Role of color Doppler indices in predicting disease-free survival of breast cancer patients during neoadjuvant chemotherapy

Singh, Gurpreet; Kumar, Pratik; Parshad, Rajinder; Seith, Ashu; Thulkar, Sanjay; Hosten, Norbert

doi:10.1016/j.ejrad.2009.12.027

Cited by 26 publications

(19 citation statements)

References 19 publications

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“…Since color and spectral Doppler ultrasound allows semiquantitative assessment of tumor vascularity, measurements of peak systolic velocity, end-diastolic velocity, resistivity index and pulsatility index have shown the potential to serve as a functional tool for monitoring tumor response to chemotherapy [27]–[29]. However, the high degree of subjectivity as well as its lack of reproducibility makes it impossible to gain wide acceptance in clinical practice [30].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Early Tumor Response to Cytotoxic Chemotherapy with Dynamic Contrast-Enhanced Ultrasound in Human Breast Cancer Xenografts

et al. 2013

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There is a strong need to assess early tumor response to chemotherapy in order to avoid adverse effects from unnecessary chemotherapy and allow early transition to second-line therapy. This study was to quantify tumor perfusion changes with dynamic contrast-enhanced ultrasound (CEUS) in the evaluation of early tumor response to cytotoxic chemotherapy. Sixty nude mice bearing with MCF-7 breast cancer were administrated with either adriamycin or sterile saline. CEUS was performed on days 0, 2, 4 and 6 of the treatment, in which time-signal intensity (SI) curves were obtained from the intratumoral and depth-matched liver parenchyma. Four perfusion parameters including peak enhancement (PE), area under the curve of wash-in (WiAUC), wash-in rate (WiR) and wash-in perfusion index (WiPI) were calculated from perfusion curves and normalized with respect to perfusion of adjacent liver parenchyma. Histopathological analysis was conducted to evaluate tumor perfusion, tumor cell density, microvascular density (MVD) and proliferating cell density. Significant decreases of tumor normalized perfusion parameters (i.e., nPE, nWiAUC, nWiR and nWiPI) were noticed between adriamycin-treated and control groups (P<0.01) 2 days after therapy. There were significant differences of tumor volumes between control and treated groups on day 6 (P<0.001) while there were no significant differences in tumor volume on days 0, 2 and 4 (P>0.05). Significant decreases of tumor perfusion, tumor cell density, MVD and proliferating cell density were seen in adrianycin-treated group 2 days after therapy when compared to control group (P<0.001). Dynamic CEUS for quantification of tumor perfusion could be used for early detection of cancer response to cytotoxic chemotherapy prior to notable tumor shrinkage.

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Section: Discussionmentioning

confidence: 99%

Assessment of Early Tumor Response to Cytotoxic Chemotherapy with Dynamic Contrast-Enhanced Ultrasound in Human Breast Cancer Xenografts

et al. 2013

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“…Ultrasound is a readily available technique for monitoring therapeutic effects and has been frequently used in clinical practice. Color Doppler ultrasound can be used for objective semiquantitative assessment of tumor vascularity, and measurement of peak systolic velocity, end-diastolic velocity, resistivity index, and pulsatility index has been found to have potential as a functional tool for monitoring tumor response to chemotherapy [19][20][21]. However, measurement with color Doppler ultrasound has not gained wide acceptance because of the high degree of subjectivity and lack of reproducibility [22].…”

Section: Discussionmentioning

confidence: 99%

Contrast-Enhanced Gray-Scale Ultrasound for Quantitative Evaluation of Tumor Response to Chemotherapy: Preliminary Results With a Mouse Hepatoma Model

Zhou

Cao

Zheng

et al. 2011

American Journal of Roentgenology

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“…Since color and spectral Doppler ultrasound allows semiquantitative assessment of tumor vascularity, measurements of peak systolic velocity, end-diastolic velocity, resistivity index and pulsatility index have shown the potential to serve as a functional tool for monitoring tumor response to chemotherapy [27][28][29]. However, the high degree of subjectivity as well as its lack of reproducibility makes it impossible to gain wide acceptance in clinical practice [30].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Early Tumor Response to Cytotoxic Chemotherapy With Dynamic Contrast-Enhanced Ultrasound in Human Breast Cancer Xenografts

Zhou

Wang

Zheng

et al. 2013

Ultrasound in Medicine & Biology

View full text Add to dashboard Cite

There is a strong need to assess early tumor response to chemotherapy in order to avoid adverse effects from unnecessary chemotherapy and allow early transition to second-line therapy. This study was to quantify tumor perfusion changes with dynamic contrast-enhanced ultrasound (CEUS) in the evaluation of early tumor response to cytotoxic chemotherapy. Sixty nude mice bearing with MCF-7 breast cancer were administrated with either adriamycin or sterile saline. CEUS was performed on days 0, 2, 4 and 6 of the treatment, in which time-signal intensity (SI) curves were obtained from the intratumoral and depth-matched liver parenchyma. Four perfusion parameters including peak enhancement (PE), area under the curve of wash-in (WiAUC), wash-in rate (WiR) and wash-in perfusion index (WiPI) were calculated from perfusion curves and normalized with respect to perfusion of adjacent liver parenchyma. Histopathological analysis was conducted to evaluate tumor perfusion, tumor cell density, microvascular density (MVD) and proliferating cell density. Significant decreases of tumor normalized perfusion parameters (i.e., nPE, nWiAUC, nWiR and nWiPI) were noticed between adriamycintreated and control groups (P,0.01) 2 days after therapy. There were significant differences of tumor volumes between control and treated groups on day 6 (P,0.001) while there were no significant differences in tumor volume on days 0, 2 and 4 (P.0.05). Significant decreases of tumor perfusion, tumor cell density, MVD and proliferating cell density were seen in adrianycin-treated group 2 days after therapy when compared to control group (P,0.001). Dynamic CEUS for quantification of tumor perfusion could be used for early detection of cancer response to cytotoxic chemotherapy prior to notable tumor shrinkage.

show abstract

Role of color Doppler indices in predicting disease-free survival of breast cancer patients during neoadjuvant chemotherapy

Cited by 26 publications

References 19 publications

Assessment of Early Tumor Response to Cytotoxic Chemotherapy with Dynamic Contrast-Enhanced Ultrasound in Human Breast Cancer Xenografts

Assessment of Early Tumor Response to Cytotoxic Chemotherapy with Dynamic Contrast-Enhanced Ultrasound in Human Breast Cancer Xenografts

Contrast-Enhanced Gray-Scale Ultrasound for Quantitative Evaluation of Tumor Response to Chemotherapy: Preliminary Results With a Mouse Hepatoma Model

Assessment of Early Tumor Response to Cytotoxic Chemotherapy With Dynamic Contrast-Enhanced Ultrasound in Human Breast Cancer Xenografts

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