Role of class II histocompatibility antigens in Staphylococcus aureus protein A-lnduced activation of human T lymphocytes

Romagnani, Sergio; Almerigogna, Fabio; Biagiotti, R; Alessi, Anna; Damiani, G; Ricci, M; Ferrone, Soldano

doi:10.1016/0008-8749(85)90168-6

Cited by 6 publications

(1 citation statement)

References 49 publications

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“…The quality and quantity of antibody responses to a given antigen are under genetic control of the H-2 locus (38). SpA-activated B cells induce proliferation of human T cells in an MHC class II-dependent manner (39). To determine whether a specific H-2 type favors V H 3 antibody expansion, multiple inbred mouse strains with well-defined MHC haplotypes were treated with nSpA, and blood samples were analyzed for V H 3 + IgM and IgG responses ( Fig.…”

Section: Igbd Repeat Variation Affects Staphylococcal Binding To Ig Hmentioning

confidence: 99%

Peptidoglycan-linked protein A promotes T cell-dependent antibody expansion duringStaphylococcus aureusinfection

Kim

Falugi

Missiakas

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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A hallmark of Staphylococcus aureus disease in humans is persistent infections without development of protective immune responses. Infected patients generate V H 3 plasmablast expansions and increased V H 3 idiotype Ig; however, the mechanisms for staphylococcal modification of immune responses are not known. We report here that S. aureus-infected mice generate V H 3 antibody expansions via a mechanism requiring MHC-restricted antigen presentation to CD4 + T cells and staphylococcal protein A (SpA), a cell wall-anchored surface molecule that binds Fcγ and V H 3 variant heavy chains of Ig. V H 3 expansion occurred with peptidoglycan-linked SpA from the bacterial envelope but not with recombinant SpA, and optimally required five tandem repeats of its Ig-binding domains. Signaling via receptor-interacting serine/threonine protein kinase 2 (RIPK2) was essential for implementing peptidoglycan-linked SpA superantigen activity. V H 3 clan IgG from S. aureus-infected or SpA-treated animals was not pathogen-specific, suggesting that SpA cross-linking of V H 3 idiotype B-cell receptors and activation via attached peptidoglycan are the determinants of staphylococcal escape from adaptive immune responses.

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Section: Igbd Repeat Variation Affects Staphylococcal Binding To Ig Hmentioning

confidence: 99%

Peptidoglycan-linked protein A promotes T cell-dependent antibody expansion duringStaphylococcus aureusinfection

Kim

Falugi

Missiakas

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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Role of HLA class I and class II antigens in activation and differentiation of B cells

Biagiotti¹,

Almerigogna²,

Alessi³

et al. 1987

Cellular Immunology

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Mitogenic activity of staphylococcal protein A is due to contaminating staphylococcal enterotoxins

Schrezenmeier

Fleischer

1987

Journal of Immunological Methods

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Role of class II histocompatibility antigens in Staphylococcus aureus protein A-lnduced activation of human T lymphocytes

Cited by 6 publications

References 49 publications

Peptidoglycan-linked protein A promotes T cell-dependent antibody expansion duringStaphylococcus aureusinfection

Peptidoglycan-linked protein A promotes T cell-dependent antibody expansion duringStaphylococcus aureusinfection

Role of HLA class I and class II antigens in activation and differentiation of B cells

Mitogenic activity of staphylococcal protein A is due to contaminating staphylococcal enterotoxins

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