In the current study, we tested the impact of CDld-mediated innate immune responses on the expression and activation of NFKB in the hearts of adipose diabetic (db/db) mice. Splenocytes from adult db/db and CDld-knockout mice of both genders and their wildtype, C57BL/6 and Balb/C counterparts were examined for tumor necrosis factor (TNF)-a and TNF-a receptor type 1. The percentage of natural killer T (NKT) cells in CD3+ T cells was compared with that in nondiabetic control mice. Despite the absence of inflammatory infiltrates, the hearts of db/db mice showed alterations in TNF-a receptor-I and NFKB activity, including increased expression of both the NFKB p52 and p65 subunits. In the hearts of CDld-knockout mice, p52 expression was reduced, while p65 expression remained largely unchanged. On echocardiography, the ratio of E to A transmitral flow velocities (an indicator of diastolic function) was significantly decreased in db/db mice after they swam for 30 minutes. These results provide evidence for CDld-mediated NFKB activation and diastolic dysfunction in the hearts of db/db mice. Therefore, CDld-associated abnormalities of innate immune responses and TNF-a production in splenic tissue may contribute to NFKB activation and cardiac dysfunction in type 2 diabetes.

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“…The physiological adaptations to obesity are especially important when exercise programs or medications are introduced. It must be considered that obesity causes persistent disproportionate elevations in cardiac filling pressures during exercise [147][148][149]. Patients must start slowly, in order to reverse some of the complications that have already developed; these patients have a baseline condition of rarefraction, therefore a limit in functional hyperemia, and increased risk of tissue hypoxia/ischemia, which may cause further muscle damage [58].…”

Section: Interventions/management Of Obesitymentioning

confidence: 99%

Obesity and vascular dysfunction

et al. 2008

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One of the most profound challenges facing public health and public health policy in Western society is the increased incidence and prevalence of both overweight and obesity. While this condition can have significant consequences for patient mortality and quality of life, it can be further exacerbated as overweight/obesity can be a powerful stimulus for the development of additional risk factors for a negative cardiovascular outcome, including increased insulin resistance, dyslipidemia and hypertension. This manuscript will present the effects of systemic obesity on broad issues of vascular function in both afflicted human populations and in the most relevant animal models. Among the topics that will be covered are alterations to vascular reactivity (both dilator and constrictor responses), adaptations in microvascular network and vessel wall structure, and alterations to the patterns of tissue/organ perfusion as a result of the progression of the obese condition. Additionally, special attention will be paid to the contribution of chronic inflammation as a contributor to alterations in vascular function, as well as the role of perivascular adipose tissue in terms of impacting vessel behavior. When taken together, it is clearly apparent that the development of the obese condition can have profound, and frequently difficult to predict, impacts on integrated vascular function. Much of this complexity appears to have its basis in the extent to which other co-morbidities associated with obesity (e.g., insulin resistance) are present and exert contributing effects.

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Role of circulatory congestion in the cardiorespiratory failure of obesity

Cited by 145 publications

References 26 publications

The influence of obesity duration on left ventricular mass, volume and function: A pilot study

The influence of obesity duration on left ventricular mass, volume and function: A pilot study

CD1d-Associated Expression of NF-κB and Cardiac Dysfunction in Diabetic and Obese Mice

Obesity and vascular dysfunction

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