Role of Combination Drug Therapy for Management of Hypertension With Increasing Age

Abstract

Objective: In South Asia, hypertension is the third highest factor contributing in public health burden of disease and major risk factor for coronary artery disease especially in women and old age people. The study was aimed to determine the role of gender and age (20–80 years) on severity of hypertension to design an effective schedule for management of hypertension. Methods: The levels of serum cholesterol, triglycerides (TG), high-density lipoprotein (HDL), low-density lipoproteins (LDL), and blood pressure (BP) of 240 hypertensive patients were monitored. Cholesterol, TG, and HDL levels were detected using ERBA Reagent kit of Transasia Bio-medicals LTD by CHOD-PAP, glycerol phosphate oxidase trinder End point, and polyvinyl sulfonic and polyethyleneglycol-methyl ether based methods, respectively. Results: The BP and levels of serum cholesterol, TG and LDL were increased in both the genders after 40 years of age. However, the rise in levels of these parameters was more in females in comparison to males. A hypertension management schedule involving (BP)/Cholesterol lowering drugs and lifestyle changes for period of 60 days showed that combination drug therapy was more effective than monotherapies of same drugs used at higher dosages. Conclusion: Hypertensive patients strictly followed the prescribed healthy food and exercise schedule showed improvement in their BP and lipid profile even with limited drug intervention.

A comparative study of efficacy and safety in stage I hypertensive patients visiting the cardiac OPD at a tertiary care hospital

“…Other drugs in the angiotensin II receptor blocker (ARB) family, which also includes olmesartan, include telmisartan, candesartan, losartan, valsartan, as well as irbesartan [5]. ARBs specifically bind to the angiotensin receptor 1 (AT1), blocking the binding of the protein angiotensin II.…”

A Comparative Study of Efficacy and Safety of Azilsartan 40mg and Telmisartan 40mg in Stage I Hypertensive Patients Attending Cardiac Opd at Tertiary Care Hospital

“…Blockade of the renin-angiotensin system with ACE inhibitors has provided effective treatment of these conditions; however, some of the adverse effects of ACE inhibitors appear to be unrelated to angiotensin II blockade. For example, cough and angioedema are due to other effects of ACE inhibition, such as the degradation of bradykinins and prostaglandins [7]. In general, ARBs are well tolerated.…”

To Evaluate the Safety and Efficacy of Amlodipine and Chlorthalidone in Combination With Telmisartan in Hypertensive Patients Attending Tertiary Care Centre, Telangana

“…A hypertension management schedule involving (BP)/Cholesterollowering drugs and lifestyle changes for a period of 60 d showed that combination drug therapy was more effective than immunotherapies of the same drugs used at higher dosages [9]. Various types of fixeddose combinations have recently been developed and used, revealing improved patient adherence to their convenient regimen [6].…”